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OPENSEQ.org
DEGQ - Periplasmic pH-dependent serine endoprotease DegQ
UniProt: P39099 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12612
Length: 455 (428)
Sequences: 1746
Seq/Len: 4.08
DEGQ
Paralog alert: 0.51 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: DEGP DEGQ DEGS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
220_N 224_E 5.945 1.00
47_E 163_R 5.164 1.00
345_L 354_V 4.657 1.00
374_A 377_G 4.332 1.00
316_S 344_G 3.957 1.00
117_I 131_L 3.844 1.00
158_D 161_K 3.538 1.00
394_I 408_L 3.285 1.00
209_I 243_G 3.226 1.00
142_L 259_I 3.176 1.00
162_L 226_I 3.104 1.00
377_G 383_G 3.065 1.00
127_F 145_I 2.989 1.00
186_V 203_I 2.957 1.00
155_A 224_E 2.88 1.00
108_N 134_S 2.843 1.00
294_V 308_V 2.744 1.00
424_S 427_E 2.704 1.00
300_G 304_A 2.697 1.00
412_D 445_R 2.67 1.00
160_D 249_N 2.648 1.00
96_I 121_L 2.631 1.00
344_G 351_P 2.625 1.00
294_V 314_I 2.511 1.00
373_P 377_G 2.502 1.00
130_K 146_Q 2.478 1.00
105_L 251_A 2.464 1.00
158_D 249_N 2.446 1.00
342_K 353_E 2.408 1.00
103_Y 132_I 2.342 1.00
318_N 335_T 2.338 1.00
52_A 153_Q 2.329 1.00
417_V 428_M 2.298 1.00
43_A 163_R 2.265 1.00
105_L 255_A 2.241 1.00
95_V 225_L 2.221 1.00
308_V 343_L 2.13 1.00
217_A 225_L 2.118 1.00
41_S 166_D 2.116 1.00
340_K 355_E 2.081 1.00
104_V 145_I 2.072 1.00
308_V 345_L 2.055 1.00
317_L 332_I 2.038 1.00
97_I 255_A 2.032 1.00
374_A 383_G 2.011 1.00
345_L 352_L 2 1.00
317_L 335_T 1.981 1.00
95_V 217_A 1.961 1.00
315_T 346_L 1.958 1.00
103_Y 142_L 1.937 1.00
154_I 219_L 1.881 1.00
377_G 381_S 1.879 1.00
43_A 166_D 1.864 1.00
342_K 355_E 1.848 1.00
44_P 163_R 1.845 1.00
49_V 154_I 1.841 1.00
344_G 353_E 1.822 1.00
423_N 427_E 1.771 0.99
116_K 128_D 1.764 0.99
256_Q 260_D 1.739 0.99
162_L 186_V 1.707 0.99
374_A 378_A 1.699 0.99
340_K 357_T 1.693 0.99
444_V 447_N 1.682 0.99
129_A 143_L 1.674 0.99
378_A 383_G 1.666 0.99
269_L 356_V 1.642 0.99
52_A 154_I 1.633 0.99
316_S 321_P 1.589 0.99
374_A 379_T 1.585 0.99
445_R 450_I 1.571 0.98
316_S 319_G 1.568 0.98
59_E 116_K 1.565 0.98
118_S 126_E 1.555 0.98
207_A 243_G 1.544 0.98
186_V 226_I 1.544 0.98
374_A 381_S 1.537 0.98
167_F 183_S 1.536 0.98
234_A 237_G 1.529 0.98
299_P 304_A 1.513 0.98
103_Y 259_I 1.479 0.97
280_I 284_F 1.473 0.97
269_L 301_S 1.472 0.97
315_T 351_P 1.458 0.97
308_V 354_V 1.449 0.97
42_L 167_F 1.411 0.96
211_R 235_P 1.406 0.96
96_I 151_L 1.405 0.96
45_M 169_V 1.401 0.96
228_I 251_A 1.401 0.96
140_I 228_I 1.387 0.96
130_K 144_Q 1.387 0.96
205_T 218_L 1.382 0.96
71_E 76_F 1.377 0.96
71_E 79_D 1.365 0.95
315_T 344_G 1.362 0.95
290_R 321_P 1.352 0.95
105_L 248_S 1.345 0.95
156_I 248_S 1.339 0.95
377_G 380_L 1.339 0.95
275_E 325_F 1.314 0.94
422_V 427_E 1.313 0.94
46_L 181_A 1.311 0.94
58_V 91_L 1.303 0.94
373_P 378_A 1.299 0.93
159_S 249_N 1.295 0.93
380_L 383_G 1.29 0.93
49_V 171_V 1.287 0.93
70_E 73_K 1.286 0.93
95_V 219_L 1.282 0.93
265_K 360_T 1.275 0.93
154_I 225_L 1.264 0.92
123_D 127_F 1.258 0.92
74_K 78_D 1.256 0.92
317_L 343_L 1.254 0.92
272_K 296_E 1.254 0.92
55_S 90_G 1.253 0.92
427_E 430_K 1.233 0.91
305_K 359_D 1.23 0.91
301_S 304_A 1.226 0.90
112_N 136_D 1.225 0.90
373_P 383_G 1.222 0.90
173_N 231_A 1.221 0.90
306_A 356_V 1.214 0.90
392_I 422_V 1.203 0.89
181_A 185_I 1.187 0.88
177_L 180_T 1.186 0.88
235_P 240_V 1.179 0.88
104_V 143_L 1.178 0.88
49_V 219_L 1.174 0.88
261_F 265_K 1.173 0.88
312_D 347_R 1.17 0.88
379_T 383_G 1.165 0.87
309_K 352_L 1.163 0.87
274_T 295_S 1.16 0.87
276_M 286_L 1.159 0.87
420_D 431_V 1.156 0.87
200_E 231_A 1.146 0.86
309_K 348_N 1.146 0.86
73_K 77_G 1.145 0.86
271_I 292_A 1.142 0.86
56_V 117_I 1.142 0.86
156_I 252_R 1.139 0.86
318_N 339_T 1.136 0.85
196_L 231_A 1.13 0.85
252_R 256_Q 1.129 0.85
422_V 431_V 1.128 0.85
335_T 358_L 1.126 0.85
140_I 248_S 1.123 0.84
108_N 112_N 1.115 0.84
427_E 431_V 1.115 0.84
251_A 255_A 1.112 0.84
426_A 430_K 1.109 0.83
99_A 150_K 1.106 0.83
138_S 254_L 1.098 0.83
276_M 289_Q 1.095 0.82
382_D 392_I 1.095 0.82
96_I 145_I 1.093 0.82
56_V 119_I 1.086 0.82
95_V 154_I 1.083 0.81
336_E 339_T 1.076 0.81
376_E 383_G 1.072 0.81
267_G 358_L 1.071 0.80
265_K 358_L 1.069 0.80
100_S 103_Y 1.067 0.80
55_S 91_L 1.065 0.80
263_E 360_T 1.064 0.80
173_N 178_G 1.062 0.80
103_Y 144_Q 1.06 0.79
121_L 145_I 1.056 0.79
112_N 131_L 1.054 0.79
197_E 200_E 1.051 0.79
95_V 228_I 1.045 0.78
45_M 219_L 1.045 0.78
373_P 379_T 1.041 0.78
196_L 202_F 1.038 0.77
42_L 183_S 1.035 0.77
378_A 381_S 1.031 0.77
375_L 378_A 1.024 0.76
376_E 379_T 1.022 0.76
290_R 323_N 1.021 0.76
58_V 115_Q 1.021 0.76
54_V 104_V 1.02 0.76
168_A 226_I 1.019 0.76
142_L 255_A 1.008 0.75
74_K 77_G 1.006 0.74
51_P 152_T 1.004 0.74
415_I 444_V 1.002 0.74
394_I 412_D 1.002 0.74
379_T 396_E 1.002 0.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ky9A20.93411000.333Contact Map0.622
3pv2A40.95161000.358Contact Map0.787
4a8cA120.93851000.381Contact Map0.061
3stjA120.7561000.479Contact Map0.799
4flnA30.93191000.49Contact Map0.72
1lcyA10.68131000.548Contact Map0.728
4ic6A30.74951000.554Contact Map0.757
3qo6A30.72971000.557Contact Map0.808
1te0A20.69231000.567Contact Map0.714
3numA10.69891000.574Contact Map0.676
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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