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OPENSEQ.org
EPMB - L-lysine 2,3-aminomutase
UniProt: P39280 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12473
Length: 342 (326)
Sequences: 879
Seq/Len: 2.70
EPMB
Paralog alert: 0.08 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
152_A 181_Q 3.441 1.00
207_E 242_K 3.307 1.00
195_S 222_L 3.232 1.00
64_E 67_N 3.161 1.00
176_D 180_T 2.767 1.00
264_A 309_E 2.553 1.00
214_A 245_R 2.508 1.00
23_V 60_I 2.49 1.00
240_M 279_V 2.43 1.00
302_E 305_Q 2.358 1.00
112_A 157_L 2.35 1.00
229_A 266_T 2.334 1.00
145_Q 149_E 2.171 1.00
60_I 63_M 2.114 1.00
149_E 153_A 2.065 1.00
244_R 250_L 2.031 1.00
126_Y 227_N 1.969 0.99
176_D 216_S 1.936 0.99
224_N 252_N 1.922 0.99
70_D 230_N 1.909 0.99
263_N 266_T 1.895 0.99
172_D 206_T 1.886 0.99
25_D 28_E 1.883 0.99
112_A 160_M 1.841 0.99
63_M 70_D 1.825 0.99
244_R 278_G 1.774 0.99
75_Q 196_R 1.763 0.98
30_L 41_L 1.747 0.98
168_L 222_L 1.744 0.98
113_L 163_S 1.733 0.98
18_Q 203_A 1.725 0.98
152_A 184_A 1.702 0.98
238_Q 241_A 1.689 0.98
189_K 276_D 1.674 0.98
106_H 150_Y 1.648 0.97
240_M 277_A 1.645 0.97
176_D 212_C 1.617 0.97
180_T 216_S 1.584 0.96
238_Q 242_K 1.583 0.96
73_L 77_L 1.58 0.96
206_T 210_V 1.574 0.96
262_D 302_E 1.566 0.96
59_F 76_V 1.556 0.96
82_E 125_R 1.535 0.95
27_D 45_R 1.52 0.95
267_L 271_S 1.513 0.95
289_K 297_M 1.512 0.95
157_L 160_M 1.5 0.95
268_A 313_L 1.499 0.95
224_N 240_M 1.472 0.94
232_V 277_A 1.468 0.94
148_L 152_A 1.458 0.94
151_V 185_I 1.458 0.94
58_S 233_D 1.442 0.93
145_Q 181_Q 1.441 0.93
62_R 233_D 1.437 0.93
223_V 251_L 1.401 0.92
64_E 230_N 1.392 0.91
199_I 226_I 1.383 0.91
267_L 284_L 1.38 0.91
183_E 191_L 1.344 0.89
154_H 157_L 1.343 0.89
287_L 298_V 1.336 0.89
221_L 249_T 1.326 0.89
145_Q 177_W 1.308 0.88
116_V 170_A 1.308 0.88
264_A 306_I 1.307 0.88
258_R 262_D 1.298 0.87
32_L 60_I 1.296 0.87
205_I 243_L 1.276 0.86
175_L 212_C 1.274 0.86
176_D 215_R 1.268 0.85
214_A 246_V 1.266 0.85
194_H 285_H 1.266 0.85
229_A 263_N 1.258 0.85
190_R 219_Q 1.255 0.85
182_L 188_I 1.253 0.84
179_L 212_C 1.251 0.84
76_V 126_Y 1.249 0.84
290_V 293_A 1.246 0.84
273_A 276_D 1.242 0.84
116_V 178_L 1.237 0.83
26_P 41_L 1.237 0.83
237_R 277_A 1.236 0.83
155_P 186_P 1.234 0.83
275_F 318_L 1.232 0.83
14_D 17_T 1.227 0.83
207_E 211_E 1.223 0.82
237_R 273_A 1.222 0.82
151_V 188_I 1.214 0.82
159_E 194_H 1.214 0.82
172_D 204_R 1.207 0.81
121_A 197_L 1.197 0.81
158_D 189_K 1.195 0.80
157_L 188_I 1.194 0.80
300_D 324_R 1.187 0.80
213_F 248_V 1.178 0.79
168_L 195_S 1.177 0.79
58_S 62_R 1.173 0.79
175_L 193_I 1.168 0.78
126_Y 225_H 1.163 0.78
303_A 322_L 1.157 0.77
74_R 81_D 1.154 0.77
326_I 333_T 1.152 0.77
256_L 298_V 1.152 0.77
258_R 302_E 1.15 0.77
161_I 285_H 1.147 0.76
110_N 158_D 1.145 0.76
46_S 80_Q 1.144 0.76
286_V 299_S 1.144 0.76
254_S 271_S 1.139 0.76
161_I 194_H 1.136 0.75
243_L 248_V 1.136 0.75
300_D 335_L 1.131 0.75
14_D 18_Q 1.13 0.75
94_L 288_D 1.13 0.75
167_P 193_I 1.13 0.75
224_N 279_V 1.128 0.75
162_F 302_E 1.126 0.75
71_P 230_N 1.121 0.74
190_R 317_Y 1.118 0.74
74_R 79_S 1.117 0.74
96_E 131_H 1.117 0.74
196_R 227_N 1.113 0.73
76_V 122_V 1.11 0.73
57_R 61_D 1.108 0.73
69_D 74_R 1.1 0.72
49_K 195_S 1.1 0.72
158_D 272_N 1.096 0.72
199_I 224_N 1.096 0.72
211_E 260_V 1.094 0.72
106_H 112_A 1.094 0.72
42_L 186_P 1.093 0.71
188_I 220_I 1.091 0.71
234_E 238_Q 1.089 0.71
77_L 306_I 1.085 0.71
232_V 273_A 1.085 0.71
227_N 257_L 1.081 0.70
183_E 216_S 1.076 0.70
157_L 191_L 1.074 0.69
122_V 200_V 1.074 0.69
28_E 31_R 1.073 0.69
104_L 114_L 1.071 0.69
210_V 246_V 1.067 0.69
252_N 279_V 1.067 0.69
117_K 169_M 1.065 0.69
285_H 323_A 1.061 0.68
102_P 143_N 1.06 0.68
23_V 29_L 1.059 0.68
168_L 175_L 1.059 0.68
265_Q 269_N 1.057 0.68
304_R 335_L 1.055 0.68
141_K 174_E 1.053 0.67
163_S 288_D 1.053 0.67
307_M 311_L 1.048 0.67
146_T 149_E 1.045 0.66
22_V 54_R 1.045 0.66
75_Q 227_N 1.044 0.66
151_V 157_L 1.044 0.66
112_A 150_Y 1.038 0.66
207_E 234_E 1.034 0.65
123_N 134_Y 1.033 0.65
190_R 315_S 1.028 0.65
153_A 156_E 1.027 0.64
42_L 45_R 1.024 0.64
307_M 334_P 1.022 0.64
309_E 312_T 1.021 0.64
159_E 251_L 1.018 0.63
171_K 174_E 1.017 0.63
252_N 274_L 1.016 0.63
106_H 113_L 1.013 0.63
167_P 170_A 1.009 0.62
269_N 273_A 1.007 0.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2a5hA40.99421000.445Contact Map0.743
3rfaA20.871399.90.807Contact Map0.321
1tv8A20.663799.70.863Contact Map0.49
2qgqA80.666799.60.866Contact Map0.551
3c8fA10.637499.60.873Contact Map0.405
1oltA10.798299.50.879Contact Map0.422
3iixA10.766199.40.884Contact Map0.409
3t7vA10.801299.40.885Contact Map0.38
4jc0A20.932799.40.885Contact Map0.443
2yx0A10.815899.30.889Contact Map0.415
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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