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OPENSEQ.org
MTGA - Monofunctional biosynthetic peptidoglycan transglycosylase
UniProt: P46022 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12808
Length: 242 (225)
Sequences: 1059
Seq/Len: 4.71
MTGA
Paralog alert: 0.06 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
184_K 193_E 7.479 1.00
175_E 185_P 5.133 1.00
76_M 174_V 4.68 1.00
175_E 186_A 2.648 1.00
86_Q 226_Q 2.628 1.00
85_D 91_H 2.612 1.00
152_W 160_V 2.512 1.00
124_A 148_I 2.509 1.00
120_S 145_T 2.505 1.00
74_P 77_G 2.235 1.00
69_M 77_G 2.154 1.00
79_A 227_M 2.122 1.00
94_F 145_T 2.017 1.00
80_V 201_L 1.956 1.00
91_H 149_E 1.892 1.00
165_A 201_L 1.853 1.00
127_L 164_I 1.841 1.00
87_K 95_D 1.818 1.00
179_Q 183_H 1.775 1.00
178_A 186_A 1.734 1.00
175_E 179_Q 1.724 1.00
102_A 106_N 1.706 0.99
222_W 226_Q 1.706 0.99
71_Q 187_S 1.682 0.99
199_A 223_I 1.673 0.99
89_P 155_K 1.612 0.99
196_L 220_Q 1.596 0.99
68_S 71_Q 1.564 0.99
73_S 186_A 1.558 0.99
167_F 197_L 1.535 0.99
67_V 72_I 1.51 0.98
98_S 114_R 1.493 0.98
177_A 197_L 1.485 0.98
105_H 114_R 1.438 0.98
76_M 194_A 1.435 0.98
166_E 170_G 1.412 0.97
178_A 194_A 1.411 0.97
149_E 157_I 1.395 0.97
44_V 131_D 1.394 0.97
185_P 188_K 1.389 0.97
171_V 180_R 1.375 0.97
177_A 181_Y 1.341 0.96
109_N 113_I 1.331 0.96
48_R 51_S 1.324 0.96
54_L 57_N 1.323 0.95
80_V 162_L 1.315 0.95
79_A 162_L 1.296 0.95
69_M 159_T 1.292 0.95
156_R 159_T 1.283 0.94
77_G 155_K 1.275 0.94
215_Y 219_R 1.258 0.94
182_F 196_L 1.254 0.94
56_G 59_R 1.243 0.93
81_I 158_L 1.228 0.93
168_G 171_V 1.225 0.92
73_S 76_M 1.224 0.92
14_R 17_L 1.219 0.92
220_Q 224_L 1.218 0.92
15_F 19_L 1.218 0.92
23_L 27_W 1.205 0.92
87_K 90_E 1.193 0.91
80_V 198_A 1.174 0.90
81_I 89_P 1.165 0.90
203_N 206_R 1.164 0.90
17_L 22_V 1.164 0.90
16_L 19_L 1.153 0.89
15_F 18_R 1.118 0.87
75_W 194_A 1.116 0.87
69_M 155_K 1.116 0.87
24_A 28_G 1.111 0.87
46_V 50_V 1.11 0.87
54_L 58_F 1.108 0.86
79_A 198_A 1.107 0.86
83_A 222_W 1.099 0.86
136_V 139_G 1.098 0.86
35_S 153_S 1.091 0.85
214_G 218_S 1.087 0.85
55_H 58_F 1.077 0.84
94_F 120_S 1.066 0.83
144_L 147_G 1.062 0.83
225_R 229_Q 1.06 0.83
145_T 149_E 1.054 0.82
225_R 228_Y 1.054 0.82
14_R 22_V 1.045 0.82
64_S 164_I 1.042 0.81
72_I 81_I 1.04 0.81
124_A 128_F 1.039 0.81
93_G 115_G 1.021 0.80
87_K 97_A 1.019 0.79
33_L 37_A 1.017 0.79
106_N 133_R 1.015 0.79
49_Q 52_A 1.008 0.78
19_L 22_V 1.006 0.78
73_S 194_A 1.006 0.78
66_W 159_T 1.005 0.78
145_T 223_I 1.005 0.78
126_N 137_R 1.002 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jchA10.91321000.205Contact Map0
3vmtA20.94631000.217Contact Map0.781
3fwmA10.99591000.232Contact Map0.704
3udfA20.89671000.236Contact Map0.705
2oqoA10.81821000.239Contact Map0.746
2olvA20.88431000.247Contact Map0.693
3hzsA10.81821000.254Contact Map0.808
3zg7B10.40081000.633Contact Map0.85
3zg7A10.194298.10.891Contact Map0.809
2y2mA10.247993.70.932Contact Map0.079
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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