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RL22 - 50S ribosomal protein L22
UniProt: P61175 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10882
Length: 110 (109)
Sequences: 1655
Seq/Len: 15.18

RL22
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
7_H 50_V 2.922 1.00
9_H 80_P 2.875 1.00
21_A 76_V 2.746 1.00
72_T 108_S 2.487 1.00
7_H 10_A 2.148 1.00
29_V 55_I 2.136 1.00
78_E 81_S 2.101 1.00
48_K 52_E 2.061 1.00
27_K 35_I 2.014 1.00
22_D 25_R 1.965 1.00
37_T 48_K 1.962 1.00
27_K 31_Q 1.943 1.00
85_I 93_A 1.936 1.00
21_A 74_I 1.863 1.00
21_A 47_V 1.859 1.00
24_I 51_L 1.759 1.00
78_E 99_R 1.696 1.00
10_A 46_L 1.658 1.00
12_S 17_V 1.644 1.00
54_A 107_V 1.638 1.00
68_D 109_D 1.601 1.00
42_K 46_L 1.568 1.00
86_M 94_D 1.522 1.00
51_L 71_V 1.503 1.00
88_R 94_D 1.498 1.00
51_L 105_V 1.494 1.00
85_I 95_R 1.407 0.99
51_L 55_I 1.406 0.99
81_S 99_R 1.404 0.99
59_E 66_I 1.399 0.99
61_N 64_A 1.39 0.99
87_P 94_D 1.358 0.99
87_P 93_A 1.358 0.99
28_K 31_Q 1.338 0.99
3_T 62_D 1.33 0.99
77_D 104_T 1.328 0.99
33_L 48_K 1.32 0.99
75_F 104_T 1.276 0.99
33_L 55_I 1.269 0.99
50_V 103_I 1.259 0.99
85_I 94_D 1.257 0.99
81_S 97_L 1.243 0.98
17_V 103_I 1.243 0.98
12_S 43_A 1.236 0.98
74_I 105_V 1.227 0.98
79_G 100_T 1.21 0.98
18_R 77_D 1.188 0.98
47_V 74_I 1.184 0.98
17_V 47_V 1.174 0.98
50_V 105_V 1.161 0.97
72_T 106_V 1.094 0.96
19_L 41_K 1.087 0.96
64_A 109_D 1.057 0.95
20_V 47_V 1.053 0.95
2_E 108_S 1.034 0.94
65_D 68_D 1.024 0.93
3_T 107_V 1.018 0.93
23_L 35_I 1.016 0.93
33_L 37_T 1.013 0.93
23_L 27_K 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4kixS111000.013Contact Map0.787
3j3wS111000.019Contact Map0.778
3bboU111000.032Contact Map0.514
2zjrP111000.051Contact Map0.74
1i4jA20.97271000.064Contact Map0.739
4a17Q10.99091000.077Contact Map0.685
1vq8R10.99091000.078Contact Map0.76
3zf7R10.99091000.086Contact Map0.669
3j21S10.99091000.087Contact Map0.677
2ftcM10.96361000.089Contact Map0.053

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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