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OPENSEQ.org
TTDT - L-tartrate/succinate antiporter
UniProt: P39414 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12393
Length: 487 (456)
Sequences: 3550
Seq/Len: 7.79
TTDT
Paralog alert: 0.71 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: ARSB CITT TTDT YBHI YBIR YFJV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
118_K 330_D 4.012 1.00
136_R 139_F 3.565 1.00
361_S 365_K 3.519 1.00
275_E 278_A 3.418 1.00
78_Q 81_Q 3.22 1.00
296_A 316_V 2.975 1.00
81_Q 356_N 2.8 1.00
115_G 320_M 2.515 1.00
455_P 458_D 2.503 1.00
194_M 448_Y 2.482 1.00
195_W 199_V 2.374 1.00
209_L 219_I 2.293 1.00
231_S 234_D 2.209 1.00
148_E 166_I 2.165 1.00
112_F 296_A 2.104 1.00
43_V 61_G 2.094 1.00
327_S 330_D 2.083 1.00
457_A 461_R 2.078 1.00
236_F 240_L 2.059 1.00
128_I 131_K 2.04 1.00
150_I 154_V 2.022 1.00
302_F 306_Y 2.019 1.00
39_V 64_I 1.994 1.00
287_K 291_G 1.988 1.00
244_I 248_L 1.969 1.00
292_L 319_L 1.926 1.00
468_L 472_V 1.917 1.00
142_Y 251_P 1.911 1.00
115_G 289_M 1.9 1.00
111_M 317_V 1.893 1.00
128_I 132_K 1.881 1.00
107_F 341_F 1.877 1.00
270_R 274_T 1.85 1.00
37_F 359_F 1.81 1.00
274_T 278_A 1.791 1.00
34_W 38_A 1.79 1.00
144_V 170_I 1.779 1.00
292_L 316_V 1.768 1.00
298_V 302_F 1.753 1.00
256_V 259_P 1.736 1.00
393_F 467_G 1.725 1.00
98_F 345_A 1.694 1.00
39_V 65_I 1.691 1.00
42_G 46_G 1.688 1.00
107_F 111_M 1.681 1.00
249_L 473_L 1.661 1.00
233_G 237_L 1.653 1.00
210_T 232_W 1.648 1.00
191_S 458_D 1.644 1.00
157_S 161_R 1.636 1.00
291_G 295_G 1.636 1.00
295_G 299_L 1.633 1.00
329_D 334_N 1.604 1.00
439_P 449_Y 1.594 1.00
46_G 49_L 1.582 1.00
458_D 461_R 1.581 1.00
354_L 359_F 1.579 1.00
223_K 229_T 1.577 1.00
460_W 464_A 1.571 1.00
145_M 200_A 1.566 1.00
65_I 353_G 1.559 1.00
242_L 473_L 1.559 1.00
375_S 378_M 1.558 1.00
33_T 359_F 1.549 1.00
152_A 204_T 1.533 1.00
292_L 320_M 1.526 1.00
39_V 61_G 1.511 1.00
362_W 366_L 1.5 0.99
288_R 323_L 1.49 0.99
479_L 483_P 1.484 0.99
389_L 467_G 1.479 0.99
198_I 448_Y 1.477 0.99
108_A 313_G 1.474 0.99
299_L 315_S 1.471 0.99
31_N 35_L 1.469 0.99
149_L 243_S 1.465 0.99
45_V 49_L 1.456 0.99
207_I 240_L 1.446 0.99
290_L 294_V 1.436 0.99
234_D 237_L 1.423 0.99
133_M 143_A 1.416 0.99
274_T 277_Q 1.414 0.99
237_L 241_P 1.407 0.99
131_K 273_E 1.406 0.99
42_G 64_I 1.405 0.99
53_P 57_V 1.404 0.99
52_V 56_V 1.399 0.99
252_W 256_V 1.395 0.99
207_I 243_S 1.393 0.99
408_M 427_V 1.386 0.99
18_A 22_L 1.373 0.99
114_T 117_E 1.368 0.99
457_A 460_W 1.367 0.99
295_G 319_L 1.366 0.99
214_P 442_T 1.362 0.99
204_T 211_A 1.36 0.99
33_T 362_W 1.354 0.99
170_I 197_G 1.353 0.99
302_F 305_D 1.351 0.99
62_I 95_V 1.347 0.99
366_L 370_S 1.33 0.98
63_S 318_A 1.329 0.98
46_G 57_V 1.32 0.98
376_P 380_M 1.312 0.98
35_L 76_P 1.302 0.98
374_Y 378_M 1.299 0.98
119_T 289_M 1.294 0.98
39_V 43_V 1.293 0.98
246_L 470_F 1.289 0.98
401_T 431_I 1.286 0.98
426_M 478_G 1.284 0.98
138_L 255_Y 1.284 0.98
234_D 421_P 1.282 0.98
108_A 317_V 1.277 0.98
357_T 406_P 1.272 0.98
43_V 57_V 1.271 0.98
134_G 139_F 1.265 0.98
284_S 288_R 1.258 0.98
464_A 468_L 1.246 0.97
241_P 244_I 1.245 0.97
124_R 127_L 1.238 0.97
213_A 398_T 1.237 0.97
366_L 369_G 1.235 0.97
124_R 286_E 1.23 0.97
267_Q 270_R 1.229 0.97
354_L 360_I 1.222 0.97
203_V 246_L 1.222 0.97
205_S 211_A 1.221 0.97
249_L 469_I 1.216 0.97
72_L 82_P 1.207 0.97
253_L 469_I 1.2 0.97
365_K 368_A 1.197 0.96
36_Y 65_I 1.197 0.96
106_I 398_T 1.186 0.96
365_K 369_G 1.186 0.96
203_V 250_V 1.185 0.96
102_V 106_I 1.183 0.96
55_A 339_N 1.176 0.96
386_V 471_L 1.164 0.96
294_V 298_V 1.163 0.96
214_P 398_T 1.161 0.96
252_W 255_Y 1.159 0.96
46_G 60_V 1.155 0.95
153_P 207_I 1.155 0.95
409_I 413_L 1.153 0.95
103_I 341_F 1.152 0.95
208_F 211_A 1.151 0.95
214_P 432_G 1.144 0.95
299_L 312_V 1.139 0.95
158_N 161_R 1.136 0.95
235_W 428_G 1.13 0.95
398_T 442_T 1.126 0.95
205_S 208_F 1.126 0.95
22_L 25_V 1.126 0.95
344_L 398_T 1.122 0.94
391_R 400_Y 1.122 0.94
410_A 413_L 1.119 0.94
148_E 201_D 1.118 0.94
105_L 158_N 1.117 0.94
47_L 347_L 1.112 0.94
124_R 128_I 1.102 0.94
12_A 16_V 1.101 0.94
204_T 208_F 1.101 0.94
59_M 342_F 1.101 0.94
16_V 45_V 1.1 0.94
20_I 41_T 1.1 0.94
35_L 74_F 1.096 0.93
320_M 324_R 1.094 0.93
288_R 325_I 1.094 0.93
329_D 332_V 1.093 0.93
157_S 160_A 1.092 0.93
62_I 346_S 1.092 0.93
30_E 33_T 1.088 0.93
392_Y 397_A 1.087 0.93
159_S 212_M 1.084 0.93
355_N 361_S 1.078 0.93
138_L 251_P 1.069 0.92
346_S 350_L 1.065 0.92
458_D 462_L 1.06 0.92
198_I 444_P 1.058 0.92
292_L 323_L 1.058 0.92
14_L 18_A 1.056 0.92
205_S 212_M 1.055 0.92
309_A 313_G 1.052 0.92
126_A 173_L 1.052 0.92
214_P 401_T 1.044 0.91
147_S 166_I 1.044 0.91
54_G 58_A 1.042 0.91
300_W 313_G 1.041 0.91
36_Y 353_G 1.04 0.91
123_R 127_L 1.039 0.91
40_F 354_L 1.036 0.91
249_L 253_L 1.032 0.91
160_A 235_W 1.032 0.91
64_I 74_F 1.03 0.90
16_V 19_I 1.03 0.90
413_L 420_L 1.027 0.90
63_S 315_S 1.021 0.90
14_L 17_I 1.019 0.90
47_L 58_A 1.019 0.90
41_T 45_V 1.018 0.90
152_A 205_S 1.014 0.89
114_T 335_K 1.014 0.89
17_I 21_A 1.014 0.89
213_A 442_T 1.012 0.89
167_Y 447_I 1.009 0.89
124_R 280_G 1.008 0.89
282_L 290_L 1.007 0.89
19_I 23_L 1.005 0.89
398_T 443_G 1.003 0.89
289_M 293_M 1.002 0.89
412_A 423_F 1.001 0.89
181_P 453_Y 1 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.89731000.429Contact Map0.694
2rddB10.073960.976Contact Map0.322
2ksfA10.21774.90.977Contact Map0.134
4j72A20.48872.90.979Contact Map0.385
1pi7A10.07392.20.981Contact Map0.756
2gfpA20.188920.981Contact Map0.518
1ldfA10.50120.981Contact Map0.269
2kncA10.10681.90.981Contact Map0.518
4dveA30.32441.70.982Contact Map0.361
3ar4A10.12531.40.982Contact Map0.735
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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