May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
SGCX - Putative aminopeptidase SgcX
UniProt: P39366 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12557
Length: 373 (358)
Sequences: 1833
Seq/Len: 5.12
SGCX
Paralog alert: 0.67 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: FRVX SGCX YPDE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
30_L 34_R 3.265 1.00
26_A 68_M 3.123 1.00
146_K 150_I 3.012 1.00
342_D 345_R 2.782 1.00
15_H 28_V 2.778 1.00
30_L 48_V 2.708 1.00
290_H 349_A 2.707 1.00
190_G 193_D 2.657 1.00
192_A 206_L 2.575 1.00
31_C 34_R 2.506 1.00
220_V 308_Y 2.484 1.00
284_E 288_L 2.444 1.00
52_Y 192_A 2.401 1.00
51_R 205_Y 2.347 1.00
86_F 139_I 2.333 1.00
289_E 349_A 2.273 1.00
252_R 255_Q 2.259 1.00
61_R 205_Y 2.249 1.00
51_R 203_A 2.236 1.00
289_E 352_G 2.196 1.00
285_Q 289_E 2.175 1.00
265_H 268_G 2.157 1.00
105_T 161_T 2.119 1.00
10_F 14_Q 2.109 1.00
173_L 336_S 2.106 1.00
279_L 319_A 2.073 1.00
191_V 347_L 2.072 1.00
17_A 25_V 2.013 1.00
33_F 50_A 2 1.00
13_L 176_S 1.981 1.00
11_S 28_V 1.971 1.00
79_E 85_R 1.956 1.00
61_R 203_A 1.953 1.00
29_M 185_C 1.919 1.00
84_L 104_L 1.898 1.00
11_S 32_E 1.892 1.00
233_G 306_T 1.879 1.00
84_L 160_V 1.869 1.00
141_I 154_I 1.859 1.00
193_D 197_T 1.856 1.00
62_L 350_L 1.812 1.00
19_S 89_V 1.803 1.00
103_T 162_L 1.789 1.00
18_I 89_V 1.786 1.00
250_E 264_Y 1.776 1.00
40_V 48_V 1.775 1.00
341_T 345_R 1.764 1.00
70_E 177_K 1.762 1.00
45_L 221_P 1.705 1.00
10_F 13_L 1.646 0.99
54_S 203_A 1.642 0.99
113_G 139_I 1.619 0.99
143_A 149_A 1.607 0.99
33_F 189_L 1.596 0.99
335_A 340_L 1.581 0.99
293_P 342_D 1.579 0.99
158_T 339_D 1.563 0.99
143_A 152_M 1.556 0.99
23_N 46_G 1.516 0.99
65_F 209_S 1.514 0.99
75_V 160_V 1.513 0.99
15_H 24_A 1.505 0.99
53_G 203_A 1.498 0.99
64_I 350_L 1.491 0.99
194_A 348_T 1.485 0.98
283_L 319_A 1.467 0.98
42_R 48_V 1.465 0.98
141_I 149_A 1.455 0.98
204_V 350_L 1.422 0.98
155_Q 158_T 1.415 0.98
191_V 348_T 1.401 0.98
17_A 182_R 1.399 0.97
292_I 346_L 1.396 0.97
336_S 339_D 1.396 0.97
257_V 342_D 1.395 0.97
43_D 47_N 1.389 0.97
56_K 59_A 1.388 0.97
272_G 275_T 1.386 0.97
234_I 347_L 1.383 0.97
288_L 293_P 1.381 0.97
46_G 68_M 1.381 0.97
284_E 296_R 1.38 0.97
172_D 338_R 1.379 0.97
4_S 193_D 1.378 0.97
63_M 309_I 1.369 0.97
38_K 52_Y 1.368 0.97
153_G 156_V 1.366 0.97
16_N 100_S 1.36 0.97
66_A 188_L 1.338 0.96
186_T 190_G 1.33 0.96
212_E 329_H 1.323 0.96
36_Q 192_A 1.309 0.96
145_D 148_D 1.294 0.96
80_P 146_K 1.294 0.96
255_Q 270_L 1.293 0.95
61_R 229_D 1.287 0.95
63_M 226_V 1.286 0.95
256_G 268_G 1.284 0.95
63_M 222_V 1.283 0.95
39_E 53_G 1.28 0.95
47_N 221_P 1.279 0.95
159_P 338_R 1.274 0.95
227_K 313_Q 1.274 0.95
6_Q 337_L 1.272 0.95
277_P 281_R 1.27 0.95
194_A 345_R 1.264 0.95
38_K 192_A 1.264 0.95
36_Q 196_S 1.264 0.95
126_D 129_T 1.254 0.94
286_T 290_H 1.25 0.94
281_R 284_E 1.247 0.94
7_E 11_S 1.244 0.94
65_F 305_E 1.226 0.93
183_L 340_L 1.225 0.93
5_V 190_G 1.225 0.93
112_M 167_Q 1.221 0.93
92_P 162_L 1.208 0.93
288_L 291_N 1.208 0.93
30_L 42_R 1.206 0.93
348_T 351_A 1.205 0.93
187_A 340_L 1.204 0.93
147_D 151_R 1.198 0.92
110_P 145_D 1.197 0.92
326_R 339_D 1.193 0.92
325_C 328_T 1.185 0.92
27_D 31_C 1.181 0.92
29_M 189_L 1.179 0.92
29_M 208_A 1.176 0.92
246_H 307_G 1.171 0.91
26_A 48_V 1.168 0.91
68_M 185_C 1.155 0.91
8_T 32_E 1.152 0.90
79_E 83_F 1.148 0.90
88_R 94_Q 1.146 0.90
282_M 286_T 1.142 0.90
86_F 160_V 1.14 0.90
224_R 313_Q 1.129 0.89
285_Q 288_L 1.128 0.89
228_P 316_I 1.125 0.89
239_S 339_D 1.12 0.89
86_F 137_L 1.114 0.88
237_T 322_S 1.113 0.88
191_V 350_L 1.112 0.88
11_S 31_C 1.112 0.88
106_G 109_G 1.112 0.88
213_E 329_H 1.109 0.88
104_L 160_V 1.106 0.88
39_E 51_R 1.105 0.88
261_C 296_R 1.101 0.88
308_Y 314_D 1.1 0.87
254_N 336_S 1.099 0.87
288_L 294_V 1.098 0.87
63_M 207_V 1.092 0.87
190_G 340_L 1.09 0.87
137_L 331_P 1.087 0.87
147_D 150_I 1.08 0.86
158_T 338_R 1.074 0.86
62_L 230_L 1.069 0.85
158_T 336_S 1.062 0.85
198_M 351_A 1.059 0.85
32_E 35_R 1.058 0.85
41_W 49_V 1.056 0.84
56_K 201_D 1.056 0.84
289_E 351_A 1.055 0.84
102_V 139_I 1.051 0.84
185_C 208_A 1.05 0.84
155_Q 326_R 1.044 0.83
37_A 50_A 1.043 0.83
86_F 115_I 1.043 0.83
259_I 280_I 1.039 0.83
194_A 199_E 1.034 0.83
287_A 346_L 1.031 0.82
180_D 329_H 1.03 0.82
259_I 294_V 1.03 0.82
188_L 206_L 1.029 0.82
36_Q 193_D 1.029 0.82
180_D 212_E 1.023 0.82
284_E 294_V 1.023 0.82
286_T 352_G 1.017 0.81
74_M 87_E 1.012 0.81
345_R 349_A 1.012 0.81
323_I 335_A 1.012 0.81
186_T 340_L 1.008 0.80
23_N 42_R 1.008 0.80
104_L 139_I 1.005 0.80
282_M 352_G 1.005 0.80
6_Q 161_T 1.004 0.80
31_C 35_R 1.003 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ijzA120.91151000.4Contact Map0.228
1y0yA10.92491000.402Contact Map0.769
2vpuA10.91961000.412Contact Map0.723
2wyrA120.88471000.419Contact Map0.797
2fvgA10.90351000.439Contact Map0.723
3vatA10.9411000.439Contact Map0.453
2gljA240.91961000.448Contact Map0.416
1vheA10.97321000.449Contact Map0.761
3isxA10.89281000.455Contact Map0.645
2glfA40.91691000.459Contact Map0.547
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 2.6403 seconds.