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YGGW - Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW
UniProt: P52062 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12983
Length: 378 (372)
Sequences: 3028
Seq/Len: 8.14
YGGW
Paralog alert: 0.56 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: HEMN YGGW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
44_L 83_G 4.042 1.00
41_Q 79_T 3.364 1.00
44_L 79_T 2.965 1.00
187_N 243_K 2.904 1.00
181_R 227_L 2.899 1.00
48_D 87_R 2.773 1.00
177_L 223_Q 2.749 1.00
361_T 364_G 2.743 1.00
153_S 189_P 2.677 1.00
141_G 144_E 2.643 1.00
352_T 359_Q 2.408 1.00
121_I 152_A 2.379 1.00
130_E 143_Q 2.353 1.00
19_K 27_S 2.245 1.00
150_K 154_G 2.234 1.00
42_H 291_M 2.231 1.00
226_Q 230_A 2.224 1.00
13_I 72_L 2.199 1.00
107_A 154_G 2.183 1.00
345_A 371_L 2.179 1.00
90_L 94_A 2.175 1.00
11_I 84_V 2.173 1.00
73_S 76_A 2.151 1.00
39_Y 265_C 2.1 1.00
110_F 152_A 2.092 1.00
48_D 83_G 2.084 1.00
40_V 44_L 2.079 1.00
146_K 182_Q 2.043 1.00
78_Q 82_D 2.031 1.00
130_E 142_P 2.028 1.00
176_A 224_G 2.022 1.00
128_F 183_A 2.011 1.00
78_Q 115_R 1.969 1.00
286_H 289_G 1.964 1.00
129_S 175_E 1.945 1.00
37_D 76_A 1.93 1.00
40_V 80_L 1.916 1.00
47_L 84_V 1.899 1.00
47_L 263_I 1.894 1.00
143_Q 147_R 1.891 1.00
37_D 79_T 1.872 1.00
64_I 80_L 1.865 1.00
184_I 231_A 1.862 1.00
303_E 306_D 1.846 1.00
193_W 224_G 1.825 1.00
45_N 48_D 1.809 1.00
188_P 233_Y 1.804 1.00
213_D 216_A 1.784 1.00
182_Q 185_E 1.757 1.00
125_V 145_A 1.75 1.00
184_I 227_L 1.72 1.00
98_M 118_V 1.717 1.00
114_Q 157_L 1.701 1.00
159_S 246_Y 1.683 1.00
177_L 181_R 1.68 1.00
269_G 281_T 1.633 1.00
174_E 177_L 1.627 1.00
178_G 181_R 1.623 1.00
227_L 231_A 1.617 1.00
74_G 112_D 1.605 1.00
162_L 183_A 1.589 1.00
40_V 76_A 1.578 1.00
345_A 374_L 1.577 1.00
8_S 253_N 1.574 1.00
147_R 150_K 1.573 1.00
46_D 283_K 1.565 1.00
177_L 227_L 1.558 1.00
225_H 241_Y 1.544 1.00
178_G 182_Q 1.54 1.00
112_D 116_A 1.539 1.00
167_G 217_L 1.53 1.00
173_L 223_Q 1.507 1.00
9_L 59_V 1.501 1.00
70_S 113_Y 1.489 1.00
62_I 90_L 1.487 0.99
360_I 368_L 1.479 0.99
234_Q 244_P 1.472 0.99
132_K 175_E 1.452 0.99
107_A 151_L 1.451 0.99
131_E 175_E 1.436 0.99
146_K 150_K 1.433 0.99
172_S 175_E 1.422 0.99
216_A 219_D 1.422 0.99
131_E 134_K 1.417 0.99
181_R 185_E 1.407 0.99
110_F 155_L 1.407 0.99
64_I 77_M 1.39 0.99
78_Q 116_A 1.374 0.99
160_F 189_P 1.359 0.99
153_S 187_N 1.349 0.99
48_D 86_A 1.346 0.99
36_H 73_S 1.332 0.99
132_K 179_D 1.326 0.99
130_E 134_K 1.323 0.99
308_P 327_F 1.314 0.98
84_V 90_L 1.312 0.98
58_E 91_A 1.311 0.98
144_E 147_R 1.304 0.98
159_S 189_P 1.303 0.98
111_V 115_R 1.29 0.98
109_R 113_Y 1.288 0.98
173_L 177_L 1.276 0.98
40_V 83_G 1.275 0.98
26_N 266_G 1.274 0.98
98_M 113_Y 1.264 0.98
142_P 146_K 1.262 0.98
9_L 263_I 1.261 0.98
151_L 154_G 1.261 0.98
256_R 320_E 1.261 0.98
129_S 132_K 1.252 0.98
125_V 128_F 1.245 0.98
43_L 263_I 1.244 0.98
131_E 170_D 1.238 0.98
234_Q 247_Q 1.235 0.97
180_L 227_L 1.23 0.97
215_D 219_D 1.228 0.97
128_F 179_D 1.224 0.97
72_L 76_A 1.223 0.97
312_F 322_A 1.223 0.97
103_G 139_I 1.221 0.97
123_I 152_A 1.22 0.97
324_R 353_E 1.216 0.97
323_P 326_E 1.215 0.97
282_T 298_S 1.213 0.97
287_P 291_M 1.208 0.97
44_L 48_D 1.207 0.97
153_S 160_F 1.207 0.97
173_L 216_A 1.201 0.97
136_L 168_L 1.201 0.97
343_D 346_I 1.187 0.97
40_V 72_L 1.187 0.97
77_M 116_A 1.181 0.96
268_H 282_T 1.181 0.96
311_F 331_T 1.18 0.96
344_E 374_L 1.174 0.96
173_L 220_I 1.169 0.96
153_S 188_P 1.168 0.96
152_A 160_F 1.166 0.96
228_L 233_Y 1.164 0.96
252_L 256_R 1.16 0.96
252_L 318_L 1.157 0.96
343_D 347_A 1.155 0.96
191_L 228_L 1.155 0.96
324_R 357_Y 1.155 0.96
360_I 371_L 1.152 0.96
288_R 292_Q 1.149 0.96
319_L 365_K 1.149 0.96
173_L 219_D 1.142 0.95
368_L 372_L 1.138 0.95
142_P 182_Q 1.136 0.95
127_S 132_K 1.134 0.95
316_F 358_W 1.132 0.95
265_C 287_P 1.131 0.95
273_F 277_R 1.126 0.95
259_D 270_K 1.119 0.95
315_R 322_A 1.116 0.95
309_F 376_L 1.109 0.94
183_A 191_L 1.107 0.94
107_A 111_V 1.106 0.94
119_N 159_S 1.105 0.94
121_I 157_L 1.104 0.94
47_L 87_R 1.099 0.94
313_M 372_L 1.097 0.94
226_Q 362_E 1.095 0.94
223_Q 227_L 1.095 0.94
13_I 265_C 1.089 0.94
70_S 100_A 1.088 0.94
129_S 178_G 1.082 0.93
262_G 269_G 1.076 0.93
74_G 109_R 1.074 0.93
348_Q 363_H 1.07 0.93
325_V 329_A 1.063 0.93
111_V 155_L 1.053 0.92
250_H 254_Y 1.049 0.92
170_D 210_V 1.048 0.92
195_Q 217_L 1.042 0.92
82_D 86_A 1.037 0.91
149_A 186_L 1.036 0.91
262_G 267_A 1.027 0.91
149_A 160_F 1.026 0.91
187_N 233_Y 1.021 0.91
9_L 84_V 1.018 0.90
325_V 356_D 1.017 0.90
340_P 343_D 1.009 0.90
189_P 246_Y 1.007 0.90
28_H 287_P 1.005 0.90
149_A 153_S 1.004 0.90
37_D 75_P 1.003 0.90
223_Q 226_Q 1.003 0.90
70_S 98_M 1 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1oltA10.98681000.286Contact Map0.743
1r30A20.78311000.751Contact Map0.502
4jc0A20.780499.90.761Contact Map0.559
2qgqA80.772599.90.767Contact Map0.674
3t7vA10.74699.90.784Contact Map0.547
3iixA10.775199.90.798Contact Map0.571
2yx0A10.629699.80.803Contact Map0.477
2z2uA10.632399.80.825Contact Map0.504
1tv8A20.822899.50.852Contact Map0.568
3c8fA10.584799.50.852Contact Map0.511
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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