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OPENSEQ.org
YRAH - Uncharacterized fimbrial-like protein YraH
UniProt: P42913 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12773
Length: 194 (179)
Sequences: 1293
Seq/Len: 7.22
YRAH
Paralog alert: 0.93 [within 20: 0.77] - ratio of genomes with paralogs
Cluster includes: ELFA FIMA1 FIMF FIMG FIMI SFMA SFMF YADN YBGD YCBU YCBV YDER YDES YFCP YFCV YGIL YRAH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
128_I 167_A 3.796 1.00
90_V 191_L 3.306 1.00
61_N 64_E 2.84 1.00
129_R 168_Y 2.611 1.00
129_R 170_V 2.47 1.00
131_D 168_Y 2.394 1.00
169_Y 183_A 2.362 1.00
41_N 76_V 2.337 1.00
124_T 179_T 2.303 1.00
112_L 127_G 2.29 1.00
39_E 77_N 2.287 1.00
113_A 141_L 2.207 1.00
125_G 178_I 2.151 1.00
72_T 162_N 2.151 1.00
60_R 64_E 2.083 1.00
115_V 183_A 2.074 1.00
41_N 44_D 2.054 1.00
35_K 56_A 1.885 1.00
113_A 187_V 1.805 1.00
59_F 171_S 1.796 1.00
41_N 74_P 1.707 1.00
51_L 183_A 1.697 1.00
65_R 168_Y 1.666 1.00
129_R 138_I 1.6 1.00
132_D 135_S 1.594 1.00
128_I 185_A 1.544 1.00
44_D 74_P 1.527 0.99
126_V 169_Y 1.463 0.99
92_A 163_V 1.463 0.99
52_G 67_P 1.457 0.99
70_P 166_I 1.443 0.99
132_D 137_N 1.411 0.99
37_A 161_V 1.383 0.99
47_I 189_V 1.382 0.99
65_R 129_R 1.379 0.99
52_G 183_A 1.375 0.99
33_I 54_Y 1.371 0.99
17_A 21_A 1.354 0.98
54_Y 66_S 1.337 0.98
105_T 111_N 1.31 0.98
123_A 126_V 1.309 0.98
106_V 172_T 1.307 0.98
51_L 169_Y 1.291 0.98
47_I 73_I 1.285 0.98
17_A 20_A 1.276 0.97
51_L 63_G 1.268 0.97
72_T 164_D 1.268 0.97
125_G 176_S 1.266 0.97
59_F 172_T 1.253 0.97
39_E 76_V 1.246 0.97
136_G 166_I 1.238 0.97
44_D 47_I 1.238 0.97
59_F 126_V 1.236 0.97
148_N 151_Y 1.232 0.97
74_P 162_N 1.225 0.97
65_R 170_V 1.185 0.96
11_G 14_A 1.18 0.95
32_E 53_H 1.174 0.95
113_A 128_I 1.167 0.95
139_M 165_L 1.159 0.95
7_T 11_G 1.157 0.95
4_V 7_T 1.155 0.95
112_L 170_V 1.153 0.95
25_G 189_V 1.135 0.94
30_D 130_I 1.126 0.94
54_Y 169_Y 1.123 0.94
131_D 136_G 1.12 0.94
70_P 164_D 1.118 0.93
59_F 178_I 1.113 0.93
4_V 12_L 1.104 0.93
6_K 9_I 1.104 0.93
51_L 129_R 1.1 0.93
113_A 185_A 1.095 0.93
68_K 168_Y 1.093 0.92
103_N 113_A 1.083 0.92
171_S 178_I 1.071 0.91
33_I 167_A 1.05 0.90
28_V 46_K 1.039 0.90
103_N 106_V 1.037 0.90
28_V 186_I 1.032 0.89
122_A 182_E 1.025 0.89
25_G 29_F 1.021 0.89
93_S 192_D 1.009 0.88
8_A 15_L 1.009 0.88
7_T 10_A 1.004 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jmrA10.78351000.256Contact Map0.584
2jtyA10.81441000.275Contact Map0.674
2xg5B10.8661000.28Contact Map0.644
2uy6B20.80931000.297Contact Map0.765
1pdkB10.78871000.308Contact Map0.628
3bwuF10.716599.90.36Contact Map0.774
4dwhB20.721699.90.362Contact Map0.727
2w07B10.737199.90.385Contact Map0.639
3bfqG10.680499.90.4Contact Map0.686
3jwnH20.804199.90.435Contact Map0.666
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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