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OPENSEQ.org
LPXH - UDP-2,3-diacylglucosamine hydrolase
UniProt: P43341 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12666
Length: 240 (240)
Sequences: 1016
Seq/Len: 4.23
LPXH
Paralog alert: 0.19 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
38_I 42_L 3.421 1.00
33_A 36_L 3.315 1.00
35_A 72_P 3.14 1.00
121_D 175_N 2.831 1.00
110_V 192_I 2.747 1.00
113_M 191_L 2.683 1.00
6_I 9_L 2.614 1.00
72_P 95_T 2.594 1.00
110_V 190_W 2.33 1.00
39_L 112_I 2.287 1.00
139_T 143_A 2.28 1.00
108_R 189_Q 2.261 1.00
104_E 110_V 2.209 1.00
184_E 207_N 2.118 1.00
38_I 63_I 2.012 1.00
4_L 29_E 1.925 1.00
203_E 208_Q 1.899 1.00
63_I 73_C 1.88 1.00
128_F 132_V 1.851 1.00
67_S 73_C 1.844 1.00
183_M 191_L 1.779 1.00
5_F 37_Y 1.774 1.00
217_G 224_S 1.732 0.99
76_I 100_E 1.656 0.99
4_L 227_K 1.649 0.99
35_A 74_Y 1.617 0.99
132_V 141_F 1.61 0.99
215_V 226_V 1.594 0.99
3_T 35_A 1.584 0.99
109_R 189_Q 1.561 0.98
229_T 232_D 1.557 0.98
23_L 62_A 1.526 0.98
4_L 33_A 1.523 0.98
17_A 21_G 1.502 0.98
113_M 117_T 1.488 0.98
24_R 28_G 1.485 0.98
201_V 235_L 1.473 0.97
178_A 181_S 1.471 0.97
75_F 94_M 1.459 0.97
62_A 69_S 1.422 0.97
229_T 234_E 1.421 0.97
27_A 62_A 1.419 0.97
53_N 56_H 1.414 0.97
6_I 22_F 1.41 0.97
201_V 213_R 1.395 0.96
49_D 149_R 1.367 0.96
201_V 215_V 1.36 0.95
76_I 112_I 1.349 0.95
122_D 125_Y 1.349 0.95
204_L 207_N 1.325 0.95
12_C 44_E 1.306 0.94
62_A 65_A 1.302 0.94
66_V 71_V 1.29 0.93
27_A 65_A 1.282 0.93
127_A 131_K 1.267 0.93
181_S 185_K 1.251 0.92
86_K 90_R 1.244 0.92
61_A 65_A 1.242 0.92
54_P 58_K 1.234 0.91
166_S 169_L 1.23 0.91
134_K 137_L 1.211 0.90
176_Q 204_L 1.208 0.90
45_A 48_G 1.208 0.90
216_L 226_V 1.198 0.90
60_A 88_F 1.191 0.89
172_M 192_I 1.179 0.89
34_D 72_P 1.179 0.89
132_V 138_Q 1.179 0.89
6_I 36_L 1.171 0.88
75_F 84_L 1.166 0.88
6_I 38_I 1.16 0.88
144_L 148_V 1.154 0.87
58_K 61_A 1.147 0.87
45_A 141_F 1.137 0.86
65_A 68_D 1.137 0.86
177_N 181_S 1.136 0.86
217_G 235_L 1.13 0.86
28_G 31_R 1.126 0.85
104_E 109_R 1.126 0.85
89_A 96_L 1.121 0.85
184_E 208_Q 1.115 0.85
137_L 140_L 1.107 0.84
2_A 232_D 1.102 0.84
189_Q 211_A 1.101 0.84
227_K 236_I 1.1 0.84
199_P 224_S 1.096 0.83
27_A 30_A 1.096 0.83
183_M 188_V 1.089 0.83
22_F 59_M 1.088 0.83
64_K 68_D 1.084 0.82
136_W 140_L 1.083 0.82
225_M 236_I 1.078 0.82
148_V 151_R 1.076 0.82
131_K 136_W 1.075 0.82
111_L 191_L 1.075 0.82
133_H 138_Q 1.069 0.81
45_A 83_L 1.067 0.81
179_V 188_V 1.062 0.81
123_A 127_A 1.057 0.80
3_T 106_Y 1.055 0.80
97_L 102_V 1.054 0.80
179_V 193_H 1.052 0.80
182_A 185_K 1.051 0.80
124_G 163_A 1.035 0.78
60_A 92_S 1.032 0.78
3_T 34_D 1.02 0.77
62_A 68_D 1.02 0.77
167_K 170_A 1.011 0.76
226_V 233_V 1.01 0.76
203_E 212_F 1.009 0.76
201_V 212_F 1.005 0.75
141_F 152_I 1.004 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3h63A20.908399.90.693Contact Map0.454
4i5lC20.912599.90.7Contact Map0.501
3e0jA40.895899.90.703Contact Map0.595
2z72A10.891799.90.709Contact Map0.565
2a22A20.683399.80.714Contact Map0.747
2kknA10.637599.80.714Contact Map0.538
1su1A40.683399.80.715Contact Map0.683
1z2wA20.645899.80.718Contact Map0.708
1nnwA20.862599.80.719Contact Map0.579
1s3lA20.645899.80.723Contact Map0.751
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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