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OPENSEQ.org
HOFN - Putative DNA utilization protein HofN
UniProt: P64634 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12924
Length: 179 (169)
Sequences: 377
Seq/Len: 2.23
HOFN
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
70_P 73_L 2.546 1.00
3_P 10_W 2.308 1.00
109_H 133_A 1.933 0.99
61_L 64_S 1.758 0.98
20_R 24_L 1.739 0.97
29_P 103_A 1.662 0.96
56_Q 61_L 1.646 0.96
17_A 25_M 1.567 0.94
29_P 32_L 1.56 0.94
16_T 20_R 1.554 0.94
2_N 144_D 1.545 0.94
68_T 81_Q 1.495 0.92
50_I 53_V 1.477 0.92
123_E 166_E 1.385 0.88
16_T 19_L 1.365 0.87
5_I 8_L 1.362 0.87
84_Q 97_S 1.35 0.86
109_H 155_T 1.342 0.86
134_L 158_D 1.315 0.84
50_I 54_L 1.315 0.84
22_W 50_I 1.302 0.83
138_E 167_Y 1.286 0.82
40_L 147_F 1.282 0.82
85_R 90_Q 1.27 0.81
138_E 152_R 1.27 0.81
26_F 77_Q 1.266 0.81
46_A 110_A 1.262 0.81
27_V 67_I 1.249 0.80
7_F 126_G 1.239 0.79
54_L 130_S 1.225 0.78
77_Q 80_E 1.22 0.77
61_L 71_R 1.216 0.77
128_T 156_Q 1.213 0.77
66_Q 69_K 1.211 0.77
86_Q 90_Q 1.21 0.77
96_Q 134_L 1.208 0.77
24_L 77_Q 1.202 0.76
7_F 92_T 1.175 0.74
61_L 72_L 1.173 0.73
124_I 168_Q 1.172 0.73
53_V 109_H 1.168 0.73
83_S 95_W 1.161 0.72
101_A 104_A 1.157 0.72
82_R 99_L 1.154 0.72
63_R 66_Q 1.147 0.71
50_I 72_L 1.143 0.71
69_K 119_Q 1.134 0.70
96_Q 117_W 1.126 0.69
28_A 115_I 1.123 0.69
116_S 120_G 1.112 0.68
88_Q 138_E 1.107 0.67
134_L 153_G 1.106 0.67
31_L 106_L 1.094 0.66
22_W 75_Q 1.092 0.66
90_Q 135_N 1.09 0.65
43_T 51_D 1.089 0.65
109_H 150_N 1.079 0.64
36_I 148_H 1.078 0.64
35_G 59_Q 1.077 0.64
60_Q 141_L 1.073 0.64
37_T 103_A 1.072 0.64
10_W 15_R 1.068 0.63
50_I 109_H 1.067 0.63
22_W 26_F 1.066 0.63
84_Q 134_L 1.064 0.63
85_R 109_H 1.064 0.63
72_L 152_R 1.063 0.63
38_L 65_L 1.057 0.62
124_I 169_L 1.055 0.62
20_R 118_Q 1.055 0.62
152_R 156_Q 1.055 0.62
131_I 152_R 1.055 0.62
106_L 167_Y 1.051 0.61
66_Q 92_T 1.049 0.61
10_W 90_Q 1.044 0.60
35_G 122_L 1.038 0.60
22_W 99_L 1.034 0.59
83_S 86_Q 1.031 0.59
20_R 86_Q 1.03 0.59
96_Q 152_R 1.026 0.59
13_Q 44_G 1.025 0.58
104_A 139_T 1.025 0.58
72_L 138_E 1.024 0.58
49_R 124_I 1.021 0.58
122_L 147_F 1.02 0.58
99_L 153_G 1.02 0.58
33_A 145_A 1.015 0.57
35_G 118_Q 1.014 0.57
98_A 103_A 1.013 0.57
102_L 112_L 1.012 0.57
102_L 143_Q 1.009 0.57
84_Q 128_T 1.001 0.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4bhqA20.737499.90.493Contact Map0.164
2rjzA20.67690.20.886Contact Map0.219
2w7vA20.469382.90.898Contact Map0.207
3hd7B20.245813.20.94Contact Map0.533
2m8rA10.245813.20.94Contact Map0.392
3ra3A20.156413.10.94Contact Map0.584
2j5uA20.804511.30.942Contact Map0.424
3zjzA40.4869.70.943Contact Map0.502
3ra3B20.15649.40.944Contact Map0.538
1a93B10.18999.10.944Contact Map0.45
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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