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YHIN - Uncharacterized protein YhiN
UniProt: P37631 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12229
Length: 400 (395)
Sequences: 5091
Seq/Len: 12.89
YHIN
Paralog alert: 0.68 [within 20: 0.05] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
18_C 156_V 3.574 1.00
30_L 126_R 3.302 1.00
4_F 30_L 3.28 1.00
5_D 153_E 3.127 1.00
4_F 7_I 2.995 1.00
156_V 394_L 2.989 1.00
71_K 75_A 2.944 1.00
131_V 176_I 2.897 1.00
177_A 344_V 2.858 1.00
117_E 120_K 2.806 1.00
78_T 81_D 2.7 1.00
133_S 179_Q 2.688 1.00
13_A 42_I 2.587 1.00
183_N 345_D 2.552 1.00
21_L 392_Q 2.503 1.00
34_N 172_F 2.502 1.00
387_A 391_A 2.484 1.00
256_N 322_T 2.409 1.00
28_R 124_T 2.396 1.00
157_I 368_V 2.375 1.00
157_I 177_A 2.341 1.00
14_A 365_I 2.335 1.00
363_Y 393_D 2.26 1.00
159_T 173_G 2.25 1.00
82_F 384_W 2.237 1.00
118_C 123_V 2.235 1.00
350_S 355_E 2.194 1.00
118_C 125_F 2.181 1.00
18_C 365_I 2.162 1.00
84_D 88_K 2.156 1.00
370_D 373_G 2.149 1.00
5_D 28_R 2.139 1.00
34_N 170_S 2.115 1.00
3_R 151_G 2.107 1.00
7_I 150_V 2.103 1.00
7_I 32_I 2.095 1.00
126_R 150_V 2.087 1.00
390_C 394_L 2.085 1.00
173_G 368_V 2.078 1.00
11_A 38_P 2.01 1.00
23_G 123_V 2.008 1.00
16_M 118_C 1.985 1.00
182_L 356_A 1.979 1.00
158_A 365_I 1.968 1.00
177_A 182_L 1.948 1.00
6_A 156_V 1.915 1.00
22_A 391_A 1.871 1.00
388_W 392_Q 1.856 1.00
21_L 24_Q 1.837 1.00
6_A 22_A 1.831 1.00
30_L 150_V 1.828 1.00
152_C 155_L 1.81 1.00
13_A 383_A 1.808 1.00
21_L 391_A 1.804 1.00
9_I 157_I 1.801 1.00
4_F 28_R 1.796 1.00
173_G 177_A 1.785 1.00
132_L 144_D 1.761 1.00
117_E 121_G 1.73 1.00
364_F 368_V 1.721 1.00
68_H 348_E 1.704 1.00
391_A 395_I 1.691 1.00
73_A 381_Q 1.682 1.00
156_V 365_I 1.676 1.00
65_Q 70_C 1.663 1.00
51_N 377_G 1.648 1.00
32_I 150_V 1.639 1.00
349_L 369_M 1.632 1.00
6_A 27_R 1.623 1.00
116_D 120_K 1.615 1.00
81_D 84_D 1.606 1.00
126_R 129_S 1.601 1.00
157_I 344_V 1.595 1.00
16_M 31_L 1.593 1.00
22_A 394_L 1.57 1.00
27_R 394_L 1.566 1.00
36_K 128_R 1.565 1.00
294_R 298_L 1.557 1.00
38_P 127_L 1.551 1.00
134_V 155_L 1.53 1.00
20_A 121_G 1.527 1.00
38_P 125_F 1.517 1.00
78_T 389_A 1.515 1.00
24_Q 121_G 1.514 1.00
304_V 313_D 1.513 1.00
159_T 368_V 1.507 1.00
32_I 143_L 1.496 1.00
184_V 187_T 1.49 1.00
350_S 357_R 1.482 1.00
7_I 30_L 1.48 1.00
59_P 75_A 1.477 1.00
22_A 27_R 1.473 1.00
141_F 359_V 1.471 1.00
7_I 152_C 1.464 1.00
91_I 113_M 1.462 1.00
69_F 346_T 1.451 1.00
133_S 142_T 1.449 1.00
23_G 121_G 1.443 1.00
21_L 25_A 1.439 1.00
115_V 119_E 1.429 1.00
72_S 389_A 1.429 1.00
161_G 340_T 1.428 1.00
34_N 130_E 1.425 1.00
154_K 394_L 1.423 1.00
19_S 123_V 1.418 1.00
157_I 362_L 1.413 1.00
216_I 240_V 1.41 1.00
35_G 168_G 1.4 0.99
19_S 31_L 1.393 0.99
67_P 71_K 1.392 0.99
6_A 154_K 1.39 0.99
18_C 390_C 1.389 0.99
25_A 392_Q 1.386 0.99
140_G 360_P 1.386 0.99
6_A 394_L 1.367 0.99
8_I 29_V 1.358 0.99
344_V 368_V 1.344 0.99
7_I 141_F 1.343 0.99
38_P 115_V 1.343 0.99
9_I 131_V 1.331 0.99
176_I 179_Q 1.322 0.99
11_A 31_L 1.312 0.99
91_I 110_I 1.311 0.99
31_L 125_F 1.309 0.99
175_K 178_E 1.309 0.99
5_D 30_L 1.308 0.99
129_S 150_V 1.307 0.99
82_F 385_S 1.301 0.99
108_Q 112_D 1.293 0.99
136_K 139_T 1.293 0.99
84_D 87_N 1.287 0.99
20_A 118_C 1.279 0.99
182_L 358_K 1.276 0.99
185_L 345_D 1.276 0.99
30_L 124_T 1.276 0.99
305_S 308_Q 1.27 0.99
173_G 176_I 1.257 0.99
85_L 388_W 1.242 0.98
154_K 397_A 1.227 0.98
293_E 297_Q 1.225 0.98
142_T 149_T 1.221 0.98
145_L 148_M 1.22 0.98
162_L 340_T 1.215 0.98
89_H 117_E 1.214 0.98
292_V 296_Q 1.213 0.98
16_M 115_V 1.191 0.98
339_V 379_N 1.187 0.98
130_E 172_F 1.184 0.98
43_L 111_V 1.184 0.98
137_D 140_G 1.179 0.98
24_Q 117_E 1.158 0.97
136_K 180_F 1.154 0.97
134_V 180_F 1.146 0.97
80_W 84_D 1.145 0.97
280_K 292_V 1.145 0.97
183_N 348_E 1.144 0.97
21_L 388_W 1.144 0.97
24_Q 89_H 1.144 0.97
27_R 391_A 1.138 0.97
42_I 111_V 1.136 0.97
382_W 386_S 1.131 0.97
32_I 129_S 1.116 0.96
391_A 394_L 1.103 0.96
348_E 358_K 1.098 0.96
8_I 156_V 1.084 0.96
4_F 124_T 1.084 0.96
20_A 117_E 1.081 0.95
9_I 159_T 1.078 0.95
116_D 119_E 1.076 0.95
155_L 361_G 1.074 0.95
288_P 291_L 1.074 0.95
215_V 223_V 1.073 0.95
11_A 16_M 1.072 0.95
357_R 364_F 1.071 0.95
18_C 387_A 1.071 0.95
32_I 126_R 1.069 0.95
262_D 265_T 1.065 0.95
28_R 153_E 1.064 0.95
157_I 364_F 1.062 0.95
4_F 126_R 1.06 0.95
178_E 184_V 1.051 0.94
381_Q 385_S 1.04 0.94
33_D 127_L 1.039 0.94
344_V 364_F 1.037 0.94
78_T 392_Q 1.034 0.94
75_A 78_T 1.031 0.94
374_W 378_Y 1.03 0.94
76_R 389_A 1.029 0.94
182_L 359_V 1.028 0.94
60_G 71_K 1.025 0.93
134_V 176_I 1.024 0.93
163_S 337_A 1.019 0.93
225_R 260_D 1.016 0.93
26_G 29_V 1.015 0.93
208_A 212_V 1.015 0.93
45_S 380_F 1.011 0.93
72_S 386_S 1.01 0.93
137_D 151_G 1.008 0.93
17_F 85_L 1.006 0.93
139_T 360_P 1.006 0.93
176_I 180_F 1.004 0.93
389_A 393_D 1.002 0.92
24_Q 88_K 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i0zA10.9951000.311Contact Map0.783
4c3xA80.93751000.322Contact Map0.701
4at0A10.91251000.333Contact Map0.728
1y0pA10.931000.345Contact Map0.723
1qo8A20.9251000.345Contact Map0.76
1d4dA10.931000.373Contact Map0.712
3v76A10.981000.376Contact Map0.699
2wdqA30.871000.413Contact Map0.761
2h88A20.8951000.426Contact Map0.741
2bs2A20.8651000.44Contact Map0.707
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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