| UniProt: | P37355 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12438 | ||
| Length: | 252 (242) | ||
| Sequences: | 21373 | ||
| Seq/Len: | 88.32 |
| MENH
Paralog alert: 0.80 [within 20: 0.24] - ratio of genomes with paralogs Cluster includes: BIOH DLHH MENH MHPC PLDB RUTD YBFF YCJY YFHR YGHX YJFP |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 81_W | 105_G | 4.456 | 1.00 | |
| 48_P | 67_L | 4.043 | 1.00 | |
| 33_V | 243_I | 3.376 | 1.00 | |
| 208_E | 228_P | 3.18 | 1.00 | |
| 238_N | 241_G | 3.071 | 1.00 | |
| 203_Y | 249_I | 2.9 | 1.00 | |
| 225_H | 245_S | 2.845 | 1.00 | |
| 79_D | 104_C | 2.816 | 1.00 | |
| 69_R | 95_A | 2.796 | 1.00 | |
| 109_E | 242_V | 2.686 | 1.00 | |
| 81_W | 104_C | 2.679 | 1.00 | |
| 73_V | 102_G | 2.427 | 1.00 | |
| 69_R | 99_G | 2.317 | 1.00 | |
| 72_L | 80_F | 2.282 | 1.00 | |
| 39_D | 247_A | 2.264 | 1.00 | |
| 227_I | 245_S | 2.263 | 1.00 | |
| 110_G | 210_D | 2.233 | 1.00 | |
| 66_D | 98_Q | 2.166 | 1.00 | |
| 95_A | 99_G | 2.145 | 1.00 | |
| 208_E | 226_V | 2.144 | 1.00 | |
| 230_A | 238_N | 2.098 | 1.00 | |
| 82_L | 92_A | 2.057 | 1.00 | |
| 89_G | 111_G | 2.044 | 1.00 | |
| 107_I | 246_L | 1.999 | 1.00 | |
| 69_R | 73_V | 1.986 | 1.00 | |
| 96_A | 106_V | 1.917 | 1.00 | |
| 94_M | 98_Q | 1.915 | 1.00 | |
| 69_R | 102_G | 1.901 | 1.00 | |
| 81_W | 107_I | 1.865 | 1.00 | |
| 16_W | 41_S | 1.853 | 1.00 | |
| 16_W | 43_L | 1.839 | 1.00 | |
| 45_V | 68_L | 1.815 | 1.00 | |
| 81_W | 250_L | 1.799 | 1.00 | |
| 92_A | 106_V | 1.793 | 1.00 | |
| 36_A | 243_I | 1.757 | 1.00 | |
| 245_S | 248_Q | 1.742 | 1.00 | |
| 27_C | 52_G | 1.737 | 1.00 | |
| 34_G | 44_Y | 1.676 | 1.00 | |
| 20_L | 47_L | 1.664 | 1.00 | |
| 43_L | 71_T | 1.662 | 1.00 | |
| 194_N | 197_A | 1.62 | 1.00 | |
| 244_A | 248_Q | 1.611 | 1.00 | |
| 19_F | 42_R | 1.607 | 1.00 | |
| 19_F | 83_V | 1.604 | 1.00 | |
| 20_L | 68_L | 1.601 | 1.00 | |
| 99_G | 102_G | 1.6 | 1.00 | |
| 65_T | 94_M | 1.589 | 1.00 | |
| 62_D | 98_Q | 1.584 | 1.00 | |
| 20_L | 92_A | 1.568 | 1.00 | |
| 241_G | 245_S | 1.557 | 1.00 | |
| 68_L | 95_A | 1.552 | 1.00 | |
| 47_L | 91_V | 1.52 | 1.00 | |
| 227_I | 230_A | 1.512 | 1.00 | |
| 203_Y | 225_H | 1.505 | 1.00 | |
| 108_V | 111_G | 1.483 | 1.00 | |
| 25_G | 29_E | 1.483 | 1.00 | |
| 95_A | 103_L | 1.482 | 1.00 | |
| 18_V | 72_L | 1.481 | 1.00 | |
| 21_H | 50_H | 1.474 | 1.00 | |
| 15_P | 81_W | 1.466 | 1.00 | |
| 36_A | 247_A | 1.459 | 1.00 | |
| 215_A | 226_V | 1.449 | 1.00 | |
| 73_V | 99_G | 1.443 | 1.00 | |
| 77_I | 80_F | 1.424 | 1.00 | |
| 72_L | 77_I | 1.423 | 1.00 | |
| 94_M | 97_C | 1.417 | 1.00 | |
| 27_C | 46_D | 1.41 | 1.00 | |
| 242_V | 246_L | 1.403 | 0.99 | |
| 40_Y | 81_W | 1.398 | 0.99 | |
| 60_G | 63_D | 1.379 | 0.99 | |
| 27_C | 44_Y | 1.37 | 0.99 | |
| 85_Y | 235_H | 1.36 | 0.99 | |
| 205_L | 245_S | 1.358 | 0.99 | |
| 106_V | 202_F | 1.357 | 0.99 | |
| 16_W | 77_I | 1.352 | 0.99 | |
| 241_G | 244_A | 1.339 | 0.99 | |
| 107_I | 203_Y | 1.314 | 0.99 | |
| 24_S | 86_S | 1.31 | 0.99 | |
| 21_H | 47_L | 1.273 | 0.99 | |
| 95_A | 102_G | 1.273 | 0.99 | |
| 230_A | 237_E | 1.269 | 0.99 | |
| 45_V | 71_T | 1.264 | 0.99 | |
| 15_P | 104_C | 1.252 | 0.99 | |
| 71_T | 75_Y | 1.249 | 0.99 | |
| 46_D | 51_G | 1.24 | 0.98 | |
| 230_A | 234_A | 1.239 | 0.98 | |
| 18_V | 80_F | 1.205 | 0.98 | |
| 36_A | 240_A | 1.202 | 0.98 | |
| 83_V | 246_L | 1.197 | 0.98 | |
| 17_L | 83_V | 1.189 | 0.98 | |
| 93_M | 108_V | 1.186 | 0.98 | |
| 83_V | 109_E | 1.179 | 0.98 | |
| 97_C | 194_N | 1.178 | 0.98 | |
| 65_T | 91_V | 1.175 | 0.98 | |
| 40_Y | 251_R | 1.171 | 0.98 | |
| 69_R | 98_Q | 1.161 | 0.97 | |
| 80_F | 103_L | 1.153 | 0.97 | |
| 204_Y | 222_A | 1.148 | 0.97 | |
| 83_V | 107_I | 1.14 | 0.97 | |
| 208_E | 229_R | 1.14 | 0.97 | |
| 227_I | 241_G | 1.137 | 0.97 | |
| 22_G | 86_S | 1.132 | 0.97 | |
| 17_L | 40_Y | 1.128 | 0.97 | |
| 18_V | 68_L | 1.128 | 0.97 | |
| 40_Y | 250_L | 1.127 | 0.97 | |
| 240_A | 244_A | 1.126 | 0.97 | |
| 105_G | 201_A | 1.125 | 0.97 | |
| 43_L | 75_Y | 1.115 | 0.96 | |
| 227_I | 238_N | 1.114 | 0.96 | |
| 107_I | 250_L | 1.112 | 0.96 | |
| 82_L | 95_A | 1.11 | 0.96 | |
| 24_S | 50_H | 1.093 | 0.96 | |
| 158_D | 162_R | 1.084 | 0.96 | |
| 205_L | 227_I | 1.078 | 0.95 | |
| 29_E | 235_H | 1.069 | 0.95 | |
| 223_D | 245_S | 1.068 | 0.95 | |
| 225_H | 241_G | 1.063 | 0.95 | |
| 203_Y | 223_D | 1.049 | 0.94 | |
| 206_C | 226_V | 1.048 | 0.94 | |
| 206_C | 224_C | 1.039 | 0.94 | |
| 34_G | 42_R | 1.034 | 0.94 | |
| 105_G | 249_I | 1.019 | 0.93 | |
| 66_D | 70_K | 1.018 | 0.93 | |
| 72_L | 95_A | 1.017 | 0.93 | |
| 157_N | 160_Q | 1.017 | 0.93 | |
| 231_G | 237_E | 1.012 | 0.93 | |
| 109_E | 235_H | 1.01 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2xmzA | 1 | 0.996 | 100 | 0.083 | Contact Map | 0.778 |
| 3om8A | 2 | 0.9683 | 100 | 0.105 | Contact Map | 0.775 |
| 1ehyA | 4 | 0.9841 | 100 | 0.12 | Contact Map | 0.81 |
| 2xuaA | 2 | 0.9643 | 100 | 0.124 | Contact Map | 0.836 |
| 3bf7A | 2 | 0.9405 | 100 | 0.124 | Contact Map | 0.817 |
| 1r3dA | 1 | 0.996 | 100 | 0.139 | Contact Map | 0.707 |
| 3oosA | 1 | 0.9643 | 100 | 0.139 | Contact Map | 0.702 |
| 1womA | 2 | 0.9722 | 100 | 0.143 | Contact Map | 0.743 |
| 1zoiA | 3 | 0.9802 | 100 | 0.149 | Contact Map | 0.782 |
| 2wueA | 2 | 0.9881 | 100 | 0.149 | Contact Map | 0.848 |
Sequence Conservation (Image Generated using WebLogo v3)