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OPENSEQ.org
GMHA - Phosphoheptose isomerase
UniProt: P63224 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13146
Length: 192 (188)
Sequences: 991
Seq/Len: 5.27
GMHA
Paralog alert: 0.56 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: DIAA GMHA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
50_C 115_L 4.308 1.00
109_G 139_M 3.679 1.00
131_I 152_M 3.277 1.00
143_T 156_A 2.996 1.00
40_S 114_V 2.87 1.00
129_K 132_A 2.409 1.00
62_F 179_I 2.381 1.00
33_A 142_I 2.331 1.00
40_S 45_G 2.241 1.00
131_I 141_V 2.182 1.00
13_A 17_L 1.999 1.00
49_S 62_F 1.959 1.00
73_N 95_F 1.932 1.00
48_L 105_V 1.916 1.00
123_N 151_K 1.851 1.00
76_G 107_A 1.785 1.00
34_A 185_L 1.766 1.00
135_R 157_D 1.726 1.00
66_L 186_I 1.711 1.00
49_S 116_L 1.675 1.00
67_T 87_H 1.656 0.99
45_G 112_G 1.641 0.99
49_S 179_I 1.568 0.99
88_I 100_I 1.544 0.99
146_G 171_I 1.527 0.99
36_L 158_I 1.508 0.99
33_A 158_I 1.503 0.99
119_S 152_M 1.495 0.99
50_C 127_V 1.485 0.99
144_L 178_V 1.475 0.98
60_M 85_V 1.473 0.98
117_G 131_I 1.415 0.98
14_A 17_L 1.406 0.98
68_G 91_V 1.37 0.97
87_H 91_V 1.358 0.97
132_A 155_T 1.319 0.96
170_R 173_E 1.306 0.96
160_I 178_V 1.298 0.96
41_F 47_V 1.291 0.96
58_D 65_E 1.287 0.96
99_D 129_K 1.286 0.96
14_A 18_A 1.273 0.95
50_C 117_G 1.267 0.95
92_G 97_F 1.247 0.94
76_G 106_E 1.24 0.94
61_H 65_E 1.231 0.94
48_L 80_I 1.227 0.94
117_G 127_V 1.211 0.93
133_A 136_E 1.207 0.93
162_V 174_I 1.204 0.93
93_N 121_S 1.2 0.93
148_D 161_R 1.188 0.92
98_N 125_A 1.179 0.92
145_T 161_R 1.178 0.92
36_L 140_K 1.169 0.92
133_A 137_K 1.166 0.91
97_F 100_I 1.161 0.91
37_L 47_V 1.161 0.91
15_E 19_N 1.159 0.91
52_N 126_N 1.158 0.91
65_E 172_Q 1.158 0.91
123_N 150_G 1.153 0.91
11_N 15_E 1.146 0.91
120_T 172_Q 1.144 0.90
117_G 141_V 1.144 0.90
132_A 136_E 1.137 0.90
96_G 99_D 1.137 0.90
106_E 133_A 1.135 0.90
47_V 116_L 1.132 0.90
64_E 68_G 1.125 0.89
45_G 110_R 1.123 0.89
30_I 178_V 1.123 0.89
145_T 159_E 1.122 0.89
65_E 120_T 1.114 0.89
58_D 120_T 1.097 0.88
80_I 108_V 1.092 0.87
82_I 104_Y 1.09 0.87
151_K 154_G 1.079 0.87
64_E 90_C 1.074 0.86
37_L 114_V 1.073 0.86
50_C 130_A 1.071 0.86
31_Q 35_V 1.069 0.86
49_S 63_A 1.069 0.86
61_H 93_N 1.055 0.85
67_T 107_A 1.049 0.84
13_A 174_I 1.043 0.84
143_T 159_E 1.032 0.83
68_G 103_R 1.03 0.83
46_K 78_P 1.027 0.83
60_M 83_S 1.026 0.83
68_G 90_C 1.013 0.82
153_A 161_R 1.006 0.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i2wA411000.45Contact Map0.733
2yvaA20.97921000.505Contact Map0.754
1tk9A40.96881000.507Contact Map0.873
2xblA40.99481000.509Contact Map0.822
1x92A20.98441000.511Contact Map0.783
3trjA40.98441000.515Contact Map0.864
4bb9A10.994899.90.653Contact Map0.511
3cvjA40.968899.90.662Contact Map0.765
3w0lB20.994899.90.663Contact Map0.572
1nriA10.984499.90.669Contact Map0.654
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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