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OPENSEQ.org
YFJV - Putative arsenical pump membrane protein (Fragment)
UniProt: P52137 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13208
Length: 338 (335)
Sequences: 4222
Seq/Len: 12.60
YFJV
Paralog alert: 0.72 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: ARSB CITT TTDT YBHI YBIR YFJV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
212_E 216_G 3.791 1.00
143_L 164_G 2.788 1.00
307_T 310_Y 2.728 1.00
49_V 295_W 2.661 1.00
123_P 126_A 2.579 1.00
11_G 27_L 2.548 1.00
80_S 83_Q 2.426 1.00
64_I 74_A 2.42 1.00
309_G 313_R 2.208 1.00
181_G 185_R 2.203 1.00
179_N 182_K 2.191 1.00
310_Y 313_R 2.168 1.00
50_M 54_F 2.126 1.00
320_V 324_F 2.081 1.00
13_A 17_L 2.08 1.00
225_G 228_A 1.998 1.00
134_R 138_I 1.995 1.00
131_A 135_A 1.965 1.00
19_A 22_G 1.964 1.00
82_A 86_S 1.934 1.00
31_V 52_A 1.894 1.00
7_K 31_V 1.878 1.00
242_S 319_T 1.863 1.00
15_D 59_A 1.857 1.00
286_P 296_L 1.782 1.00
85_A 89_I 1.77 1.00
101_I 105_L 1.752 1.00
105_L 108_R 1.74 1.00
235_F 323_L 1.725 1.00
122_T 125_S 1.721 1.00
217_V 221_L 1.717 1.00
5_T 100_L 1.713 1.00
213_Y 217_V 1.703 1.00
98_A 325_V 1.664 1.00
238_A 319_T 1.642 1.00
19_A 23_A 1.641 1.00
53_G 295_W 1.633 1.00
86_S 90_S 1.616 1.00
62_P 89_I 1.613 1.00
273_A 277_G 1.612 1.00
139_V 164_G 1.6 1.00
46_L 310_Y 1.583 1.00
231_F 327_L 1.577 1.00
58_T 95_A 1.576 1.00
62_P 92_D 1.572 1.00
65_V 81_F 1.553 1.00
239_F 243_V 1.537 1.00
312_F 316_I 1.535 1.00
11_G 56_A 1.514 1.00
45_T 49_V 1.504 1.00
83_Q 86_S 1.489 1.00
273_A 330_L 1.486 1.00
284_I 319_T 1.466 1.00
69_V 289_S 1.458 1.00
328_A 332_W 1.457 1.00
149_F 152_P 1.453 1.00
237_T 253_G 1.452 1.00
15_D 20_N 1.441 1.00
12_A 92_D 1.436 1.00
205_L 210_F 1.436 1.00
142_L 167_V 1.424 1.00
93_A 97_A 1.422 1.00
145_V 149_F 1.401 0.99
309_G 312_F 1.393 0.99
216_G 220_L 1.391 0.99
60_S 66_S 1.375 0.99
195_S 247_M 1.372 0.99
8_V 55_I 1.371 0.99
241_S 246_N 1.369 0.99
203_Y 207_N 1.369 0.99
60_S 67_N 1.359 0.99
83_Q 268_E 1.354 0.99
91_V 325_V 1.353 0.99
250_V 278_C 1.344 0.99
98_A 321_P 1.341 0.99
95_A 322_V 1.341 0.99
216_G 219_N 1.34 0.99
90_S 93_A 1.338 0.99
208_A 255_L 1.334 0.99
63_L 66_S 1.333 0.99
59_A 66_S 1.322 0.99
149_F 153_Q 1.312 0.99
275_V 279_D 1.309 0.99
139_V 167_V 1.306 0.99
139_V 168_L 1.301 0.99
69_V 247_M 1.296 0.99
49_V 52_A 1.29 0.99
284_I 316_I 1.281 0.99
226_L 230_T 1.277 0.99
53_G 291_A 1.276 0.99
137_W 141_L 1.258 0.99
122_T 126_A 1.256 0.99
58_T 99_T 1.248 0.99
21_D 67_N 1.24 0.98
316_I 320_V 1.232 0.98
68_L 247_M 1.226 0.98
59_A 96_I 1.216 0.98
55_I 59_A 1.212 0.98
102_M 321_P 1.208 0.98
68_L 282_P 1.207 0.98
206_R 212_E 1.203 0.98
101_I 104_Y 1.2 0.98
59_A 63_L 1.2 0.98
72_V 254_A 1.197 0.98
205_L 211_T 1.189 0.98
222_A 232_G 1.182 0.98
147_F 164_G 1.178 0.98
84_Y 147_F 1.169 0.97
45_T 48_F 1.167 0.97
69_V 279_D 1.166 0.97
283_K 292_T 1.16 0.97
197_G 201_V 1.159 0.97
135_A 171_V 1.155 0.97
10_L 27_L 1.149 0.97
138_I 142_L 1.141 0.97
9_L 13_A 1.14 0.97
254_A 275_V 1.13 0.97
258_D 262_A 1.125 0.97
121_K 125_S 1.123 0.97
102_M 318_M 1.122 0.97
136_G 140_L 1.12 0.96
261_T 270_M 1.117 0.96
72_V 251_L 1.116 0.96
235_F 239_F 1.11 0.96
237_T 278_C 1.11 0.96
20_N 60_S 1.11 0.96
247_M 289_S 1.108 0.96
135_A 177_S 1.108 0.96
239_F 316_I 1.102 0.96
46_L 50_M 1.101 0.96
242_S 284_I 1.098 0.96
332_W 335_S 1.097 0.96
234_G 273_A 1.083 0.96
147_F 161_A 1.07 0.95
29_P 33_A 1.064 0.95
94_A 98_A 1.059 0.95
18_F 23_A 1.052 0.95
184_L 193_I 1.048 0.94
19_A 247_M 1.044 0.94
217_V 220_L 1.042 0.94
127_I 133_F 1.042 0.94
240_L 249_T 1.041 0.94
111_I 120_L 1.04 0.94
53_G 57_D 1.04 0.94
227_W 331_A 1.038 0.94
247_M 290_L 1.034 0.94
102_M 105_L 1.034 0.94
202_V 296_L 1.029 0.94
246_N 288_G 1.025 0.93
310_Y 314_T 1.022 0.93
234_G 277_G 1.022 0.93
94_A 325_V 1.021 0.93
13_A 16_A 1.016 0.93
69_V 250_V 1.014 0.93
135_A 138_I 1.012 0.93
199_Y 251_L 1.001 0.92
20_N 66_S 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.94671000.374Contact Map0.624
4ainA30.363916.10.954Contact Map0.311
3qnqA40.37877.50.96Contact Map0.477
1j4nA10.39356.20.962Contact Map0.229
1ldfA10.38465.80.962Contact Map0.374
4c7rA30.38764.80.963Contact Map0.336
2rddB10.10653.90.965Contact Map0.748
2b6oA10.38763.60.966Contact Map0.223
3tdsE50.29593.20.966Contact Map0.581
2wswA10.29293.20.967Contact Map0.38
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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