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OPENSEQ.org
KDSD - Arabinose 5-phosphate isomerase KdsD
UniProt: P45395 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12803
Length: 328 (318)
Sequences: 1029
Seq/Len: 3.24
KDSD
Paralog alert: 0.31 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: GUTQ KDSD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
63_I 168_L 4.427 1.00
108_E 136_S 3.595 1.00
128_C 141_A 3.486 1.00
18_E 180_K 3.185 1.00
52_V 76_T 3.048 1.00
228_A 273_I 2.893 1.00
57_M 84_G 2.72 1.00
253_F 273_I 2.712 1.00
67_M 71_F 2.663 1.00
103_I 167_T 2.64 1.00
221_K 250_E 2.612 1.00
54_V 64_G 2.601 1.00
282_I 300_R 2.59 1.00
147_V 170_M 2.549 1.00
20_L 169_V 2.525 1.00
222_T 274_A 2.509 1.00
70_T 175_A 2.405 1.00
49_K 97_Q 2.378 1.00
33_Y 146_C 2.321 1.00
13_Q 34_I 2.288 1.00
241_V 306_M 2.285 1.00
231_E 235_K 2.272 1.00
52_V 101_I 2.241 1.00
147_V 167_T 2.24 1.00
306_M 313_L 2.216 1.00
24_R 27_L 2.215 1.00
57_M 83_P 2.191 1.00
272_S 275_D 2.189 1.00
249_I 313_L 2.181 1.00
303_T 318_H 1.999 1.00
44_K 143_V 1.979 1.00
100_V 119_L 1.954 1.00
24_R 31_D 1.951 1.00
48_C 99_V 1.94 1.00
207_N 287_G 1.937 1.00
55_M 102_A 1.924 1.00
249_I 306_M 1.829 0.99
21_A 31_D 1.812 0.99
64_G 103_I 1.801 0.99
51_K 95_T 1.799 0.99
244_D 248_M 1.777 0.99
41_A 127_I 1.755 0.99
284_V 288_I 1.707 0.99
24_R 169_V 1.653 0.98
131_G 146_C 1.645 0.98
41_A 143_V 1.627 0.98
25_E 28_A 1.618 0.98
44_K 125_P 1.615 0.98
24_R 28_A 1.606 0.98
45_M 52_V 1.585 0.98
55_M 100_V 1.576 0.97
82_H 85_E 1.571 0.97
81_V 94_V 1.569 0.97
68_A 78_S 1.568 0.97
67_M 101_I 1.551 0.97
130_T 144_H 1.53 0.97
22_I 162_S 1.528 0.97
26_C 162_S 1.497 0.96
206_V 293_A 1.489 0.96
13_Q 17_K 1.451 0.95
12_F 181_A 1.411 0.94
33_Y 148_K 1.408 0.94
72_A 93_M 1.402 0.94
16_G 38_F 1.395 0.94
52_V 71_F 1.387 0.94
295_N 299_S 1.38 0.93
67_M 103_I 1.367 0.93
253_F 258_L 1.364 0.93
54_V 101_I 1.36 0.93
213_G 235_K 1.355 0.92
255_D 259_R 1.355 0.92
46_F 181_A 1.354 0.92
129_I 170_M 1.339 0.92
103_I 129_I 1.339 0.92
218_H 241_V 1.333 0.92
125_P 142_D 1.324 0.91
21_A 25_E 1.324 0.91
45_M 76_T 1.312 0.91
121_R 289_L 1.306 0.91
109_S 112_I 1.299 0.90
267_D 270_Q 1.287 0.90
221_K 274_A 1.281 0.89
209_I 290_A 1.28 0.89
209_I 317_L 1.278 0.89
21_A 28_A 1.273 0.89
15_A 18_E 1.266 0.89
45_M 48_C 1.265 0.89
13_Q 39_T 1.257 0.88
288_I 292_E 1.254 0.88
228_A 240_T 1.249 0.88
43_E 47_W 1.247 0.88
161_T 176_V 1.242 0.87
221_K 279_P 1.239 0.87
74_T 178_L 1.238 0.87
120_K 142_D 1.231 0.87
261_V 276_V 1.231 0.87
206_V 284_V 1.226 0.86
94_V 100_V 1.225 0.86
237_L 316_V 1.225 0.86
45_M 99_V 1.222 0.86
42_C 174_L 1.214 0.86
51_K 93_M 1.204 0.85
29_E 150_A 1.199 0.85
15_A 19_V 1.197 0.85
62_H 81_V 1.195 0.85
68_A 72_A 1.194 0.84
294_L 326_G 1.188 0.84
284_V 305_V 1.185 0.84
37_N 40_L 1.172 0.83
190_A 200_R 1.168 0.83
219_V 242_I 1.165 0.82
219_V 240_T 1.151 0.81
110_S 114_A 1.15 0.81
87_A 195_G 1.147 0.81
18_E 22_I 1.141 0.81
129_I 147_V 1.14 0.81
247_M 313_L 1.136 0.80
128_C 144_H 1.136 0.80
211_H 321_D 1.134 0.80
12_F 39_T 1.128 0.80
79_F 93_M 1.122 0.79
131_G 147_V 1.105 0.78
253_F 276_V 1.096 0.77
19_V 177_A 1.094 0.77
239_M 252_I 1.092 0.76
112_I 137_M 1.09 0.76
138_A 144_H 1.089 0.76
26_C 150_A 1.086 0.76
239_M 316_V 1.083 0.76
64_G 167_T 1.082 0.75
247_M 250_E 1.074 0.75
219_V 223_A 1.067 0.74
128_C 137_M 1.066 0.74
225_L 273_I 1.066 0.74
231_E 234_R 1.065 0.74
122_L 192_S 1.061 0.73
256_G 260_R 1.055 0.73
44_K 99_V 1.055 0.73
225_L 228_A 1.037 0.71
23_E 153_A 1.035 0.71
220_K 245_D 1.034 0.71
43_E 279_P 1.034 0.71
131_G 149_V 1.034 0.71
72_A 79_F 1.032 0.70
204_L 294_L 1.03 0.70
62_H 86_A 1.03 0.70
30_L 166_A 1.027 0.70
284_V 307_V 1.025 0.70
225_L 253_F 1.023 0.69
222_T 273_I 1.022 0.69
304_S 318_H 1.02 0.69
231_E 240_T 1.016 0.69
221_K 245_D 1.008 0.68
18_E 151_K 1.007 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fxaA40.60061000.728Contact Map0.794
3etnA40.63111000.737Contact Map0.729
3c3jA60.91461000.751Contact Map0.473
3fj1A40.91161000.752Contact Map0.553
3euaA80.84151000.752Contact Map0.486
2xhzA40.55791000.753Contact Map0.83
3hbaA20.88411000.756Contact Map0.569
2bplA30.9391000.758Contact Map0.577
3fkjA20.88111000.759Contact Map0.476
2pocA40.93291000.763Contact Map0.557
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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