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OPENSEQ.org
YHCG - Uncharacterized protein YhcG
UniProt: P45423 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12813
Length: 375 (338)
Sequences: 562
Seq/Len: 1.66
YHCG
Paralog alert: 0.19 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
85_K 108_G 5.117 1.00
105_T 142_S 3.907 1.00
298_M 321_V 3.498 1.00
264_N 289_K 3.459 1.00
107_S 142_S 3.081 1.00
142_S 170_V 2.843 1.00
262_D 327_G 2.799 1.00
258_R 265_W 2.784 1.00
284_D 298_M 2.691 1.00
84_A 88_R 2.631 1.00
103_H 127_K 2.603 1.00
264_N 327_G 2.561 1.00
104_Q 108_G 2.527 1.00
105_T 170_V 2.32 1.00
89_Q 104_Q 2.309 1.00
263_D 327_G 2.217 0.99
232_E 256_Q 2.207 0.99
20_I 77_R 2.197 0.99
293_S 297_Q 2.068 0.99
275_R 280_L 2.019 0.99
302_L 317_P 1.995 0.98
150_V 155_A 1.979 0.98
258_R 267_R 1.944 0.98
50_V 95_L 1.913 0.98
24_D 78_Y 1.87 0.97
289_K 325_E 1.834 0.97
278_R 313_D 1.818 0.97
88_R 103_H 1.814 0.97
50_V 94_Y 1.812 0.97
259_L 268_V 1.809 0.96
353_D 356_R 1.768 0.96
29_E 37_L 1.763 0.96
284_D 321_V 1.735 0.95
288_G 294_D 1.7 0.95
320_L 331_A 1.667 0.94
306_K 317_P 1.633 0.93
294_D 297_Q 1.614 0.92
275_R 278_R 1.609 0.92
275_R 314_E 1.607 0.92
273_F 314_E 1.599 0.92
306_K 310_T 1.598 0.92
282_I 305_A 1.592 0.92
84_A 108_G 1.572 0.91
12_Y 73_D 1.554 0.90
253_V 275_R 1.539 0.90
254_G 257_R 1.535 0.90
303_N 337_G 1.535 0.90
47_R 51_E 1.512 0.89
331_A 344_A 1.502 0.88
107_S 170_V 1.493 0.88
23_V 41_T 1.492 0.88
217_L 235_L 1.487 0.87
155_A 183_E 1.464 0.86
89_Q 108_G 1.457 0.86
54_Q 91_R 1.429 0.85
354_E 358_A 1.418 0.84
142_S 146_R 1.415 0.84
139_L 163_T 1.406 0.83
16_H 70_L 1.398 0.83
38_M 42_Y 1.396 0.83
291_S 294_D 1.386 0.82
306_K 340_N 1.381 0.82
172_Q 176_Q 1.374 0.81
292_Y 300_M 1.37 0.81
97_F 160_E 1.37 0.81
307_E 336_A 1.368 0.81
30_T 34_V 1.361 0.80
345_S 349_M 1.36 0.80
68_K 84_A 1.359 0.80
84_A 103_H 1.345 0.79
303_N 336_A 1.344 0.79
226_Y 231_F 1.324 0.78
86_N 90_M 1.323 0.78
146_R 174_E 1.316 0.77
231_F 287_V 1.315 0.77
240_M 255_R 1.313 0.77
246_L 272_F 1.308 0.77
24_D 77_R 1.306 0.76
82_F 90_M 1.303 0.76
26_A 41_T 1.302 0.76
276_R 311_L 1.293 0.75
16_H 73_D 1.293 0.75
91_R 95_L 1.265 0.73
105_T 140_P 1.26 0.73
172_Q 175_R 1.256 0.72
299_N 338_L 1.253 0.72
295_A 299_N 1.251 0.72
180_Q 183_E 1.249 0.72
308_H 333_Y 1.249 0.72
299_N 334_A 1.239 0.71
266_F 330_E 1.238 0.71
235_L 246_L 1.236 0.71
49_I 53_E 1.233 0.70
304_Y 308_H 1.232 0.70
104_Q 107_S 1.213 0.69
22_L 41_T 1.199 0.67
281_L 320_L 1.193 0.67
155_A 182_Y 1.189 0.66
264_N 291_S 1.179 0.65
274_H 344_A 1.177 0.65
179_T 184_R 1.166 0.64
106_M 147_L 1.166 0.64
196_Q 200_P 1.158 0.63
85_K 103_H 1.151 0.63
34_V 38_M 1.151 0.63
257_R 309_W 1.148 0.62
30_T 33_S 1.147 0.62
327_G 345_S 1.145 0.62
306_K 336_A 1.145 0.62
354_E 357_L 1.143 0.62
237_N 240_M 1.129 0.60
251_A 320_L 1.125 0.60
104_Q 145_V 1.122 0.60
280_L 305_A 1.118 0.59
166_C 345_S 1.112 0.59
18_G 48_R 1.111 0.59
50_V 91_R 1.106 0.58
295_A 302_L 1.105 0.58
140_P 170_V 1.101 0.58
39_T 227_S 1.1 0.57
96_F 156_R 1.098 0.57
271_L 305_A 1.095 0.57
337_G 340_N 1.095 0.57
85_K 148_L 1.094 0.57
280_L 314_E 1.093 0.57
299_N 337_G 1.093 0.57
355_K 359_D 1.093 0.57
266_F 307_E 1.083 0.56
352_P 355_K 1.071 0.54
16_H 220_L 1.071 0.54
275_R 311_L 1.069 0.54
310_T 317_P 1.067 0.54
147_L 160_E 1.066 0.54
162_E 165_R 1.064 0.54
50_V 54_Q 1.064 0.54
152_N 183_E 1.059 0.53
299_N 303_N 1.057 0.53
73_D 254_G 1.056 0.53
77_R 345_S 1.055 0.53
150_V 160_E 1.045 0.52
261_I 292_Y 1.044 0.52
282_I 317_P 1.04 0.51
102_I 106_M 1.039 0.51
16_H 19_I 1.037 0.51
60_A 67_I 1.034 0.50
65_Q 68_K 1.032 0.50
41_T 45_I 1.028 0.50
303_N 340_N 1.022 0.49
92_L 96_F 1.006 0.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vldA20.61071000.8Contact Map0.465
3h1tA10.40842.40.975Contact Map0.493
1vz0A80.386721.30.979Contact Map0.38
2inbA10.325318.40.979Contact Map0.418
3vejA20.10415.10.98Contact Map0.076
2k7rA10.253314.50.98Contact Map0.242
2jv8A10.16279.30.982Contact Map0
2iu4A20.27475.40.984Contact Map0.12
3u9wA10.1924.90.984Contact Map0.353
2acvA20.21874.40.984Contact Map0.179
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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