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OPENSEQ.org
UXAA - Altronate dehydratase
UniProt: P42604 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12734
Length: 495 (493)
Sequences: 690
Seq/Len: 1.40
UXAA
Paralog alert: 0.55 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GARD UXAA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
112_R 257_E 4.577 1.00
469_E 474_K 4.29 1.00
454_K 462_E 4.008 1.00
109_Q 252_P 3.822 1.00
314_D 317_T 3.234 1.00
255_L 468_V 3.225 1.00
279_L 413_S 3.024 1.00
445_F 463_F 2.889 1.00
65_A 69_I 2.824 1.00
51_K 68_D 2.809 1.00
294_V 407_C 2.781 1.00
315_E 319_E 2.743 1.00
112_R 253_G 2.695 1.00
48_D 71_A 2.666 1.00
283_S 293_T 2.648 1.00
319_E 323_T 2.621 1.00
278_M 463_F 2.589 1.00
391_A 405_A 2.543 1.00
140_I 234_G 2.53 1.00
50_A 53_A 2.529 1.00
446_D 452_H 2.461 1.00
19_L 34_L 2.452 1.00
433_S 437_A 2.396 1.00
112_R 251_E 2.343 0.99
55_V 80_T 2.302 0.99
48_D 70_A 2.271 0.99
190_G 245_M 2.229 0.99
34_L 44_F 2.191 0.99
111_Y 119_G 2.171 0.99
257_E 384_P 2.143 0.99
36_Q 73_V 2.132 0.99
49_I 53_A 2.095 0.98
50_A 68_D 2.018 0.98
454_K 459_L 1.952 0.97
253_G 257_E 1.943 0.97
313_R 372_V 1.937 0.97
320_K 373_D 1.919 0.97
449_Q 454_K 1.896 0.97
49_I 69_I 1.886 0.96
107_E 254_K 1.884 0.96
13_A 46_L 1.881 0.96
465_D 469_E 1.867 0.96
459_L 462_E 1.828 0.95
191_A 241_L 1.821 0.95
446_D 449_Q 1.82 0.95
51_K 67_A 1.779 0.95
330_Q 334_A 1.769 0.94
220_H 240_Q 1.7 0.93
292_T 387_N 1.695 0.92
45_A 69_I 1.678 0.92
286_V 291_G 1.649 0.91
436_A 446_D 1.625 0.90
47_T 53_A 1.621 0.90
466_T 474_K 1.601 0.89
450_L 456_M 1.599 0.89
449_Q 462_E 1.592 0.89
261_G 410_V 1.574 0.88
132_C 166_C 1.564 0.88
433_S 448_G 1.559 0.88
244_V 247_N 1.554 0.87
430_A 436_A 1.533 0.86
124_L 245_M 1.532 0.86
49_I 65_A 1.531 0.86
372_V 383_T 1.517 0.86
403_A 424_V 1.514 0.85
258_L 471_A 1.498 0.85
282_F 463_F 1.493 0.84
466_T 470_F 1.477 0.84
233_A 236_E 1.476 0.83
434_E 437_A 1.464 0.83
176_T 488_I 1.462 0.83
153_G 246_R 1.457 0.82
70_A 73_V 1.456 0.82
430_A 443_I 1.456 0.82
166_C 199_C 1.451 0.82
107_E 252_P 1.451 0.82
278_M 450_L 1.447 0.82
411_L 429_I 1.443 0.82
304_A 363_T 1.441 0.81
5_K 28_D 1.434 0.81
128_P 137_A 1.431 0.81
118_V 253_G 1.427 0.81
132_C 199_C 1.425 0.80
326_N 329_K 1.421 0.80
263_E 296_T 1.415 0.80
184_V 207_F 1.409 0.79
454_K 458_Q 1.407 0.79
64_Y 83_N 1.394 0.78
35_R 70_A 1.381 0.77
313_R 317_T 1.38 0.77
125_W 189_A 1.379 0.77
69_I 75_V 1.375 0.77
373_D 387_N 1.364 0.76
449_Q 459_L 1.356 0.76
436_A 443_I 1.354 0.75
144_F 235_I 1.354 0.75
321_L 388_L 1.354 0.75
433_S 446_D 1.347 0.75
106_R 465_D 1.343 0.75
312_C 321_L 1.34 0.74
285_Y 461_E 1.338 0.74
396_A 420_Y 1.323 0.73
121_R 479_E 1.319 0.73
477_C 480_R 1.318 0.73
445_F 466_T 1.316 0.72
281_R 457_P 1.316 0.72
109_Q 474_K 1.302 0.71
313_R 370_V 1.301 0.71
282_F 286_V 1.288 0.70
11_N 47_T 1.285 0.70
409_M 467_I 1.279 0.69
281_R 456_M 1.277 0.69
140_I 231_I 1.272 0.69
304_A 360_L 1.271 0.69
251_E 257_E 1.26 0.68
140_I 195_I 1.256 0.67
278_M 445_F 1.255 0.67
48_D 68_D 1.252 0.67
120_V 408_H 1.245 0.66
427_V 470_F 1.243 0.66
34_L 38_V 1.238 0.66
373_D 379_E 1.236 0.66
447_A 459_L 1.235 0.65
35_R 73_V 1.231 0.65
434_E 438_K 1.23 0.65
14_V 57_K 1.228 0.65
344_S 355_L 1.225 0.65
167_S 394_N 1.223 0.64
167_S 201_N 1.216 0.64
21_E 37_D 1.211 0.63
313_R 383_T 1.209 0.63
55_V 65_A 1.199 0.62
312_C 317_T 1.195 0.62
60_L 307_L 1.195 0.62
455_A 458_Q 1.192 0.61
124_L 238_L 1.186 0.61
260_F 467_I 1.171 0.59
137_A 195_I 1.169 0.59
279_L 411_L 1.15 0.57
11_N 49_I 1.141 0.56
304_A 343_P 1.133 0.56
20_A 37_D 1.13 0.55
429_I 447_A 1.128 0.55
76_H 353_T 1.124 0.55
433_S 457_P 1.124 0.55
282_F 411_L 1.119 0.54
466_T 469_E 1.117 0.54
19_L 50_A 1.117 0.54
260_F 409_M 1.116 0.54
461_E 465_D 1.112 0.54
278_M 460_L 1.108 0.53
24_E 33_T 1.107 0.53
180_L 467_I 1.101 0.52
259_K 407_C 1.101 0.52
328_F 394_N 1.1 0.52
339_I 355_L 1.099 0.52
373_D 382_K 1.097 0.52
242_Y 246_R 1.094 0.52
167_S 344_S 1.09 0.51
329_K 339_I 1.083 0.51
33_T 71_A 1.079 0.50
315_E 318_F 1.076 0.50
350_G 416_R 1.075 0.50
487_A 494_T 1.075 0.50
288_A 369_S 1.072 0.49
318_F 355_L 1.069 0.49
8_A 49_I 1.069 0.49
106_R 468_V 1.067 0.49
330_Q 333_I 1.066 0.49
106_R 255_L 1.061 0.48
120_V 471_A 1.061 0.48
222_M 226_Q 1.059 0.48
108_V 472_N 1.058 0.48
132_C 197_L 1.056 0.48
145_L 156_G 1.055 0.48
166_C 197_L 1.052 0.47
21_E 50_A 1.046 0.47
24_E 32_V 1.046 0.47
117_D 380_R 1.044 0.47
184_V 219_V 1.042 0.46
289_N 464_I 1.038 0.46
352_I 445_F 1.038 0.46
285_Y 460_L 1.034 0.46
375_L 387_N 1.034 0.46
294_V 381_L 1.033 0.46
120_V 472_N 1.032 0.45
316_A 468_V 1.031 0.45
302_F 329_K 1.029 0.45
20_A 34_L 1.027 0.45
205_A 222_M 1.026 0.45
263_E 399_T 1.022 0.44
67_A 249_K 1.021 0.44
263_E 402_L 1.02 0.44
319_E 326_N 1.019 0.44
285_Y 464_I 1.019 0.44
15_A 19_L 1.017 0.44
476_T 479_E 1.014 0.44
143_R 235_I 1.013 0.44
431_T 450_L 1.012 0.43
177_R 366_A 1.012 0.43
19_L 44_F 1.012 0.43
167_S 345_P 1.012 0.43
11_N 56_I 1.012 0.43
407_C 423_F 1.011 0.43
55_V 69_I 1.01 0.43
80_T 353_T 1.009 0.43
266_G 395_D 1.008 0.43
45_A 49_I 1.007 0.43
167_S 362_C 1.003 0.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3k3sA80.16971000.845Contact Map0.854
3lazA20.16571000.859Contact Map0.823
1opsA10.127375.90.979Contact Map0.47
1ucsA10.1273750.979Contact Map0.527
3teeA10.2808730.979Contact Map0.209
1msiA10.139469.60.98Contact Map0.527
3g8rA20.175867.20.98Contact Map0.201
1wvoA10.145564.20.98Contact Map0.277
1vliA10.179863.30.981Contact Map0.203
3frnA10.208160.50.981Contact Map0.218
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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