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OPENSEQ.org
UXUR - Uxu operon transcriptional regulator
UniProt: P39161 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG20249
Length: 257 (228)
Sequences: 9390
Seq/Len: 41.18
UXUR
Paralog alert: 0.78 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: CSIR DGOR EXUR FADR GLCC LLDR MCBR NANR PDHR UXUR YDFH YIEP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
126_R 209_I 4.506 1.00
111_E 217_K 3.495 1.00
212_D 215_A 3.333 1.00
28_N 31_E 3.276 1.00
133_E 202_K 3.135 1.00
21_L 42_M 2.738 1.00
21_L 26_P 2.707 1.00
97_E 162_S 2.686 1.00
15_G 56_M 2.355 1.00
36_E 47_R 2.339 1.00
104_L 108_N 2.315 1.00
19_R 60_K 2.236 1.00
14_V 45_V 2.214 1.00
14_V 43_L 2.18 1.00
207_A 215_A 2.094 1.00
118_T 121_D 2.063 1.00
103_Q 225_E 2.048 1.00
115_L 213_A 2.021 1.00
121_D 160_H 1.988 1.00
140_A 143_S 1.969 1.00
124_K 154_A 1.909 1.00
122_I 209_I 1.9 1.00
215_A 219_A 1.89 1.00
65_V 71_I 1.825 1.00
100_Q 112_F 1.795 1.00
64_E 74_L 1.694 1.00
20_D 24_K 1.662 1.00
154_A 157_E 1.661 1.00
111_E 214_R 1.646 1.00
129_L 205_L 1.642 1.00
152_H 201_H 1.627 1.00
217_K 221_W 1.612 1.00
206_A 210_K 1.602 1.00
157_E 165_V 1.567 1.00
128_A 147_G 1.563 1.00
17_M 21_L 1.553 1.00
153_L 169_R 1.553 1.00
39_I 50_V 1.549 1.00
101_A 167_L 1.532 1.00
107_S 217_K 1.53 1.00
218_L 222_Q 1.492 1.00
200_D 223_H 1.438 1.00
111_E 213_A 1.429 1.00
110_A 114_A 1.429 1.00
66_R 69_A 1.428 1.00
110_A 220_M 1.427 1.00
210_K 215_A 1.427 1.00
97_E 163_M 1.426 1.00
202_K 206_A 1.422 1.00
15_G 60_K 1.396 0.99
131_L 150_Q 1.392 0.99
155_I 208_L 1.378 0.99
117_A 122_I 1.375 0.99
108_N 111_E 1.362 0.99
159_T 165_V 1.357 0.99
107_S 221_W 1.355 0.99
17_M 20_D 1.337 0.99
38_E 42_M 1.334 0.99
110_A 216_A 1.327 0.99
100_Q 116_Q 1.325 0.99
215_A 218_L 1.324 0.99
213_A 217_K 1.317 0.99
121_D 158_A 1.317 0.99
117_A 208_L 1.315 0.99
117_A 211_K 1.314 0.99
127_Q 131_L 1.301 0.99
8_Q 16_A 1.3 0.99
109_I 156_A 1.275 0.99
156_A 168_F 1.269 0.99
102_R 106_E 1.267 0.99
103_Q 107_S 1.265 0.99
166_E 170_Q 1.264 0.99
97_E 161_N 1.255 0.99
117_A 158_A 1.248 0.99
54_L 63_V 1.242 0.98
203_Q 219_A 1.236 0.98
200_D 226_N 1.235 0.98
119_R 211_K 1.233 0.98
131_L 147_G 1.23 0.98
103_Q 221_W 1.229 0.98
13_E 17_M 1.221 0.98
126_R 205_L 1.214 0.98
124_K 157_E 1.208 0.98
37_R 41_E 1.208 0.98
204_I 219_A 1.208 0.98
204_I 220_M 1.203 0.98
21_L 43_L 1.194 0.98
126_R 130_Q 1.194 0.98
66_R 72_Y 1.189 0.98
154_A 158_A 1.188 0.98
150_Q 154_A 1.188 0.98
17_M 43_L 1.186 0.98
148_D 152_H 1.177 0.98
100_Q 161_N 1.162 0.97
122_I 211_K 1.159 0.97
122_I 205_L 1.156 0.97
107_S 111_E 1.152 0.97
203_Q 215_A 1.148 0.97
58_E 63_V 1.148 0.97
205_L 209_I 1.141 0.97
63_V 71_I 1.133 0.97
117_A 121_D 1.13 0.97
203_Q 222_Q 1.129 0.97
58_E 65_V 1.123 0.97
151_F 205_L 1.118 0.96
201_H 223_H 1.109 0.96
22_I 73_V 1.106 0.96
207_A 212_D 1.099 0.96
130_Q 133_E 1.089 0.96
130_Q 134_R 1.089 0.96
103_Q 228_K 1.087 0.96
128_A 154_A 1.084 0.96
114_A 213_A 1.081 0.95
153_L 157_E 1.069 0.95
15_G 19_R 1.058 0.95
52_E 55_I 1.052 0.95
69_A 72_Y 1.052 0.95
32_R 72_Y 1.044 0.94
133_E 198_L 1.043 0.94
214_R 218_L 1.039 0.94
27_Y 73_V 1.038 0.94
129_L 202_K 1.033 0.94
125_M 154_A 1.031 0.94
152_H 223_H 1.026 0.94
19_R 62_L 1.025 0.93
114_A 216_A 1.024 0.93
96_F 228_K 1.022 0.93
46_T 49_V 1.017 0.93
221_W 225_E 1.015 0.93
93_A 97_E 1.014 0.93
146_S 150_Q 1.01 0.93
64_E 72_Y 1.008 0.93
165_V 169_R 1.003 0.93
45_V 50_V 1.002 0.92
124_K 127_Q 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3sxyA20.83271000.268Contact Map0.773
3ihuA20.83271000.271Contact Map0.658
3c7jA20.85211000.272Contact Map0.8
2hs5A10.8561000.279Contact Map0.602
2di3A20.89491000.29Contact Map0.665
1hw1A20.90661000.29Contact Map0.64
4hamA10.490399.90.578Contact Map0.705
3by6A50.478699.90.594Contact Map0.839
3ic7A20.470899.90.597Contact Map0.643
3neuA10.470899.80.615Contact Map0.673
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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