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OPENSEQ.org
YFJD - UPF0053 inner membrane protein YfjD
UniProt: P37908 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12442
Length: 428 (412)
Sequences: 3287
Seq/Len: 7.98
YFJD
Paralog alert: 0.62 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: CORC YFJD YTFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
214_I 315_L 3.998 1.00
386_E 392_T 3.695 1.00
351_I 416_V 3.321 1.00
350_I 404_L 3.178 1.00
304_L 315_L 3.13 1.00
282_V 291_Q 3.08 1.00
393_R 402_D 2.798 1.00
380_I 414_V 2.664 1.00
240_L 276_A 2.646 1.00
216_G 241_Y 2.633 1.00
395_R 400_D 2.603 1.00
242_R 247_D 2.578 1.00
242_R 273_L 2.551 1.00
256_E 277_D 2.512 1.00
393_R 400_D 2.42 1.00
345_N 348_S 2.387 1.00
222_D 225_S 2.366 1.00
41_M 126_Y 2.302 1.00
221_D 225_S 2.279 1.00
103_F 149_I 2.241 1.00
286_T 294_K 2.192 1.00
38_L 52_V 2.125 1.00
120_Y 123_K 2.068 1.00
20_S 74_N 2.055 1.00
304_L 312_I 2.043 1.00
360_I 364_F 2.033 1.00
217_I 226_I 1.999 1.00
133_A 137_I 1.992 1.00
350_I 413_Q 1.959 1.00
214_I 312_I 1.957 1.00
144_W 148_A 1.948 1.00
152_M 156_M 1.942 1.00
216_G 245_L 1.942 1.00
37_R 122_E 1.924 1.00
331_T 334_S 1.912 1.00
400_D 417_F 1.851 1.00
271_T 274_R 1.839 1.00
344_Q 348_S 1.837 1.00
207_I 288_L 1.832 1.00
246_D 311_D 1.831 1.00
355_A 376_V 1.819 1.00
376_V 414_V 1.796 1.00
204_V 291_Q 1.791 1.00
251_M 279_I 1.789 1.00
45_G 49_A 1.774 1.00
402_D 417_F 1.766 1.00
178_V 193_L 1.76 1.00
355_A 360_I 1.735 1.00
20_S 70_N 1.724 1.00
381_L 411_I 1.711 1.00
236_G 253_R 1.696 1.00
343_P 349_V 1.689 1.00
42_A 53_E 1.688 1.00
319_E 323_E 1.687 1.00
220_N 242_R 1.673 1.00
51_R 130_F 1.673 1.00
228_R 232_H 1.673 1.00
51_R 133_A 1.669 1.00
405_D 413_Q 1.651 1.00
351_I 360_I 1.651 1.00
202_M 206_D 1.648 1.00
22_Y 131_L 1.614 1.00
405_D 412_K 1.605 1.00
192_M 196_V 1.604 1.00
380_I 401_I 1.599 1.00
237_R 301_K 1.587 1.00
379_V 396_I 1.579 1.00
61_R 140_M 1.577 1.00
396_I 401_I 1.57 1.00
291_Q 316_V 1.551 1.00
20_S 24_S 1.545 1.00
67_L 70_N 1.498 1.00
127_P 131_L 1.494 0.99
207_I 316_V 1.477 0.99
46_N 126_Y 1.473 0.99
407_Q 412_K 1.467 0.99
70_N 74_N 1.467 0.99
212_S 311_D 1.466 0.99
51_R 129_S 1.464 0.99
288_L 321_I 1.46 0.99
219_I 242_R 1.453 0.99
39_R 43_K 1.44 0.99
23_F 69_G 1.44 0.99
322_L 326_V 1.438 0.99
217_I 240_L 1.431 0.99
402_D 415_K 1.429 0.99
302_V 317_T 1.423 0.99
26_S 128_S 1.417 0.99
293_V 296_Q 1.417 0.99
192_M 325_I 1.409 0.99
251_M 302_V 1.409 0.99
404_L 415_K 1.409 0.99
341_V 355_A 1.399 0.99
237_R 319_E 1.399 0.99
380_I 403_I 1.389 0.99
24_S 28_T 1.385 0.99
65_L 135_L 1.384 0.99
401_I 414_V 1.383 0.99
123_K 127_P 1.365 0.99
350_I 415_K 1.365 0.99
211_R 246_D 1.351 0.99
10_I 14_I 1.33 0.99
128_S 131_L 1.329 0.99
319_E 329_F 1.327 0.99
54_K 133_A 1.326 0.99
219_I 249_I 1.326 0.99
148_A 152_M 1.323 0.98
74_N 105_V 1.322 0.98
196_V 325_I 1.317 0.98
242_R 249_I 1.316 0.98
344_Q 350_I 1.309 0.98
48_S 52_V 1.294 0.98
11_I 15_I 1.286 0.98
348_S 415_K 1.285 0.98
344_Q 347_G 1.284 0.98
360_I 376_V 1.284 0.98
65_L 143_V 1.277 0.98
380_I 394_V 1.276 0.98
244_S 247_D 1.27 0.98
344_Q 415_K 1.268 0.98
360_I 416_V 1.267 0.98
383_A 396_I 1.267 0.98
221_D 226_I 1.266 0.98
218_D 221_D 1.265 0.98
404_L 413_Q 1.262 0.98
233_S 238_I 1.25 0.98
241_Y 248_A 1.242 0.97
286_T 291_Q 1.24 0.97
52_V 129_S 1.233 0.97
70_N 105_V 1.226 0.97
13_L 101_L 1.224 0.97
217_I 272_M 1.222 0.97
75_I 78_S 1.214 0.97
75_I 102_T 1.214 0.97
283_P 286_T 1.209 0.97
351_I 376_V 1.207 0.97
361_N 368_L 1.206 0.97
211_R 311_D 1.198 0.97
28_T 31_M 1.189 0.96
319_E 324_E 1.186 0.96
302_V 315_L 1.184 0.96
52_V 125_A 1.183 0.96
50_K 54_K 1.181 0.96
361_N 366_W 1.179 0.96
248_A 304_L 1.179 0.96
38_L 53_E 1.178 0.96
25_G 124_V 1.171 0.96
230_L 238_I 1.17 0.96
207_I 321_I 1.16 0.96
357_V 361_N 1.153 0.96
219_I 273_L 1.148 0.95
48_S 130_F 1.146 0.95
343_P 346_D 1.146 0.95
110_E 114_K 1.144 0.95
252_L 275_A 1.135 0.95
93_G 97_A 1.132 0.95
398_E 418_P 1.123 0.95
70_N 111_V 1.122 0.95
130_F 134_P 1.11 0.94
39_R 53_E 1.109 0.94
213_E 410_M 1.108 0.94
78_S 82_T 1.106 0.94
243_D 247_D 1.106 0.94
342_T 350_I 1.102 0.94
67_L 71_N 1.099 0.94
319_E 331_T 1.098 0.94
341_V 351_I 1.095 0.94
218_D 243_D 1.093 0.94
215_I 235_H 1.092 0.94
116_I 159_I 1.092 0.94
170_S 174_L 1.09 0.94
319_E 334_S 1.089 0.93
46_N 49_A 1.089 0.93
399_Y 416_V 1.089 0.93
55_L 62_L 1.088 0.93
323_E 332_S 1.087 0.93
323_E 334_S 1.087 0.93
379_V 401_I 1.087 0.93
215_I 238_I 1.082 0.93
394_V 401_I 1.08 0.93
249_I 276_A 1.08 0.93
12_I 15_I 1.08 0.93
20_S 67_L 1.078 0.93
171_K 201_K 1.076 0.93
381_L 387_I 1.07 0.93
71_N 102_T 1.064 0.92
67_L 74_N 1.063 0.92
112_L 153_L 1.062 0.92
137_I 140_M 1.057 0.92
20_S 71_N 1.055 0.92
353_G 376_V 1.055 0.92
171_K 175_R 1.054 0.92
42_A 50_K 1.049 0.92
27_E 114_K 1.043 0.91
380_I 384_L 1.042 0.91
20_S 105_V 1.034 0.91
279_I 304_L 1.033 0.91
399_Y 418_P 1.033 0.91
215_I 229_Q 1.033 0.91
211_R 307_N 1.031 0.91
71_N 105_V 1.031 0.91
22_Y 128_S 1.027 0.91
373_A 382_E 1.025 0.90
99_G 103_F 1.022 0.90
221_D 229_Q 1.019 0.90
24_S 105_V 1.018 0.90
239_V 304_L 1.017 0.90
82_T 86_M 1.012 0.90
48_S 126_Y 1.008 0.89
308_E 378_G 1.006 0.89
19_I 73_V 1.003 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hg0A10.67291000.517Contact Map0.728
3lhhA10.39721000.78Contact Map0.819
3ocoA20.355199.90.788Contact Map0.81
3ocmA20.404299.90.795Contact Map0.813
2v8qE10.598199.90.796Contact Map0.517
3oi8A20.359899.90.796Contact Map0.824
3kxrA10.450999.90.804Contact Map0.603
3lv9A10.345899.90.807Contact Map0.798
3dedA60.252399.90.808Contact Map0.796
3t4nC10.581899.90.813Contact Map0.498
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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