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OPENSEQ.org
RTCA - RNA 3'-terminal phosphate cyclase
UniProt: P46849 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12938
Length: 338 (327)
Sequences: 525
Seq/Len: 1.61
RTCA
Paralog alert: 0.11 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
263_A 267_V 3.284 1.00
27_M 78_F 3.125 1.00
23_L 58_A 2.578 1.00
257_V 265_Q 2.57 1.00
55_V 76_L 2.459 1.00
133_D 157_H 2.413 1.00
6_A 34_T 2.306 1.00
140_E 150_Q 2.252 0.99
34_T 75_R 2.203 0.99
289_V 316_V 2.122 0.99
109_L 116_S 1.983 0.98
208_E 234_N 1.982 0.98
126_N 129_A 1.943 0.98
305_P 309_L 1.905 0.97
280_V 288_L 1.758 0.95
195_V 208_E 1.723 0.95
52_L 69_A 1.703 0.94
207_R 260_E 1.679 0.94
193_G 238_L 1.669 0.93
58_A 104_T 1.648 0.93
317_E 323_R 1.645 0.93
196_L 235_T 1.638 0.93
190_Q 241_E 1.628 0.92
16_G 50_Q 1.627 0.92
313_I 324_F 1.607 0.92
131_P 237_S 1.604 0.92
282_E 306_S 1.578 0.91
264_A 268_K 1.576 0.91
92_I 101_V 1.567 0.90
152_T 166_V 1.565 0.90
102_L 169_T 1.52 0.88
11_Q 314_A 1.503 0.88
289_V 302_V 1.488 0.87
188_I 242_S 1.478 0.86
105_V 118_V 1.468 0.86
258_S 262_V 1.452 0.85
91_A 121_S 1.45 0.85
121_S 166_V 1.448 0.85
117_R 170_E 1.439 0.84
151_Q 170_E 1.43 0.84
112_A 116_S 1.416 0.83
279_A 301_T 1.401 0.82
95_A 123_G 1.398 0.82
285_A 309_L 1.387 0.81
19_L 23_L 1.383 0.81
159_F 198_A 1.364 0.80
288_L 300_F 1.351 0.79
158_G 161_P 1.35 0.79
295_A 298_G 1.34 0.78
256_R 262_V 1.337 0.78
26_S 65_T 1.335 0.78
142_L 284_L 1.329 0.77
293_A 320_L 1.327 0.77
124_T 165_G 1.319 0.77
161_P 164_G 1.304 0.75
211_T 263_A 1.299 0.75
125_D 157_H 1.289 0.74
251_V 266_L 1.284 0.74
209_I 223_I 1.271 0.73
98_C 132_A 1.268 0.73
53_T 101_V 1.265 0.72
278_A 303_A 1.246 0.71
17_Q 95_A 1.243 0.70
33_F 319_F 1.241 0.70
111_F 289_V 1.236 0.70
316_V 320_L 1.234 0.70
163_G 233_G 1.226 0.69
286_D 308_H 1.224 0.69
45_P 164_G 1.212 0.68
27_M 58_A 1.204 0.67
53_T 56_K 1.203 0.67
68_G 73_S 1.197 0.66
92_I 120_V 1.196 0.66
85_G 114_G 1.192 0.66
57_A 90_F 1.191 0.66
308_H 311_T 1.191 0.66
17_Q 308_H 1.188 0.65
58_A 88_Y 1.182 0.65
193_G 235_T 1.182 0.65
23_L 55_V 1.179 0.64
158_G 163_G 1.179 0.64
48_L 71_L 1.179 0.64
20_R 103_Q 1.169 0.63
15_G 38_I 1.166 0.63
117_R 168_A 1.163 0.63
32_P 262_V 1.161 0.63
240_V 270_V 1.161 0.63
17_Q 66_V 1.156 0.62
131_P 156_R 1.151 0.62
212_L 267_V 1.149 0.62
26_S 286_D 1.149 0.62
88_Y 116_S 1.148 0.61
235_T 263_A 1.145 0.61
24_S 28_I 1.143 0.61
55_V 101_V 1.139 0.61
19_L 38_I 1.138 0.60
85_G 113_D 1.135 0.60
207_R 233_G 1.134 0.60
242_S 274_L 1.132 0.60
39_R 47_L 1.132 0.60
134_F 138_V 1.131 0.60
146_I 180_L 1.127 0.59
307_C 310_L 1.126 0.59
278_A 301_T 1.126 0.59
15_G 39_R 1.125 0.59
51_H 96_G 1.124 0.59
29_T 320_L 1.123 0.59
163_G 207_R 1.117 0.58
267_V 271_K 1.115 0.58
208_E 262_V 1.113 0.58
134_F 281_G 1.11 0.58
204_V 234_N 1.11 0.58
53_T 90_F 1.108 0.57
17_Q 286_D 1.105 0.57
61_I 116_S 1.105 0.57
21_S 312_N 1.097 0.56
62_C 81_G 1.09 0.55
23_L 33_F 1.09 0.55
16_G 123_G 1.089 0.55
219_H 240_V 1.089 0.55
204_V 262_V 1.088 0.55
26_S 293_A 1.088 0.55
192_R 241_E 1.086 0.55
89_R 121_S 1.082 0.55
231_G 260_E 1.076 0.54
87_D 117_R 1.074 0.54
242_S 245_I 1.074 0.54
314_A 317_E 1.073 0.54
273_Y 282_E 1.072 0.54
285_A 306_S 1.071 0.53
98_C 167_V 1.068 0.53
156_R 166_V 1.064 0.53
265_Q 269_E 1.058 0.52
110_W 148_I 1.054 0.52
9_G 14_G 1.053 0.52
158_G 165_G 1.052 0.51
103_Q 287_Q 1.051 0.51
126_N 134_F 1.049 0.51
27_M 62_C 1.043 0.51
154_L 194_E 1.043 0.51
289_V 313_I 1.043 0.51
164_G 233_G 1.042 0.50
133_D 278_A 1.041 0.50
56_K 69_A 1.037 0.50
317_E 324_F 1.036 0.50
159_F 196_L 1.032 0.49
303_A 309_L 1.031 0.49
108_A 238_L 1.03 0.49
57_A 101_V 1.022 0.48
34_T 136_R 1.022 0.48
28_I 108_A 1.022 0.48
134_F 248_R 1.019 0.48
60_E 272_R 1.016 0.48
285_A 298_G 1.015 0.48
199_G 232_P 1.012 0.47
13_E 17_Q 1.011 0.47
307_C 326_L 1.009 0.47
207_R 259_A 1.009 0.47
131_P 159_F 1.007 0.47
153_T 168_A 1.004 0.46
146_I 178_N 1.003 0.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tutA111000.023Contact Map0.606
3pqvA40.99111000.132Contact Map0.619
2o0bA10.819592.60.949Contact Map0.459
3r38A10.7811920.95Contact Map0.406
2yvwA10.763391.40.951Contact Map0.379
3zh4A10.7663910.952Contact Map0.454
3rmtA40.813690.90.952Contact Map0.41
3nvsA10.579977.10.96Contact Map0.583
2la7A10.233723.10.972Contact Map0.186
2pqcA10.218916.40.974Contact Map0.527
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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