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OPENSEQ.org
XYLG - Xylose import ATP-binding protein XylG
UniProt: P37388 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12275
Length: 513 (499)
Sequences: 14258
Seq/Len: 28.57
XYLG
Paralog alert: 0.93 [within 20: 0.27] - ratio of genomes with paralogs
Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
31_E 211_T 4.59 1.00
263_H 279_D 4.461 1.00
9_N 22_N 4.447 1.00
260_R 283_S 4.208 1.00
21_D 219_Q 4.109 1.00
262_E 318_K 3.969 1.00
288_E 474_R 3.802 1.00
8_K 62_E 3.781 1.00
304_I 461_I 3.635 1.00
62_E 69_E 3.44 1.00
261_I 264_L 3.406 1.00
6_E 26_R 3.373 1.00
33_V 213_C 3.36 1.00
7_M 10_I 3.235 1.00
260_R 320_Y 3.198 1.00
18_K 21_D 3.034 1.00
305_Q 311_W 2.907 1.00
318_K 325_Q 2.904 1.00
290_L 476_L 2.766 1.00
278_N 482_K 2.758 1.00
34_S 209_S 2.68 1.00
11_T 22_N 2.622 1.00
6_E 64_I 2.619 1.00
291_G 472_S 2.6 1.00
225_D 228_G 2.576 1.00
261_I 282_F 2.565 1.00
389_I 399_P 2.522 1.00
122_R 125_K 2.511 1.00
338_G 425_R 2.497 1.00
66_A 162_R 2.482 1.00
322_D 425_R 2.452 1.00
47_M 198_I 2.413 1.00
115_D 118_L 2.408 1.00
263_H 281_S 2.395 1.00
9_N 24_C 2.362 1.00
186_R 207_A 2.357 1.00
262_E 320_Y 2.318 1.00
266_A 306_C 2.302 1.00
129_Q 191_H 2.205 1.00
462_S 468_V 2.204 1.00
13_T 18_K 2.183 1.00
266_A 315_W 2.182 1.00
257_E 260_R 2.176 1.00
138_T 142_D 2.163 1.00
286_R 425_R 2.116 1.00
82_G 162_R 2.075 1.00
265_T 279_D 2.067 1.00
306_C 314_Q 2.063 1.00
118_L 122_R 2.035 1.00
304_I 428_I 2.019 1.00
14_F 54_Y 2.009 1.00
303_T 478_M 2.002 1.00
354_V 404_G 1.999 1.00
7_M 25_L 1.979 1.00
476_L 486_N 1.961 1.00
28_N 31_E 1.954 1.00
120_T 137_D 1.935 1.00
450_Q 454_Q 1.932 1.00
11_T 18_K 1.922 1.00
122_R 160_Q 1.914 1.00
265_T 316_E 1.914 1.00
213_C 220_H 1.828 1.00
209_S 226_A 1.824 1.00
72_A 81_K 1.82 1.00
285_K 288_E 1.815 1.00
97_T 100_E 1.803 1.00
284_L 290_L 1.797 1.00
74_H 77_D 1.794 1.00
282_F 476_L 1.792 1.00
124_Q 128_A 1.782 1.00
256_D 286_R 1.777 1.00
8_K 64_I 1.773 1.00
460_V 471_L 1.769 1.00
7_M 50_L 1.744 1.00
102_I 158_N 1.739 1.00
275_K 278_N 1.739 1.00
84_A 156_A 1.706 1.00
121_L 125_K 1.705 1.00
69_E 72_A 1.704 1.00
185_I 195_C 1.694 1.00
291_G 468_V 1.677 1.00
95_E 141_G 1.667 1.00
27_L 163_L 1.662 1.00
86_I 166_L 1.66 1.00
262_E 281_S 1.66 1.00
388_S 421_L 1.658 1.00
387_E 391_Q 1.656 1.00
358_G 400_D 1.648 1.00
29_A 162_R 1.64 1.00
308_F 428_I 1.634 1.00
425_R 456_I 1.613 1.00
224_R 229_M 1.601 1.00
406_L 414_A 1.584 1.00
32_I 185_I 1.583 1.00
485_A 500_A 1.559 1.00
436_I 444_I 1.552 1.00
284_L 457_A 1.552 1.00
388_S 417_A 1.55 1.00
391_Q 450_Q 1.548 1.00
4_L 194_A 1.543 1.00
263_H 316_E 1.537 1.00
233_D 236_T 1.533 1.00
73_S 77_D 1.526 1.00
139_R 142_D 1.516 1.00
222_G 237_M 1.513 1.00
261_I 307_L 1.504 1.00
389_I 396_T 1.502 1.00
135_S 138_T 1.5 1.00
206_K 227_A 1.497 1.00
257_E 283_S 1.496 1.00
352_V 363_L 1.489 1.00
403_I 414_A 1.487 1.00
398_S 401_L 1.483 1.00
262_E 283_S 1.472 1.00
476_L 483_L 1.47 1.00
8_K 26_R 1.47 1.00
211_T 223_T 1.469 1.00
162_R 193_I 1.469 1.00
286_R 457_A 1.462 1.00
25_L 213_C 1.462 1.00
8_K 24_C 1.458 1.00
264_L 314_Q 1.45 1.00
11_T 58_S 1.442 1.00
257_E 285_K 1.43 1.00
12_K 49_V 1.423 1.00
126_L 158_N 1.421 1.00
10_I 49_V 1.421 1.00
377_D 380_A 1.419 1.00
355_M 359_K 1.412 1.00
129_Q 187_D 1.412 1.00
27_L 33_V 1.41 1.00
267_W 315_W 1.404 0.99
386_L 399_P 1.386 0.99
289_I 448_I 1.364 0.99
187_D 191_H 1.362 0.99
261_I 319_I 1.36 0.99
356_A 359_K 1.358 0.99
342_V 429_L 1.357 0.99
284_L 426_I 1.356 0.99
51_C 85_I 1.35 0.99
144_G 147_Q 1.348 0.99
13_T 58_S 1.346 0.99
65_F 163_L 1.343 0.99
92_L 140_V 1.334 0.99
277_V 280_V 1.329 0.99
474_R 486_N 1.324 0.99
183_D 187_D 1.323 0.99
118_L 121_L 1.321 0.99
12_K 45_T 1.321 0.99
179_S 207_A 1.311 0.99
53_I 87_H 1.295 0.99
189_Q 210_D 1.293 0.99
199_S 205_V 1.291 0.99
492_L 496_Q 1.29 0.99
321_I 426_I 1.281 0.99
266_A 311_W 1.275 0.99
5_L 65_F 1.272 0.99
125_K 129_Q 1.27 0.99
384_C 387_E 1.27 0.99
386_L 390_Q 1.248 0.99
288_E 473_D 1.243 0.98
498_M 501_A 1.236 0.98
401_L 405_R 1.222 0.98
290_L 459_I 1.215 0.98
103_F 123_C 1.214 0.98
187_D 190_Q 1.214 0.98
3_Y 28_N 1.211 0.98
448_I 458_V 1.211 0.98
362_T 381_E 1.21 0.98
9_N 58_S 1.207 0.98
358_G 399_P 1.206 0.98
357_V 414_A 1.205 0.98
339_I 426_I 1.203 0.98
127_L 136_P 1.2 0.98
264_L 306_C 1.183 0.98
64_I 69_E 1.183 0.98
22_N 219_Q 1.182 0.98
49_V 63_I 1.182 0.98
279_D 482_K 1.18 0.98
186_R 189_Q 1.176 0.98
360_N 418_R 1.175 0.98
488_I 491_N 1.171 0.98
489_N 492_L 1.168 0.97
321_I 326_V 1.166 0.97
402_A 405_R 1.163 0.97
487_L 500_A 1.162 0.97
429_L 448_I 1.16 0.97
99_L 123_C 1.153 0.97
292_I 476_L 1.149 0.97
47_M 165_I 1.148 0.97
65_F 83_I 1.14 0.97
49_V 56_H 1.129 0.97
383_K 387_E 1.128 0.97
31_E 210_D 1.124 0.97
14_F 45_T 1.123 0.97
124_Q 136_P 1.12 0.96
20_I 23_V 1.12 0.96
351_I 403_I 1.116 0.96
130_V 154_A 1.114 0.96
94_K 148_Q 1.113 0.96
47_M 85_I 1.113 0.96
179_S 183_D 1.104 0.96
143_L 151_V 1.103 0.96
380_A 383_K 1.102 0.96
148_Q 345_D 1.099 0.96
11_T 21_D 1.099 0.96
265_T 278_N 1.098 0.96
68_E 77_D 1.098 0.96
10_I 56_H 1.096 0.96
120_T 124_Q 1.091 0.96
103_F 119_M 1.089 0.96
257_E 286_R 1.087 0.96
352_V 355_M 1.086 0.96
493_T 496_Q 1.083 0.96
340_A 424_P 1.079 0.95
234_I 238_M 1.079 0.95
93_V 104_L 1.076 0.95
236_T 242_E 1.072 0.95
282_F 303_T 1.072 0.95
258_I 457_A 1.069 0.95
209_S 212_I 1.062 0.95
7_M 63_I 1.062 0.95
475_V 492_L 1.062 0.95
99_L 120_T 1.059 0.95
224_R 228_G 1.056 0.95
5_L 50_L 1.056 0.95
34_S 205_V 1.055 0.95
84_A 161_V 1.052 0.95
382_Q 386_L 1.051 0.94
140_V 151_V 1.05 0.94
12_K 54_Y 1.049 0.94
277_V 306_C 1.045 0.94
267_W 275_K 1.045 0.94
292_I 303_T 1.042 0.94
14_F 19_A 1.03 0.94
468_V 472_S 1.03 0.94
320_Y 325_Q 1.03 0.94
44_S 48_K 1.028 0.94
230_S 233_D 1.024 0.93
33_V 223_T 1.024 0.93
347_K 411_Q 1.022 0.93
306_C 319_I 1.02 0.93
258_I 322_D 1.019 0.93
29_A 194_A 1.018 0.93
12_K 57_G 1.016 0.93
389_I 394_V 1.015 0.93
300_R 431_E 1.012 0.93
50_L 196_I 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4finA20.90451000.226Contact Map0.758
3g5uA20.96691000.235Contact Map0.644
4f4cA10.9611000.237Contact Map0.711
1yqtA10.91231000.291Contact Map0.651
2iw3A20.86741000.294Contact Map0.736
3bk7A10.91231000.302Contact Map0.627
3ozxA20.89861000.31Contact Map0.677
3j16B10.92591000.318Contact Map0.449
3ux8A10.93181000.323Contact Map0.58
2vf7A30.93761000.429Contact Map0.555
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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