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OPENSEQ.org
HEXR - HTH-type transcriptional regulator HexR
UniProt: P46118 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12860
Length: 289 (278)
Sequences: 2667
Seq/Len: 9.59
HEXR
Paralog alert: 0.77 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: HEXR MURR RPIR YFHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
207_A 219_A 3.687 1.00
129_K 176_G 3.449 1.00
121_A 206_I 3.397 1.00
187_R 214_P 3.144 1.00
121_A 221_L 3.127 1.00
181_L 195_A 3.037 1.00
11_L 23_E 2.885 1.00
60_T 69_H 2.857 1.00
199_R 220_T 2.818 1.00
123_D 257_R 2.719 1.00
146_A 150_F 2.718 1.00
195_A 205_V 2.664 1.00
28_S 31_N 2.637 1.00
122_V 253_G 2.449 1.00
124_L 204_M 2.363 1.00
178_V 206_I 2.265 1.00
24_V 28_S 2.24 1.00
22_A 54_F 2.175 1.00
133_F 146_A 2.135 1.00
103_M 107_D 2.098 1.00
223_I 246_V 2.073 1.00
180_V 208_L 2.069 1.00
55_C 66_F 2.044 1.00
129_K 177_D 1.938 1.00
195_A 215_L 1.927 1.00
196_Q 218_E 1.916 1.00
125_L 180_V 1.911 1.00
124_L 221_L 1.906 1.00
18_E 57_S 1.883 1.00
35_S 43_E 1.856 1.00
182_I 208_L 1.851 1.00
198_A 203_A 1.825 1.00
146_A 180_V 1.801 1.00
11_L 19_R 1.795 1.00
173_C 203_A 1.789 1.00
143_A 182_I 1.758 1.00
23_E 27_A 1.75 1.00
89_D 97_K 1.732 1.00
120_R 221_L 1.698 1.00
133_F 150_F 1.686 1.00
61_R 65_D 1.67 1.00
204_M 220_T 1.665 1.00
124_L 178_V 1.663 1.00
146_A 247_I 1.661 1.00
181_L 205_V 1.611 1.00
130_K 156_P 1.586 1.00
15_S 57_S 1.583 1.00
21_V 54_F 1.576 1.00
258_R 261_K 1.574 1.00
40_M 63_F 1.566 1.00
99_F 106_L 1.555 1.00
207_A 222_A 1.547 1.00
142_V 247_I 1.547 1.00
114_D 117_A 1.545 1.00
126_T 254_F 1.536 1.00
133_F 143_A 1.534 1.00
109_V 226_D 1.532 1.00
32_A 70_L 1.53 1.00
117_A 120_R 1.527 1.00
174_S 177_D 1.52 1.00
133_F 180_V 1.518 1.00
40_M 51_V 1.49 1.00
125_L 178_V 1.489 1.00
52_N 62_G 1.488 1.00
125_L 131_I 1.476 1.00
31_N 43_E 1.473 1.00
179_V 198_A 1.47 1.00
173_C 179_V 1.468 1.00
201_N 268_R 1.46 1.00
181_L 191_L 1.448 1.00
17_S 50_T 1.448 1.00
63_F 67_K 1.437 1.00
19_R 23_E 1.425 1.00
60_T 66_F 1.422 0.99
21_V 44_A 1.421 0.99
128_A 178_V 1.42 0.99
25_I 66_F 1.414 0.99
117_A 121_A 1.385 0.99
182_I 247_I 1.385 0.99
126_T 258_R 1.382 0.99
193_E 196_Q 1.348 0.99
132_A 173_C 1.338 0.99
96_G 110_R 1.325 0.99
124_L 206_I 1.32 0.99
21_V 50_T 1.314 0.99
133_F 157_V 1.313 0.99
131_I 155_V 1.313 0.99
173_C 177_D 1.313 0.99
179_V 203_A 1.305 0.99
37_I 51_V 1.303 0.99
37_I 52_N 1.302 0.99
90_S 93_S 1.274 0.99
68_L 71_A 1.27 0.99
119_N 253_G 1.269 0.99
144_H 161_D 1.26 0.98
225_L 243_Q 1.252 0.98
183_S 215_L 1.245 0.98
142_V 182_I 1.244 0.98
122_V 257_R 1.243 0.98
126_T 257_R 1.239 0.98
102_A 248_D 1.229 0.98
104_A 107_D 1.223 0.98
121_A 250_L 1.21 0.98
147_M 157_V 1.209 0.98
3_M 7_I 1.195 0.98
10_Q 13_H 1.194 0.98
145_D 149_K 1.19 0.98
130_K 177_D 1.187 0.98
123_D 127_Q 1.181 0.97
11_L 22_A 1.167 0.97
24_V 35_S 1.167 0.97
117_A 221_L 1.158 0.97
138_S 236_P 1.155 0.97
236_P 239_S 1.146 0.97
129_K 174_S 1.146 0.97
207_A 215_L 1.141 0.97
134_F 179_V 1.133 0.97
31_N 35_S 1.122 0.96
20_K 45_N 1.12 0.96
155_V 254_F 1.12 0.96
225_L 246_V 1.117 0.96
5_E 9_S 1.117 0.96
18_E 21_V 1.106 0.96
164_V 190_N 1.097 0.96
145_D 240_R 1.091 0.95
54_F 58_M 1.089 0.95
205_V 219_A 1.087 0.95
24_V 44_A 1.078 0.95
130_K 158_V 1.073 0.95
128_A 131_I 1.071 0.95
150_F 254_F 1.066 0.95
17_S 20_K 1.063 0.94
183_S 186_G 1.054 0.94
216_A 222_A 1.052 0.94
38_A 48_E 1.047 0.94
192_V 207_A 1.043 0.94
37_I 41_A 1.03 0.93
99_F 245_T 1.019 0.93
197_L 200_E 1.017 0.93
109_V 242_A 1.012 0.92
44_A 49_P 1.005 0.92
7_I 54_F 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ivnA20.94461000.205Contact Map0.861
3shoA40.64011000.556Contact Map0.877
2xhzA40.619499.90.589Contact Map0.835
3fxaA40.681799.90.594Contact Map0.863
3etnA40.726699.90.601Contact Map0.774
1m3sA20.612599.90.606Contact Map0.812
1jeoA10.602199.90.609Contact Map0.748
1vimA40.657499.90.613Contact Map0.865
3iwfA20.366899.90.615Contact Map0.832
2o3fA30.366899.90.616Contact Map0.746
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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