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OPENSEQ.org
YEDJ - Uncharacterized protein YedJ
UniProt: P46144 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12710
Length: 231 (211)
Sequences: 623
Seq/Len: 2.95
YEDJ
Paralog alert: 0.02 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
179_L 205_M 3.536 1.00
144_S 170_A 3.255 1.00
40_L 189_R 3.192 1.00
189_R 192_Q 2.334 1.00
138_A 141_F 2.303 1.00
124_Q 186_Q 2.3 1.00
37_A 51_I 2.236 1.00
185_M 194_A 2.23 1.00
181_L 185_M 2.137 1.00
53_T 100_V 2.096 1.00
171_L 205_M 2.059 1.00
51_I 123_V 2.056 1.00
43_D 192_Q 2.033 1.00
199_H 203_E 2.002 1.00
182_P 198_A 1.999 1.00
34_W 52_L 1.848 0.99
124_Q 128_R 1.83 0.99
41_A 46_V 1.804 0.99
208_L 212_L 1.799 0.99
169_Y 172_D 1.772 0.99
149_V 170_A 1.759 0.99
200_F 204_F 1.743 0.99
185_M 190_G 1.73 0.99
150_A 153_D 1.721 0.98
93_P 96_K 1.677 0.98
186_Q 190_G 1.656 0.98
11_E 34_W 1.62 0.97
10_F 53_T 1.59 0.97
182_P 195_Q 1.582 0.97
10_F 13_W 1.563 0.97
178_L 201_L 1.543 0.96
132_L 140_V 1.535 0.96
49_L 96_K 1.531 0.96
200_F 207_K 1.503 0.96
141_F 145_G 1.502 0.96
198_A 202_V 1.467 0.95
34_W 38_Q 1.458 0.95
34_W 56_Y 1.429 0.94
44_D 189_R 1.419 0.93
38_Q 52_L 1.399 0.93
102_H 106_A 1.387 0.92
196_H 207_K 1.384 0.92
195_Q 199_H 1.373 0.92
107_H 120_A 1.367 0.92
118_T 121_K 1.357 0.91
106_A 120_A 1.356 0.91
41_A 48_M 1.311 0.89
65_K 108_S 1.297 0.89
179_L 198_A 1.293 0.88
144_S 149_V 1.288 0.88
53_T 92_F 1.283 0.88
21_Q 24_A 1.279 0.88
37_A 123_V 1.268 0.87
13_W 84_L 1.264 0.87
132_L 198_A 1.252 0.86
200_F 203_E 1.249 0.86
24_A 186_Q 1.238 0.85
82_R 100_V 1.229 0.85
206_A 210_A 1.218 0.84
179_L 194_A 1.211 0.84
180_K 184_T 1.184 0.82
92_F 96_K 1.173 0.81
61_V 77_A 1.166 0.80
41_A 45_D 1.164 0.80
171_L 208_L 1.146 0.79
203_E 207_K 1.139 0.78
23_A 142_A 1.136 0.78
124_Q 173_H 1.128 0.77
154_G 212_L 1.128 0.77
109_F 180_K 1.128 0.77
210_A 215_E 1.121 0.77
43_D 189_R 1.116 0.76
83_R 87_E 1.116 0.76
193_L 196_H 1.106 0.75
196_H 210_A 1.103 0.75
128_R 174_F 1.096 0.74
14_L 18_H 1.091 0.74
86_R 94_A 1.083 0.73
103_A 107_H 1.083 0.73
173_H 181_L 1.076 0.72
62_S 73_S 1.06 0.71
51_I 151_L 1.057 0.70
94_A 98_E 1.054 0.70
23_A 186_Q 1.048 0.69
190_G 193_L 1.046 0.69
175_Q 205_M 1.046 0.69
138_A 181_L 1.039 0.68
47_D 96_K 1.038 0.68
53_T 56_Y 1.036 0.68
128_R 173_H 1.035 0.68
144_S 172_D 1.034 0.68
173_H 179_L 1.033 0.68
203_E 206_A 1.033 0.68
159_A 164_L 1.033 0.68
174_F 179_L 1.027 0.67
81_T 85_L 1.013 0.66
46_V 51_I 1.012 0.65
79_E 83_R 1.012 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3gw7A211000.331Contact Map0.514
2pjqA40.93941000.384Contact Map0.678
2qgsA20.93071000.393Contact Map0.678
3dtoA40.93071000.404Contact Map0.685
3djbA20.93071000.405Contact Map0.634
3b57A10.89181000.406Contact Map0.717
2pq7A10.90911000.416Contact Map0.614
2q14A80.943799.60.792Contact Map0.448
2cqzA60.714399.60.799Contact Map0.522
2hekA20.917799.40.816Contact Map0.607
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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