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OPENSEQ.org
TAUD - Alpha-ketoglutarate-dependent taurine dioxygenase
UniProt: P37610 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12423
Length: 283 (277)
Sequences: 1376
Seq/Len: 4.97
TAUD
Paralog alert: 0.31 [within 20: 0.05] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
29_D 63_R 3.246 1.00
140_V 143_R 3.211 1.00
61_A 271_A 3.176 1.00
53_T 56_Q 2.765 1.00
147_S 198_Q 2.691 1.00
46_F 246_A 2.66 1.00
39_V 45_V 2.658 1.00
125_D 237_R 2.634 1.00
132_I 197_K 2.533 1.00
18_I 45_V 2.532 1.00
40_L 194_V 2.53 1.00
136_E 197_K 2.491 1.00
238_W 244_D 2.486 1.00
17_Q 48_R 2.436 1.00
116_A 119_L 2.326 1.00
28_S 31_Q 2.282 1.00
137_A 234_F 2.281 1.00
219_E 223_S 2.248 1.00
151_A 207_T 2.155 1.00
37_H 41_R 2.081 1.00
215_E 219_E 2.061 1.00
133_A 137_A 2.026 1.00
32_F 63_R 2.006 1.00
146_L 225_L 2.005 1.00
46_F 238_W 1.932 1.00
111_G 273_I 1.909 1.00
36_Y 194_V 1.899 1.00
121_S 264_Q 1.899 1.00
189_V 200_L 1.886 1.00
113_I 245_I 1.882 1.00
40_L 195_S 1.858 1.00
8_T 17_Q 1.855 1.00
6_S 19_S 1.809 1.00
16_A 42_H 1.808 1.00
8_T 19_S 1.799 1.00
7_I 38_A 1.79 1.00
151_A 188_V 1.771 1.00
43_Q 132_I 1.768 1.00
150_R 185_L 1.75 1.00
185_L 211_V 1.739 1.00
103_T 153_H 1.738 1.00
152_E 211_V 1.709 1.00
139_S 142_F 1.696 0.99
140_V 144_Q 1.688 0.99
135_Y 143_R 1.678 0.99
191_T 198_Q 1.662 0.99
22_D 25_R 1.64 0.99
207_T 226_F 1.607 0.99
238_W 246_A 1.599 0.99
223_S 227_A 1.584 0.99
23_L 50_Q 1.534 0.99
98_W 129_T 1.532 0.99
190_R 278_P 1.529 0.99
152_E 209_R 1.526 0.99
111_G 247_I 1.524 0.99
43_Q 130_S 1.522 0.99
116_A 268_M 1.517 0.99
144_Q 148_G 1.496 0.98
150_R 212_D 1.484 0.98
241_Q 244_D 1.483 0.98
54_P 269_H 1.481 0.98
58_R 79_V 1.47 0.98
55_Q 59_A 1.464 0.98
132_I 199_A 1.463 0.98
36_Y 110_A 1.457 0.98
56_Q 59_A 1.451 0.98
135_Y 147_S 1.445 0.98
16_A 38_A 1.437 0.98
134_A 200_L 1.435 0.98
146_L 189_V 1.424 0.98
207_T 222_L 1.402 0.97
128_W 253_T 1.39 0.97
191_T 279_F 1.37 0.97
118_E 265_R 1.354 0.97
58_R 81_E 1.35 0.96
144_Q 147_S 1.323 0.96
102_V 206_F 1.314 0.96
275_G 278_P 1.31 0.96
131_G 229_I 1.305 0.96
141_P 145_L 1.302 0.95
9_P 42_H 1.298 0.95
202_V 207_T 1.261 0.94
49_D 241_Q 1.26 0.94
128_W 246_A 1.253 0.94
43_Q 197_K 1.252 0.94
29_D 32_F 1.247 0.94
100_T 253_T 1.247 0.94
127_L 232_P 1.238 0.94
48_R 241_Q 1.237 0.94
127_L 258_N 1.237 0.94
114_L 240_W 1.229 0.93
46_F 128_W 1.223 0.93
49_D 244_D 1.21 0.93
135_Y 198_Q 1.205 0.92
52_I 243_N 1.194 0.92
103_T 201_F 1.188 0.92
23_L 245_I 1.184 0.91
33_E 37_H 1.183 0.91
33_E 36_Y 1.174 0.91
62_Q 81_E 1.166 0.91
132_I 136_E 1.166 0.91
188_V 210_I 1.165 0.91
39_V 111_G 1.157 0.90
59_A 62_Q 1.154 0.90
125_D 239_R 1.148 0.90
52_I 245_I 1.137 0.89
110_A 275_G 1.129 0.89
137_A 233_E 1.123 0.88
35_L 47_L 1.119 0.88
9_P 41_R 1.114 0.88
52_I 56_Q 1.114 0.88
106_E 277_K 1.111 0.88
109_P 112_A 1.111 0.88
149_L 221_L 1.11 0.88
60_L 247_I 1.109 0.87
47_L 247_I 1.109 0.87
209_R 218_S 1.103 0.87
49_D 243_N 1.094 0.87
133_A 136_E 1.092 0.86
152_E 183_P 1.087 0.86
61_A 113_I 1.083 0.86
257_A 261_Y 1.077 0.85
14_I 130_S 1.072 0.85
142_F 224_F 1.071 0.85
192_H 249_D 1.069 0.85
188_V 207_T 1.068 0.85
220_A 223_S 1.059 0.84
130_S 136_E 1.058 0.84
119_L 242_P 1.048 0.83
228_H 234_F 1.048 0.83
136_E 143_R 1.034 0.82
139_S 224_F 1.03 0.82
138_L 143_R 1.015 0.80
58_R 62_Q 1.007 0.80
47_L 57_Q 1.005 0.79
153_H 206_F 1.005 0.79
102_V 109_P 1.004 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1otjA411000.25Contact Map0.812
3pvjA40.97881000.264Contact Map0.794
1oihA40.98941000.276Contact Map0.789
3r1jA20.97881000.287Contact Map0.782
4j5iA80.96821000.302Contact Map0.804
3eatX10.93991000.326Contact Map0.577
1nx8A30.90461000.352Contact Map0.568
2q4aA20.93641000.448Contact Map0.572
3o2gA10.92231000.449Contact Map0.402
1ds1A10.91521000.475Contact Map0.36
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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