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OPENSEQ.org

YHEO - Uncharacterized protein YheO
UniProt: P64624 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12899
Length: 240 (215)
Sequences: 446
Seq/Len: 2.07

YHEO
Paralog alert: 0.18 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
36_V 51_L 2.837 1.00
39_L 49_I 2.571 1.00
43_I 47_C 2.529 1.00
47_C 132_M 1.989 0.99
218_I 223_V 1.925 0.99
24_T 120_R 1.915 0.99
139_S 143_S 1.912 0.99
220_K 225_L 1.876 0.98
61_A 76_S 1.842 0.98
69_H 110_M 1.84 0.98
36_V 65_A 1.777 0.97
37_D 65_A 1.719 0.97
38_G 115_I 1.692 0.96
73_K 76_S 1.671 0.96
218_I 222_T 1.649 0.96
36_V 63_R 1.644 0.95
79_T 83_L 1.644 0.95
40_A 63_R 1.603 0.95
212_V 223_V 1.586 0.94
22_D 26_F 1.562 0.94
162_S 165_D 1.559 0.93
36_V 82_A 1.523 0.92
182_R 189_K 1.499 0.92
118_R 124_V 1.495 0.91
79_T 157_V 1.478 0.91
60_S 78_I 1.444 0.89
99_C 118_R 1.423 0.88
190_N 226_Y 1.398 0.87
163_V 166_L 1.388 0.87
30_K 33_E 1.374 0.86
52_H 100_Y 1.371 0.86
206_K 209_I 1.345 0.84
39_L 43_I 1.342 0.84
57_L 60_S 1.313 0.82
50_V 217_N 1.301 0.82
39_L 47_C 1.296 0.81
32_Y 126_G 1.294 0.81
32_Y 117_I 1.294 0.81
216_L 227_I 1.293 0.81
43_I 104_A 1.282 0.80
213_A 223_V 1.273 0.80
193_I 216_L 1.272 0.80
38_G 225_L 1.27 0.79
198_Y 231_K 1.268 0.79
79_T 102_T 1.244 0.77
51_L 128_L 1.237 0.77
38_G 220_K 1.225 0.76
164_E 194_V 1.218 0.75
79_T 129_C 1.185 0.72
54_L 100_Y 1.184 0.72
86_L 168_T 1.184 0.72
60_S 80_D 1.184 0.72
185_S 190_N 1.179 0.72
62_I 125_I 1.178 0.72
204_D 226_Y 1.177 0.72
132_M 171_L 1.176 0.72
187_N 229_Q 1.174 0.71
29_L 112_S 1.168 0.71
182_R 187_N 1.157 0.70
35_V 63_R 1.15 0.69
82_A 127_L 1.148 0.69
102_T 112_S 1.148 0.69
198_Y 204_D 1.148 0.69
61_A 64_I 1.146 0.69
190_N 206_K 1.144 0.69
221_H 225_L 1.144 0.69
79_T 197_L 1.136 0.68
53_S 189_K 1.134 0.68
184_V 189_K 1.134 0.68
100_Y 114_T 1.132 0.67
69_H 133_N 1.124 0.67
108_V 133_N 1.124 0.67
116_A 124_V 1.121 0.66
96_V 113_L 1.117 0.66
119_N 123_R 1.114 0.66
113_L 163_V 1.108 0.65
183_N 217_N 1.103 0.65
37_D 41_M 1.102 0.64
52_H 83_L 1.096 0.64
52_H 131_N 1.093 0.63
51_L 63_R 1.092 0.63
75_G 112_S 1.092 0.63
56_D 124_V 1.086 0.63
194_V 222_T 1.082 0.62
108_V 135_D 1.057 0.60
202_I 212_V 1.056 0.60
51_L 146_V 1.054 0.59
52_H 129_C 1.054 0.59
172_E 176_E 1.052 0.59
54_L 201_G 1.047 0.59
135_D 207_D 1.045 0.58
185_S 193_I 1.044 0.58
63_R 74_I 1.044 0.58
209_I 215_R 1.043 0.58
36_V 128_L 1.042 0.58
172_E 215_R 1.032 0.57
40_A 71_G 1.032 0.57
206_K 226_Y 1.027 0.56
63_R 71_G 1.026 0.56
78_I 82_A 1.026 0.56
58_K 211_Q 1.026 0.56
80_D 159_F 1.025 0.56
40_A 43_I 1.021 0.56
72_R 129_C 1.018 0.55
187_N 225_L 1.018 0.55
129_C 206_K 1.016 0.55
129_C 157_V 1.014 0.55
49_I 215_R 1.013 0.55
80_D 129_C 1.009 0.54
125_I 160_A 1.009 0.54
34_A 198_Y 1.006 0.54
37_D 208_A 1.002 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2x48A30.229296.90.906Contact Map0.512
2elhA10.295896.50.912Contact Map0.312
4l5eA10.191796.40.912Contact Map0.374
1jkoC10.216796.10.915Contact Map0.434
2gloA10.2458960.916Contact Map0.387
1tc3C10.212595.70.917Contact Map0.56
4dyqA20.258395.60.918Contact Map0.187
2jn6A10.233395.60.918Contact Map0.369
3eyyA20.279295.40.92Contact Map0.447
2p5kA10.216795.20.92Contact Map0.584

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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