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OPENSEQ.org
IDNT - Gnt-II system L-idonate transporter
UniProt: P39344 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12539
Length: 439 (438)
Sequences: 1312
Seq/Len: 3.00
IDNT
Paralog alert: 0.66 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DSDX GNTP GNTT GNTU IDNT YGBN YJHF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
15_I 20_F 3.468 1.00
231_I 272_I 3.268 1.00
49_S 318_D 3.038 1.00
87_T 222_F 2.967 1.00
9_G 35_V 2.944 1.00
167_F 383_T 2.942 1.00
222_F 226_I 2.935 1.00
314_Q 318_D 2.633 1.00
115_E 396_P 2.629 1.00
99_W 191_P 2.612 1.00
12_L 34_V 2.494 1.00
80_A 225_S 2.355 1.00
408_T 411_E 2.318 1.00
196_L 200_F 2.285 1.00
163_I 358_A 2.26 1.00
429_L 433_A 2.231 1.00
77_D 291_I 2.192 1.00
341_W 424_S 2.123 1.00
433_A 437_V 2.085 1.00
188_V 426_M 2.08 1.00
349_I 390_A 2.002 1.00
345_A 389_I 1.97 1.00
385_A 427_G 1.959 1.00
115_E 306_I 1.945 1.00
9_G 312_F 1.915 0.99
323_H 327_H 1.891 0.99
425_I 429_L 1.845 0.99
306_I 396_P 1.826 0.99
31_V 124_L 1.798 0.99
50_I 311_A 1.772 0.99
338_L 428_L 1.768 0.99
391_S 395_D 1.755 0.99
390_A 417_T 1.755 0.99
70_M 292_I 1.731 0.99
58_L 307_A 1.73 0.99
114_F 397_G 1.729 0.99
52_N 56_S 1.712 0.98
166_I 362_A 1.693 0.98
221_S 224_N 1.693 0.98
11_A 15_I 1.68 0.98
418_V 422_L 1.678 0.98
251_T 255_F 1.615 0.98
152_C 388_V 1.611 0.97
36_G 315_V 1.574 0.97
193_F 418_V 1.561 0.97
275_F 280_R 1.543 0.96
271_V 275_F 1.542 0.96
35_V 312_F 1.538 0.96
349_I 389_I 1.5 0.96
74_L 273_A 1.498 0.96
26_I 270_I 1.474 0.95
327_H 330_T 1.463 0.95
174_T 380_V 1.461 0.95
373_H 376_P 1.431 0.94
145_A 190_G 1.42 0.94
118_F 404_Y 1.419 0.94
94_K 131_S 1.408 0.93
389_I 424_S 1.407 0.93
148_S 420_E 1.406 0.93
402_K 412_T 1.401 0.93
223_W 227_F 1.399 0.93
180_I 184_P 1.397 0.93
150_T 157_H 1.385 0.93
54_I 62_A 1.381 0.92
15_I 19_G 1.379 0.92
369_I 379_M 1.37 0.92
410_G 414_R 1.363 0.92
188_V 192_L 1.346 0.91
140_G 405_F 1.345 0.91
412_T 416_W 1.345 0.91
169_A 174_T 1.339 0.91
90_A 199_R 1.333 0.91
341_W 428_L 1.33 0.90
181_I 383_T 1.32 0.90
117_G 147_L 1.31 0.90
53_G 314_Q 1.308 0.89
16_L 22_V 1.303 0.89
366_L 370_N 1.303 0.89
109_G 157_H 1.299 0.89
197_L 200_F 1.294 0.89
93_G 96_R 1.29 0.89
73_K 77_D 1.286 0.88
37_F 43_A 1.28 0.88
45_A 48_H 1.279 0.88
181_I 434_I 1.279 0.88
23_N 26_I 1.279 0.88
348_R 395_D 1.275 0.88
28_L 312_F 1.268 0.87
143_M 146_A 1.266 0.87
51_Q 60_G 1.265 0.87
105_G 117_G 1.261 0.87
42_D 45_A 1.256 0.87
14_L 18_I 1.251 0.86
114_F 401_F 1.246 0.86
63_M 263_A 1.244 0.86
325_I 350_A 1.244 0.86
299_I 303_V 1.243 0.86
389_I 421_T 1.237 0.86
433_A 436_A 1.21 0.84
102_V 186_V 1.21 0.84
9_G 34_V 1.208 0.84
70_M 270_I 1.207 0.84
86_T 131_S 1.204 0.83
177_Y 381_L 1.2 0.83
63_M 67_F 1.196 0.83
148_S 388_V 1.185 0.82
220_P 225_S 1.183 0.82
150_T 160_P 1.181 0.82
417_T 424_S 1.18 0.82
31_V 34_V 1.177 0.82
224_N 276_T 1.176 0.81
284_T 287_Q 1.172 0.81
17_M 24_G 1.167 0.81
272_I 276_T 1.164 0.81
112_M 144_V 1.161 0.80
99_W 103_I 1.157 0.80
151_H 157_H 1.155 0.80
308_G 311_A 1.15 0.79
434_I 437_V 1.149 0.79
381_L 431_V 1.149 0.79
169_A 380_V 1.143 0.79
252_V 433_A 1.143 0.79
192_L 199_R 1.137 0.78
22_V 27_A 1.134 0.78
22_V 271_V 1.129 0.78
37_F 268_I 1.129 0.78
108_V 121_L 1.129 0.78
334_L 342_T 1.128 0.78
235_L 268_I 1.128 0.78
141_V 193_F 1.126 0.77
49_S 314_Q 1.126 0.77
12_L 16_L 1.123 0.77
49_S 316_L 1.121 0.77
248_K 253_R 1.119 0.77
148_S 354_A 1.118 0.77
313_K 317_V 1.118 0.77
14_L 31_V 1.118 0.77
12_L 31_V 1.113 0.76
5_I 38_A 1.11 0.76
159_G 309_G 1.108 0.76
66_G 304_F 1.106 0.76
314_Q 317_V 1.099 0.75
243_E 437_V 1.099 0.75
176_L 180_I 1.098 0.75
84_I 225_S 1.097 0.75
34_V 38_A 1.093 0.74
9_G 39_E 1.091 0.74
181_I 430_G 1.086 0.74
33_A 264_V 1.081 0.73
431_V 435_N 1.081 0.73
390_A 413_L 1.08 0.73
149_V 423_I 1.078 0.73
340_C 381_L 1.077 0.73
36_G 46_V 1.068 0.72
337_L 379_M 1.065 0.72
193_F 197_L 1.064 0.72
216_E 219_M 1.062 0.71
54_I 63_M 1.061 0.71
177_Y 438_L 1.059 0.71
98_Q 138_Y 1.059 0.71
28_L 309_G 1.057 0.71
145_A 419_M 1.056 0.71
83_R 87_T 1.055 0.71
393_V 404_Y 1.054 0.71
251_T 437_V 1.052 0.70
163_I 169_A 1.051 0.70
172_G 316_L 1.05 0.70
151_H 155_P 1.049 0.70
15_I 74_L 1.047 0.70
87_T 91_T 1.045 0.70
47_L 264_V 1.045 0.70
151_H 355_T 1.042 0.69
83_R 222_F 1.042 0.69
364_V 382_A 1.041 0.69
325_I 408_T 1.038 0.69
160_P 427_G 1.036 0.69
93_G 100_A 1.035 0.69
413_L 417_T 1.031 0.68
192_L 196_L 1.029 0.68
91_T 95_K 1.025 0.67
48_H 91_T 1.023 0.67
30_L 180_I 1.023 0.67
193_F 196_L 1.023 0.67
391_S 416_W 1.022 0.67
238_I 247_P 1.021 0.67
248_K 251_T 1.019 0.67
176_L 179_F 1.018 0.67
60_G 396_P 1.017 0.67
348_R 357_A 1.017 0.67
71_L 270_I 1.017 0.67
274_I 304_F 1.015 0.66
268_I 272_I 1.014 0.66
67_F 266_L 1.009 0.66
141_V 145_A 1.006 0.65
221_S 225_S 1.006 0.65
181_I 431_V 1.005 0.65
218_E 281_N 1.004 0.65
153_F 427_G 1.002 0.65
260_G 309_G 1.001 0.65
348_R 354_A 1.001 0.65
82_Q 217_E 1 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.92031000.747Contact Map0.359
3qnqA40.4533640.964Contact Map0.276
3giaA10.432815.30.974Contact Map0.231
3ne5A10.3447.80.977Contact Map0.212
4dx5A30.38727.50.978Contact Map0.31
3aqpA20.35315.50.979Contact Map0.365
4b19A10.06834.50.98Contact Map0.107
2kluA10.14584.20.98Contact Map0.354
4k0jA60.37133.70.981Contact Map0.287
1m56D20.11393.30.981Contact Map0.354
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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