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OPENSEQ.org
PRP2 - Serine/threonine-protein phosphatase 2
UniProt: P55799 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13102
Length: 218 (206)
Sequences: 1627
Seq/Len: 7.90
PRP2
Paralog alert: 0.43 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: PRP1 PRP2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
58_E 61_D 6.579 1.00
204_T 213_S 4.269 1.00
27_Y 61_D 3.334 1.00
27_Y 31_Q 3.157 1.00
28_Q 58_E 3.043 1.00
48_S 66_L 2.868 1.00
23_I 62_V 2.635 1.00
33_R 214_F 2.526 1.00
75_K 80_A 2.49 1.00
37_L 214_F 2.49 1.00
39_F 44_D 2.39 1.00
27_Y 65_L 2.366 1.00
30_L 48_S 2.221 1.00
47_I 138_I 2.196 1.00
31_Q 65_L 2.148 1.00
19_V 138_I 2.139 1.00
72_T 127_I 2.062 1.00
182_Y 200_I 2.053 1.00
128_E 181_D 2.037 1.00
126_I 137_A 2.028 1.00
18_W 37_L 2.014 1.00
64_R 116_L 2.002 1.00
67_N 116_L 1.95 1.00
23_I 30_L 1.947 1.00
45_L 72_T 1.912 1.00
80_A 84_E 1.849 1.00
185_F 201_Y 1.819 1.00
200_I 215_Y 1.813 1.00
26_E 29_L 1.769 1.00
47_I 127_I 1.744 1.00
26_E 207_P 1.742 1.00
53_I 79_E 1.699 1.00
49_V 74_V 1.694 1.00
49_V 138_I 1.648 1.00
18_W 216_K 1.587 1.00
136_Y 217_I 1.578 1.00
20_V 214_F 1.566 1.00
30_L 65_L 1.531 1.00
185_F 199_Q 1.526 1.00
202_I 215_Y 1.504 1.00
87_E 121_H 1.495 0.99
64_R 67_N 1.494 0.99
48_S 71_F 1.488 0.99
52_N 62_V 1.486 0.99
63_L 120_F 1.455 0.99
64_R 107_D 1.443 0.99
30_L 62_V 1.399 0.99
184_I 202_I 1.399 0.99
19_V 184_I 1.396 0.99
34_L 65_L 1.368 0.99
189_M 201_Y 1.341 0.99
184_I 215_Y 1.335 0.99
64_R 109_E 1.311 0.98
114_I 118_L 1.305 0.98
136_Y 182_Y 1.294 0.98
21_G 213_S 1.29 0.98
81_M 97_S 1.288 0.98
60_L 64_R 1.272 0.98
21_G 204_T 1.258 0.98
184_I 200_I 1.255 0.98
75_K 153_E 1.248 0.98
54_D 98_G 1.223 0.97
137_A 183_F 1.22 0.97
189_M 207_P 1.213 0.97
54_D 78_H 1.202 0.97
16_H 216_K 1.193 0.97
48_S 73_S 1.187 0.96
16_H 44_D 1.18 0.96
148_Y 151_G 1.173 0.96
184_I 217_I 1.173 0.96
119_K 123_L 1.17 0.96
82_A 94_W 1.168 0.96
103_F 106_N 1.151 0.95
172_G 175_Q 1.127 0.95
67_N 115_D 1.117 0.94
52_N 66_L 1.115 0.94
205_G 208_N 1.112 0.94
67_N 119_K 1.103 0.94
75_K 83_L 1.093 0.94
22_D 25_G 1.09 0.93
19_V 136_Y 1.075 0.93
23_I 66_L 1.073 0.93
31_Q 61_D 1.056 0.92
128_E 137_A 1.055 0.92
66_L 71_F 1.053 0.92
29_L 206_S 1.051 0.92
21_G 202_I 1.05 0.92
17_I 129_I 1.049 0.92
107_D 116_L 1.043 0.91
81_M 161_W 1.039 0.91
17_I 45_L 1.033 0.91
36_Q 111_Q 1.027 0.90
29_L 209_S 1.024 0.90
26_E 206_S 1.019 0.90
40_F 43_I 1.016 0.90
79_E 83_L 1.015 0.90
54_D 99_G 1.008 0.89
19_V 217_I 1.008 0.89
75_K 160_L 1.006 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2qjcA10.97251000.38Contact Map0.792
2dfjA20.89911000.391Contact Map0.824
1g5bA30.99081000.41Contact Map0.8
4j6oA20.93581000.439Contact Map0.795
2z72A10.95871000.481Contact Map0.83
3icfA20.93581000.527Contact Map0.764
3h63A20.93581000.545Contact Map0.823
4i5lC20.917499.90.56Contact Map0.8
3e7aA20.912899.90.564Contact Map0.794
4il1A40.912899.90.565Contact Map0.749
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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