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OPENSEQ.org

YHBO - Protein YhbO
UniProt: P45470 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12784
Length: 172 (168)
Sequences: 6890
Seq/Len: 41.01

YHBO
Paralog alert: 0.67 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: YAJL YHBO
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
4_K 31_E 2.887 1.00
145_V 169_L 2.775 1.00
120_K 137_E 2.756 1.00
165_E 168_R 2.72 1.00
119_R 147_K 2.7 1.00
120_K 139_Y 2.669 1.00
6_A 35_I 2.502 1.00
33_I 66_F 2.432 1.00
6_A 66_F 2.39 1.00
117_R 135_G 2.368 1.00
119_R 146_D 2.232 1.00
24_E 167_L 2.17 1.00
116_I 121_L 2.037 1.00
128_I 132_K 1.946 1.00
33_I 56_K 1.94 1.00
4_K 33_I 1.89 1.00
119_R 150_L 1.744 1.00
42_T 53_T 1.712 1.00
145_V 165_E 1.712 1.00
36_E 39_A 1.709 1.00
57_S 60_E 1.692 1.00
121_L 136_A 1.654 1.00
94_V 100_V 1.648 1.00
13_F 45_G 1.643 1.00
131_V 138_F 1.625 1.00
59_D 85_R 1.567 1.00
28_A 167_L 1.56 1.00
93_F 98_K 1.53 1.00
22_A 26_R 1.51 1.00
88_T 91_R 1.509 1.00
151_V 169_L 1.507 1.00
102_A 152_T 1.486 1.00
94_V 148_D 1.486 1.00
5_I 68_A 1.466 1.00
15_D 19_T 1.448 1.00
119_R 148_D 1.445 1.00
120_K 146_D 1.437 1.00
111_I 136_A 1.414 1.00
92_D 96_S 1.39 0.99
11_D 44_K 1.386 0.99
130_D 133_N 1.369 0.99
37_K 83_D 1.36 0.99
99_P 169_L 1.337 0.99
88_T 92_D 1.329 0.99
91_R 95_N 1.326 0.99
7_V 22_A 1.317 0.99
68_A 99_P 1.312 0.99
9_I 18_F 1.288 0.99
94_V 150_L 1.278 0.99
9_I 34_T 1.272 0.99
145_V 151_V 1.27 0.99
153_S 158_D 1.269 0.99
85_R 88_T 1.262 0.99
63_P 92_D 1.253 0.99
84_N 88_T 1.249 0.99
131_V 136_A 1.239 0.98
97_G 148_D 1.228 0.98
87_V 113_A 1.226 0.98
62_T 65_E 1.223 0.98
102_A 110_L 1.214 0.98
13_F 18_F 1.205 0.98
16_S 20_S 1.205 0.98
87_V 91_R 1.202 0.98
107_P 123_A 1.201 0.98
25_F 163_N 1.2 0.98
8_L 86_F 1.195 0.98
67_D 98_K 1.183 0.98
94_V 115_V 1.175 0.98
7_V 70_L 1.174 0.98
44_K 51_S 1.148 0.97
5_I 30_H 1.147 0.97
22_A 34_T 1.133 0.97
20_S 160_P 1.132 0.97
89_F 93_F 1.13 0.97
18_F 34_T 1.125 0.97
142_E 161_A 1.121 0.97
165_E 169_L 1.116 0.96
13_F 52_V 1.097 0.96
42_T 51_S 1.096 0.96
97_G 100_V 1.088 0.96
51_S 55_D 1.087 0.96
9_I 13_F 1.087 0.96
23_D 27_K 1.083 0.96
20_S 23_D 1.07 0.95
101_F 162_F 1.053 0.95
125_K 138_F 1.044 0.94
92_D 95_N 1.028 0.94
122_T 144_V 1.018 0.93
108_Q 130_D 1.007 0.93
71_L 109_L 1.003 0.93
151_V 162_F 1.003 0.93
143_V 165_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fseA20.98841000.067Contact Map0.872
1oi4A20.98841000.08Contact Map0.85
3noqA20.96511000.085Contact Map0.704
3ewnA10.97671000.087Contact Map0.741
4hcjA10.98261000.087Contact Map0.757
3graA20.96511000.093Contact Map0.756
2ab0A20.97671000.099Contact Map0.75
2rk3A10.98841000.1Contact Map0.742
2vrnA20.98261000.1Contact Map0.841
3mgkA20.97091000.1Contact Map0.724

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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