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OPENSEQ.org
NANK - N-acetylmannosamine kinase
UniProt: P45425 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12815
Length: 291 (287)
Sequences: 5489
Seq/Len: 19.13
NANK
Paralog alert: 0.81 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: ALSK MAK MLC NAGC NAGK NANK YPHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
19_G 23_Q 3.539 1.00
103_I 145_T 3.167 1.00
87_P 90_K 3.028 1.00
27_R 276_D 2.954 1.00
148_G 233_D 2.695 1.00
168_C 173_C 2.615 1.00
174_V 224_L 2.582 1.00
125_V 228_I 2.549 1.00
46_S 95_L 2.53 1.00
110_A 136_G 2.438 1.00
58_R 286_A 2.437 1.00
16_A 279_L 2.328 1.00
119_G 124_M 2.323 1.00
126_F 240_G 2.253 1.00
122_T 236_C 2.249 1.00
4_L 49_V 2.213 1.00
236_C 269_L 2.209 1.00
18_I 283_A 2.198 1.00
157_T 227_D 2.177 1.00
166_C 173_C 2.151 1.00
90_K 94_Q 2.098 1.00
110_A 138_V 2.069 1.00
219_R 256_Y 2.055 1.00
89_V 93_E 2.054 1.00
59_V 96_T 2.04 1.00
215_H 252_L 2.037 1.00
43_D 95_L 1.999 1.00
139_S 144_L 1.98 1.00
103_I 108_A 1.97 1.00
222_A 256_Y 1.936 1.00
5_A 279_L 1.927 1.00
123_D 235_Q 1.916 1.00
225_I 237_V 1.892 1.00
116_A 284_L 1.891 1.00
103_I 107_Q 1.879 1.00
218_A 222_A 1.855 1.00
156_H 168_C 1.842 1.00
166_C 169_G 1.801 1.00
109_A 126_F 1.794 1.00
112_A 273_Y 1.786 1.00
15_A 48_L 1.768 1.00
127_I 225_I 1.72 1.00
133_V 178_A 1.703 1.00
61_I 92_L 1.674 1.00
218_A 253_V 1.644 1.00
91_T 94_Q 1.628 1.00
218_A 252_L 1.628 1.00
229_K 257_L 1.623 1.00
147_P 235_Q 1.619 1.00
86_F 91_T 1.618 1.00
156_H 173_C 1.6 1.00
28_R 51_P 1.594 1.00
186_A 216_R 1.585 1.00
250_L 270_A 1.561 1.00
125_V 137_V 1.536 1.00
165_V 171_T 1.536 1.00
257_L 268_L 1.531 1.00
202_R 207_D 1.518 1.00
62_A 108_A 1.494 1.00
256_Y 259_Q 1.493 1.00
254_E 258_A 1.448 1.00
250_L 254_E 1.44 1.00
187_A 210_A 1.424 1.00
12_K 180_G 1.42 1.00
113_E 117_L 1.419 1.00
114_F 124_M 1.416 1.00
129_V 221_L 1.409 1.00
223_R 227_D 1.404 0.99
156_H 166_C 1.403 0.99
122_T 235_Q 1.394 0.99
6_I 15_A 1.379 0.99
158_L 227_D 1.372 0.99
33_P 44_A 1.364 0.99
146_G 151_A 1.352 0.99
195_D 198_T 1.352 0.99
228_I 231_T 1.322 0.99
5_A 60_A 1.314 0.99
183_I 217_S 1.313 0.99
50_S 95_L 1.306 0.99
197_K 201_T 1.302 0.99
187_A 213_L 1.301 0.99
37_T 40_A 1.295 0.99
201_T 205_Q 1.293 0.99
110_A 124_M 1.292 0.99
229_K 237_V 1.286 0.99
59_V 98_L 1.281 0.99
215_H 255_T 1.281 0.99
236_C 267_D 1.277 0.99
43_D 47_A 1.262 0.99
46_S 96_T 1.233 0.98
247_E 251_A 1.226 0.98
16_A 24_I 1.221 0.98
15_A 52_L 1.214 0.98
164_P 177_I 1.214 0.98
87_P 91_T 1.204 0.98
124_M 138_V 1.187 0.98
123_D 144_L 1.176 0.98
117_L 121_I 1.157 0.97
146_G 233_D 1.142 0.97
50_S 96_T 1.139 0.97
255_T 259_Q 1.139 0.97
203_A 206_G 1.138 0.97
118_D 272_H 1.136 0.97
106_A 128_T 1.132 0.97
124_M 238_V 1.131 0.97
204_G 248_G 1.126 0.97
169_G 173_C 1.122 0.97
215_H 256_Y 1.122 0.97
46_S 50_S 1.11 0.96
198_T 202_R 1.103 0.96
6_I 49_V 1.102 0.96
63_S 67_I 1.098 0.96
123_D 139_S 1.091 0.96
108_A 282_A 1.09 0.96
117_L 120_D 1.09 0.96
130_S 242_S 1.089 0.96
28_R 48_L 1.088 0.96
93_E 100_T 1.086 0.96
5_A 282_A 1.084 0.96
92_L 100_T 1.083 0.96
114_F 138_V 1.082 0.96
12_K 29_E 1.07 0.95
252_L 256_Y 1.064 0.95
26_D 52_L 1.061 0.95
10_G 131_T 1.061 0.95
222_A 226_A 1.057 0.95
62_A 278_G 1.053 0.95
137_V 144_L 1.045 0.94
251_A 255_T 1.039 0.94
107_Q 143_L 1.036 0.94
103_I 285_L 1.033 0.94
115_Q 284_L 1.024 0.93
252_L 255_T 1.018 0.93
42_R 91_T 1.017 0.93
200_F 214_I 1.014 0.93
137_V 152_G 1.014 0.93
247_E 270_A 1.012 0.93
104_N 153_H 1.01 0.93
60_A 108_A 1.01 0.93
256_Y 260_E 1.007 0.93
6_I 45_L 1.007 0.93
225_I 239_V 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z05A10.98971000.126Contact Map0.707
1z6rA40.99311000.128Contact Map0.753
2aa4A20.98971000.13Contact Map0.782
3vovA40.99311000.137Contact Map0.835
3vglA10.98971000.155Contact Map0.754
2yhwA10.98281000.161Contact Map0.786
2ap1A10.98631000.163Contact Map0.745
2qm1A40.99311000.164Contact Map0.827
4db3A10.98631000.166Contact Map0.695
4ijaA20.97591000.168Contact Map0.723
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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