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OPENSEQ.org
UCPA - Oxidoreductase UcpA
UniProt: P37440 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12133
Length: 263 (251)
Sequences: 49178
Seq/Len: 195.93
UCPA
Paralog alert: 0.89 [within 20: 0.47] - ratio of genomes with paralogs
Cluster includes: BDCA ENTA FABG FABI FOLM HCAB HDHA IDNO KDUD SRLD UCPA YBBO YCIK YDFG YGCW YGFF YGHA YOHF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
107_D 115_K 3.237 1.00
107_D 111_D 2.893 1.00
160_A 164_G 2.781 1.00
65_D 68_S 2.771 1.00
138_M 166_T 2.592 1.00
135_R 179_R 2.563 1.00
9_A 85_I 2.333 1.00
77_K 127_E 2.319 1.00
20_E 24_R 2.314 1.00
121_T 169_L 2.212 1.00
184_C 246_Q 2.204 1.00
140_S 163_V 2.201 1.00
70_A 123_A 2.192 1.00
40_P 43_E 2.183 1.00
129_I 176_S 2.148 1.00
189_R 223_D 2.128 1.00
88_N 138_M 2.116 1.00
85_I 235_A 2.084 1.00
25_T 229_E 2.052 1.00
32_N 55_R 1.952 1.00
111_D 115_K 1.945 1.00
73_I 124_V 1.934 1.00
125_L 173_Y 1.921 1.00
66_P 103_D 1.897 1.00
25_T 232_A 1.886 1.00
25_T 29_H 1.851 1.00
8_T 32_N 1.839 1.00
36_L 61_A 1.837 1.00
113_N 158_T 1.796 1.00
245_T 248_V 1.792 1.00
22_I 231_A 1.791 1.00
229_E 238_E 1.769 1.00
117_V 162_I 1.761 1.00
18_I 188_V 1.756 1.00
24_R 48_E 1.734 1.00
20_E 45_L 1.694 1.00
166_T 182_A 1.693 1.00
15_L 37_D 1.684 1.00
20_E 48_E 1.672 1.00
230_L 247_N 1.662 1.00
75_R 79_K 1.652 1.00
14_A 35_L 1.629 1.00
26_F 235_A 1.627 1.00
74_K 78_E 1.595 1.00
42_I 58_A 1.591 1.00
34_I 76_A 1.57 1.00
29_H 232_A 1.568 1.00
57_T 79_K 1.563 1.00
34_I 80_E 1.562 1.00
114_I 161_A 1.56 1.00
36_L 72_A 1.551 1.00
110_I 114_I 1.518 1.00
71_A 75_R 1.511 1.00
31_A 85_I 1.504 1.00
25_T 28_R 1.502 1.00
222_A 241_Y 1.479 1.00
70_A 74_K 1.478 1.00
61_A 68_S 1.477 1.00
102_S 105_D 1.468 1.00
8_T 82_R 1.459 1.00
86_L 120_V 1.448 1.00
9_A 26_F 1.442 1.00
103_D 119_N 1.433 1.00
87_V 139_M 1.428 1.00
43_E 47_D 1.428 1.00
75_R 78_E 1.413 1.00
16_Q 191_P 1.385 0.99
135_R 181_N 1.373 0.99
40_P 60_V 1.372 0.99
6_G 31_A 1.365 0.99
188_V 222_A 1.317 0.99
183_I 231_A 1.315 0.99
69_V 120_V 1.314 0.99
88_N 121_T 1.312 0.99
61_A 72_A 1.31 0.99
66_P 119_N 1.292 0.99
46_A 50_C 1.287 0.99
68_S 71_A 1.268 0.99
4_L 31_A 1.264 0.99
23_A 35_L 1.263 0.99
59_V 75_R 1.253 0.99
115_K 119_N 1.245 0.98
166_T 180_V 1.241 0.98
127_E 131_R 1.24 0.98
140_S 182_A 1.238 0.98
66_P 70_A 1.236 0.98
9_A 31_A 1.234 0.98
121_T 136_I 1.228 0.98
32_N 54_H 1.226 0.98
21_G 225_L 1.223 0.98
21_G 24_R 1.222 0.98
46_A 58_A 1.222 0.98
230_L 249_I 1.217 0.98
26_F 31_A 1.199 0.98
169_L 180_V 1.193 0.98
83_I 124_V 1.184 0.98
47_D 51_G 1.167 0.97
24_R 28_R 1.167 0.97
103_D 115_K 1.147 0.97
47_D 50_C 1.143 0.97
67_A 71_A 1.137 0.97
25_T 228_G 1.137 0.97
99_L 129_I 1.134 0.97
86_L 124_V 1.119 0.96
94_R 108_F 1.118 0.96
92_V 112_I 1.103 0.96
57_T 80_E 1.102 0.96
110_I 115_K 1.101 0.96
8_T 34_I 1.096 0.96
59_V 72_A 1.095 0.96
71_A 74_K 1.08 0.95
82_R 131_R 1.077 0.95
28_R 52_R 1.075 0.95
155_Y 159_K 1.073 0.95
104_D 108_F 1.072 0.95
96_G 105_D 1.065 0.95
146_M 248_V 1.064 0.95
106_R 115_K 1.064 0.95
89_N 139_M 1.063 0.95
182_A 246_Q 1.062 0.95
10_L 72_A 1.062 0.95
43_E 46_A 1.061 0.95
118_W 165_L 1.055 0.95
22_I 87_V 1.053 0.95
139_M 231_A 1.052 0.95
163_V 246_Q 1.04 0.94
35_L 56_C 1.039 0.94
64_R 108_F 1.025 0.93
18_I 22_I 1.023 0.93
26_F 232_A 1.019 0.93
21_G 224_P 1.019 0.93
97_S 100_D 1.018 0.93
32_N 57_T 1.017 0.93
233_F 242_L 1.014 0.93
63_V 116_G 1.01 0.93
44_K 48_E 1.003 0.93
22_I 228_G 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2c07A10.93541000.115Contact Map0.744
1vl8A20.94681000.117Contact Map0.787
4fn4A40.95441000.119Contact Map0.924
4iboA40.95061000.12Contact Map0.841
4j2hA10.95061000.12Contact Map0.75
4egfA80.94681000.12Contact Map0.821
3pk0A40.96581000.12Contact Map0.754
2rhcB20.96961000.12Contact Map0.82
3cxtA10.9811000.122Contact Map0.698
1iy8A80.97341000.122Contact Map0.88
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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