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OPENSEQ.org

FIXA - Protein FixA
UniProt: P60566 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11562
Length: 256 (251)
Sequences: 1714
Seq/Len: 6.83

FIXA
Paralog alert: 0.38 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FIXA YDIQ YGCR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
73_R 84_L 4.094 1.00
156_T 171_S 3.813 1.00
131_G 179_A 3.583 1.00
56_Q 83_E 3.517 1.00
106_A 109_Q 3.017 1.00
44_A 47_Q 2.719 1.00
143_V 172_I 2.604 1.00
207_S 210_D 2.584 1.00
110_K 206_W 2.513 1.00
59_A 76_V 2.506 1.00
148_K 160_E 2.488 1.00
240_D 243_E 2.472 1.00
148_K 151_S 2.465 1.00
49_K 82_D 2.444 1.00
87_V 103_A 2.424 1.00
83_E 204_Q 2.318 1.00
77_L 84_L 2.191 1.00
44_A 185_N 2.169 1.00
157_L 172_I 2.095 1.00
105_A 109_Q 2.091 1.00
34_I 72_G 2.048 1.00
146_V 178_V 2.025 1.00
116_I 140_I 1.972 1.00
108_A 116_I 1.961 1.00
2_K 56_Q 1.951 1.00
101_A 137_I 1.912 1.00
118_C 134_V 1.847 1.00
121_G 126_Y 1.839 1.00
158_T 171_S 1.822 1.00
88_I 205_V 1.813 1.00
104_L 134_V 1.79 1.00
156_T 173_P 1.78 1.00
3_I 54_E 1.78 1.00
152_L 157_L 1.75 1.00
61_S 67_L 1.742 1.00
172_I 176_A 1.73 1.00
180_V 184_I 1.724 1.00
149_I 157_L 1.671 1.00
64_G 67_L 1.646 1.00
58_T 83_E 1.636 1.00
42_I 81_P 1.623 1.00
146_V 159_V 1.62 1.00
151_S 158_T 1.602 1.00
59_A 81_P 1.592 1.00
191_S 194_A 1.575 1.00
4_I 108_A 1.572 1.00
250_E 254_K 1.557 0.99
6_C 118_C 1.557 0.99
114_D 155_D 1.552 0.99
50_Q 188_Q 1.55 0.99
115_L 176_A 1.538 0.99
68_T 74_K 1.533 0.99
206_W 211_I 1.532 0.99
43_E 188_Q 1.531 0.99
110_K 204_Q 1.525 0.99
95_A 103_A 1.512 0.99
51_Q 151_S 1.507 0.99
239_G 243_E 1.496 0.99
35_S 38_D 1.476 0.99
110_K 211_I 1.464 0.99
158_T 169_T 1.442 0.99
58_T 85_I 1.44 0.99
68_T 205_V 1.428 0.99
161_R 168_E 1.405 0.99
65_K 88_I 1.404 0.99
39_L 79_R 1.398 0.99
57_V 81_P 1.383 0.99
208_A 215_A 1.382 0.99
67_L 86_V 1.378 0.98
157_L 174_L 1.369 0.98
61_S 86_V 1.342 0.98
60_L 107_A 1.325 0.98
19_N 22_D 1.31 0.98
241_G 245_I 1.294 0.97
141_P 176_A 1.272 0.97
26_D 29_K 1.267 0.97
2_K 58_T 1.26 0.97
160_E 169_T 1.259 0.97
44_A 148_K 1.247 0.97
40_N 185_N 1.228 0.96
153_T 158_T 1.214 0.96
153_T 156_T 1.214 0.96
143_V 170_L 1.194 0.95
105_A 138_L 1.176 0.95
195_I 201_K 1.163 0.94
155_D 173_P 1.158 0.94
37_Y 120_D 1.148 0.94
54_E 57_V 1.135 0.93
87_V 107_A 1.133 0.93
4_I 113_F 1.123 0.93
89_D 94_Q 1.121 0.93
140_I 177_V 1.117 0.93
108_A 113_F 1.116 0.93
34_I 76_V 1.109 0.92
193_K 197_G 1.094 0.92
58_T 111_A 1.091 0.92
46_C 194_A 1.087 0.91
160_E 167_T 1.087 0.91
103_A 107_A 1.087 0.91
135_G 142_A 1.078 0.91
107_A 206_W 1.076 0.91
46_C 79_R 1.076 0.91
96_L 218_A 1.071 0.91
85_I 206_W 1.07 0.91
106_A 110_K 1.067 0.90
105_A 134_V 1.063 0.90
108_A 134_V 1.058 0.90
77_L 201_K 1.057 0.90
59_A 73_R 1.028 0.88
157_L 178_V 1.028 0.88
7_Y 76_V 1.024 0.88
68_T 203_V 1.023 0.88
88_I 207_S 1.021 0.88
189_I 195_I 1.018 0.87
147_S 160_E 1.018 0.87
106_A 211_I 1.003 0.86
117_L 180_V 1.003 0.86
230_R 233_Q 1.002 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1o97C10.97661000.196Contact Map0.789
1efpB20.96481000.219Contact Map0.773
1efvB10.96481000.241Contact Map0.831
3ih5A40.77341000.627Contact Map0.65
1o97D10.82811000.64Contact Map0.532
1efvA10.820399.90.673Contact Map0.689
1efpA20.800899.90.678Contact Map0.61
3fetA40.640699.90.696Contact Map0.652
3dloA40.449288.30.935Contact Map0.728
3idfA20.4375880.935Contact Map0.563

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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