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OPENSEQ.org
UUP - ABC transporter ATP-binding protein uup
UniProt: P43672 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13134
Length: 635 (629)
Sequences: 6077
Seq/Len: 9.66
UUP
Paralog alert: 0.90 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
100_R 119_E 4.796 1.00
217_R 239_D 4.606 1.00
324_D 337_D 4.499 1.00
583_K 610_D 4.081 1.00
8_G 21_N 4.043 1.00
322_M 325_V 3.563 1.00
323_E 375_R 3.354 1.00
397_D 439_R 3.288 1.00
342_V 348_I 3.239 1.00
6_M 9_A 3.197 1.00
569_E 624_R 3.148 1.00
327_Y 372_D 3.124 1.00
324_D 339_S 3.085 1.00
131_N 134_Q 3.045 1.00
267_E 271_R 2.96 1.00
46_M 209_I 2.747 1.00
398_K 406_E 2.698 1.00
501_D 524_H 2.622 1.00
576_L 617_E 2.574 1.00
127_L 132_L 2.501 1.00
82_S 85_D 2.5 1.00
613_A 617_E 2.482 1.00
17_P 20_D 2.45 1.00
346_D 506_E 2.385 1.00
322_M 340_A 2.342 1.00
103_D 107_L 2.337 1.00
573_L 621_A 2.309 1.00
395_D 398_K 2.297 1.00
362_L 493_V 2.289 1.00
403_N 453_R 2.287 1.00
318_I 377_H 2.268 1.00
270_I 285_V 2.253 1.00
80_E 155_S 2.244 1.00
328_Q 372_D 2.209 1.00
326_C 373_S 2.205 1.00
366_L 463_I 2.177 1.00
327_Y 364_L 2.158 1.00
97_Y 123_V 2.14 1.00
522_G 525_D 2.098 1.00
587_L 607_V 2.094 1.00
333_Q 336_K 2.088 1.00
240_Q 244_E 2.077 1.00
20_D 230_K 2.072 1.00
92_E 96_E 2.062 1.00
33_C 216_I 2.058 1.00
364_L 371_A 2.039 1.00
325_V 371_A 2.031 1.00
93_E 126_Q 2.031 1.00
256_N 260_D 2.024 1.00
84_Y 139_I 2.022 1.00
11_L 53_Q 2.021 1.00
364_L 376_I 2.012 1.00
152_V 156_S 2.006 1.00
7_H 59_R 1.998 1.00
222_R 233_T 1.998 1.00
584_L 614_A 1.975 1.00
348_I 508_W 1.972 1.00
580_L 621_A 1.941 1.00
10_W 57_D 1.938 1.00
615_E 619_E 1.931 1.00
220_A 223_I 1.93 1.00
438_V 449_L 1.916 1.00
9_A 55_L 1.911 1.00
69_A 170_A 1.908 1.00
48_I 60_I 1.902 1.00
363_K 368_Q 1.899 1.00
324_D 373_S 1.897 1.00
240_Q 243_L 1.865 1.00
196_E 218_N 1.85 1.00
576_L 621_A 1.842 1.00
399_T 402_D 1.837 1.00
124_Q 128_D 1.823 1.00
126_Q 130_H 1.82 1.00
483_I 490_V 1.818 1.00
603_Q 606_K 1.811 1.00
320_F 461_L 1.787 1.00
33_C 223_I 1.786 1.00
326_C 337_D 1.768 1.00
232_V 248_A 1.766 1.00
321_E 341_Q 1.759 1.00
322_M 376_I 1.75 1.00
335_V 338_F 1.745 1.00
268_V 271_R 1.715 1.00
138_R 174_N 1.715 1.00
321_E 377_H 1.713 1.00
590_Q 603_Q 1.711 1.00
100_R 103_D 1.702 1.00
153_A 156_S 1.701 1.00
580_L 614_A 1.696 1.00
572_Q 576_L 1.688 1.00
275_K 278_R 1.685 1.00
587_L 614_A 1.685 1.00
6_M 24_L 1.683 1.00
436_T 440_A 1.68 1.00
10_W 21_N 1.674 1.00
262_K 265_Q 1.674 1.00
433_R 436_T 1.672 1.00
6_M 49_L 1.669 1.00
577_L 618_L 1.659 1.00
583_K 586_A 1.64 1.00
30_E 222_R 1.636 1.00
102_H 105_S 1.63 1.00
261_R 264_A 1.623 1.00
200_K 218_N 1.616 1.00
459_S 486_Y 1.613 1.00
349_A 504_V 1.603 1.00
401_M 420_V 1.594 1.00
285_V 289_K 1.587 1.00
567_Q 571_E 1.571 1.00
323_E 377_H 1.562 1.00
584_L 611_M 1.56 1.00
588_Q 615_E 1.559 1.00
71_L 170_A 1.551 1.00
247_E 250_R 1.539 1.00
622_F 626_E 1.539 1.00
327_Y 369_L 1.537 1.00
19_L 22_A 1.534 1.00
385_A 459_S 1.529 1.00
104_I 116_N 1.522 1.00
588_Q 611_M 1.522 1.00
253_E 257_A 1.521 1.00
606_K 610_D 1.512 1.00
131_N 138_R 1.51 1.00
609_A 613_A 1.509 1.00
96_E 100_R 1.507 1.00
570_L 628_L 1.505 1.00
11_L 48_I 1.505 1.00
282_E 285_V 1.501 1.00
398_K 403_N 1.496 1.00
84_Y 88_A 1.495 1.00
323_E 339_S 1.473 1.00
506_E 518_R 1.473 1.00
97_Y 126_Q 1.472 1.00
568_R 571_E 1.471 1.00
397_D 437_P 1.471 1.00
99_K 103_D 1.468 1.00
79_V 155_S 1.465 1.00
7_H 61_I 1.455 1.00
62_Y 68_V 1.451 1.00
600_P 603_Q 1.451 1.00
197_G 201_T 1.447 1.00
349_A 500_V 1.446 1.00
260_D 263_L 1.443 1.00
43_S 47_K 1.442 1.00
602_E 606_K 1.421 1.00
52_E 72_Q 1.417 0.99
586_A 590_Q 1.417 0.99
582_A 586_A 1.412 0.99
8_G 23_E 1.41 0.99
578_E 582_A 1.404 0.99
256_N 259_F 1.399 0.99
576_L 579_D 1.398 0.99
157_L 165_A 1.381 0.99
174_N 203_N 1.377 0.99
243_L 247_E 1.376 0.99
81_G 85_D 1.375 0.99
359_T 363_K 1.363 0.99
278_R 281_N 1.363 0.99
617_E 620_Q 1.359 0.99
492_L 504_V 1.352 0.99
69_A 175_P 1.349 0.99
170_A 178_L 1.345 0.99
383_E 457_K 1.344 0.99
224_V 231_L 1.333 0.99
99_K 102_H 1.328 0.99
11_L 44_T 1.327 0.99
26_I 32_V 1.326 0.99
463_I 491_L 1.325 0.99
100_R 104_I 1.321 0.99
579_D 583_K 1.32 0.99
584_L 618_L 1.319 0.99
225_D 241_Y 1.316 0.99
237_N 240_Q 1.313 0.99
225_D 245_K 1.311 0.99
619_E 623_E 1.308 0.99
47_K 52_E 1.307 0.99
81_G 89_E 1.295 0.99
48_I 55_L 1.283 0.99
620_Q 624_R 1.28 0.99
24_L 224_V 1.275 0.99
575_Q 578_E 1.273 0.99
283_G 286_R 1.272 0.99
93_E 96_E 1.269 0.99
104_I 123_V 1.267 0.99
266_E 269_W 1.264 0.99
584_L 615_E 1.26 0.99
226_L 231_L 1.254 0.98
605_Q 609_A 1.25 0.98
580_L 618_L 1.25 0.98
8_G 57_D 1.249 0.98
326_C 336_K 1.247 0.98
5_S 25_H 1.245 0.98
583_K 614_A 1.245 0.98
63_E 66_L 1.244 0.98
270_I 288_L 1.243 0.98
345_G 489_T 1.242 0.98
401_M 434_A 1.24 0.98
87_V 143_L 1.233 0.98
325_V 376_I 1.232 0.98
577_L 581_E 1.232 0.98
122_K 126_Q 1.232 0.98
610_D 613_A 1.232 0.98
620_Q 623_E 1.229 0.98
340_A 508_W 1.226 0.98
251_V 255_Q 1.222 0.98
492_L 500_V 1.221 0.98
585_E 589_T 1.218 0.98
80_E 153_A 1.218 0.98
31_R 221_T 1.216 0.98
510_F 516_I 1.216 0.98
49_L 207_I 1.209 0.98
30_E 221_T 1.208 0.98
590_Q 607_V 1.202 0.98
98_L 102_H 1.2 0.98
224_V 233_T 1.197 0.98
328_Q 333_Q 1.197 0.98
371_A 376_I 1.197 0.98
581_E 618_L 1.187 0.98
177_V 205_T 1.186 0.98
580_L 584_L 1.184 0.98
403_N 438_V 1.179 0.97
34_L 226_L 1.175 0.97
624_R 628_L 1.173 0.97
333_Q 514_G 1.173 0.97
614_A 617_E 1.172 0.97
85_D 88_A 1.17 0.97
250_R 254_L 1.17 0.97
196_E 497_R 1.16 0.97
611_M 615_E 1.158 0.97
610_D 614_A 1.157 0.97
81_G 86_F 1.156 0.97
96_E 99_K 1.155 0.97
246_E 250_R 1.152 0.97
363_K 369_L 1.149 0.97
396_P 439_R 1.142 0.97
617_E 621_A 1.141 0.97
590_Q 593_D 1.138 0.97
154_L 165_A 1.138 0.97
125_E 129_H 1.135 0.97
197_G 200_K 1.131 0.97
134_Q 138_R 1.13 0.96
234_Y 248_A 1.128 0.96
353_P 356_C 1.124 0.96
568_R 572_Q 1.123 0.96
262_K 266_E 1.122 0.96
626_E 630_A 1.118 0.96
364_L 370_Q 1.115 0.96
325_V 364_L 1.111 0.96
258_E 261_R 1.111 0.96
342_V 489_T 1.109 0.96
274_I 278_R 1.109 0.96
398_K 402_D 1.103 0.96
121_A 125_E 1.101 0.96
50_N 70_R 1.101 0.96
273_G 285_V 1.099 0.96
612_A 616_Q 1.099 0.96
608_L 612_A 1.099 0.96
135_L 172_V 1.099 0.96
247_E 251_V 1.095 0.96
623_E 627_Y 1.094 0.96
564_Y 568_R 1.092 0.96
500_V 504_V 1.088 0.95
402_D 405_A 1.086 0.95
97_Y 101_Y 1.082 0.95
208_F 220_A 1.081 0.95
128_D 133_W 1.08 0.95
84_Y 151_N 1.077 0.95
346_D 505_T 1.077 0.95
342_V 491_L 1.076 0.95
67_I 176_R 1.076 0.95
586_A 589_T 1.071 0.95
400_V 438_V 1.07 0.95
350_L 491_L 1.068 0.95
437_P 440_A 1.067 0.95
591_V 604_T 1.066 0.95
492_L 499_F 1.065 0.95
492_L 503_T 1.063 0.95
571_E 575_Q 1.061 0.95
316_G 379_G 1.06 0.94
274_I 277_R 1.06 0.94
623_E 630_A 1.057 0.94
27_E 30_E 1.057 0.94
584_L 588_Q 1.051 0.94
105_S 120_L 1.05 0.94
619_E 622_F 1.048 0.94
624_R 627_Y 1.048 0.94
336_K 515_K 1.048 0.94
425_Q 434_A 1.044 0.94
276_A 279_T 1.043 0.94
327_Y 360_T 1.041 0.94
263_L 288_L 1.035 0.94
7_H 23_E 1.035 0.94
26_I 177_V 1.034 0.93
578_E 581_E 1.033 0.93
348_I 491_L 1.03 0.93
616_Q 620_Q 1.028 0.93
82_S 153_A 1.025 0.93
236_G 240_Q 1.022 0.93
623_E 626_E 1.022 0.93
244_E 247_E 1.02 0.93
483_I 503_T 1.018 0.93
320_F 378_V 1.017 0.93
190_E 353_P 1.015 0.93
358_K 466_E 1.015 0.93
616_Q 619_E 1.014 0.93
280_R 287_A 1.013 0.93
612_A 615_E 1.01 0.92
365_M 376_I 1.009 0.92
46_M 179_L 1.007 0.92
94_Q 132_L 1.006 0.92
162_L 390_H 1.003 0.92
10_W 17_P 1.003 0.92
378_V 382_L 1.002 0.92
609_A 612_A 1.001 0.92
284_R 288_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4finA20.86461000.357Contact Map0.785
2iw3A20.69451000.478Contact Map0.774
3g5uA20.80311000.522Contact Map0.698
3bk7A10.77641000.525Contact Map0.605
1yqtA10.78581000.528Contact Map0.642
4f4cA10.79371000.53Contact Map0.75
3ozxA20.79691000.54Contact Map0.691
3j16B10.79691000.55Contact Map0.433
3ux8A10.73861000.583Contact Map0.593
2vf7A30.72281000.667Contact Map0.53
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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