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OPENSEQ.org
LHGO - L-2-hydroxyglutarate oxidase LhgO
UniProt: P37339 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12387
Length: 422 (380)
Sequences: 9161
Seq/Len: 24.11
LHGO
Paralog alert: 0.75 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: DADA LHGO MTOX PUUB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
158_F 163_G 5.286 1.00
2_Y 30_A 4.148 1.00
34_K 170_E 3.667 1.00
3_D 194_S 3.653 1.00
5_V 183_I 3.476 1.00
120_N 123_E 3.458 1.00
170_E 186_R 3.184 1.00
5_V 193_A 3.124 1.00
5_V 32_L 2.969 1.00
3_D 28_R 2.925 1.00
68_A 387_A 2.872 1.00
117_E 123_E 2.844 1.00
21_I 161_R 2.739 1.00
124_L 136_G 2.721 1.00
74_K 86_N 2.673 1.00
123_E 126_E 2.639 1.00
173_G 184_R 2.604 1.00
22_D 79_Q 2.546 1.00
16_T 197_I 2.535 1.00
30_A 166_I 2.531 1.00
99_M 135_G 2.432 1.00
32_L 191_Y 2.415 1.00
4_F 20_L 2.367 1.00
28_R 164_E 2.293 1.00
5_V 191_Y 2.223 1.00
14_M 151_T 2.151 1.00
27_A 394_Q 2.139 1.00
197_I 393_V 2.122 1.00
21_I 163_G 2.119 1.00
175_N 184_R 2.08 1.00
172_S 184_R 2.074 1.00
182_V 190_E 2.07 1.00
9_G 38_P 2.057 1.00
184_R 190_E 2.054 1.00
117_E 140_P 2.014 1.00
121_A 125_R 1.989 1.00
75_A 79_Q 1.975 1.00
4_F 27_A 1.941 1.00
224_G 346_R 1.895 1.00
9_G 33_E 1.894 1.00
2_Y 164_E 1.893 1.00
18_M 157_I 1.892 1.00
374_A 385_I 1.892 1.00
177_H 182_V 1.89 1.00
156_K 159_Q 1.881 1.00
19_Q 387_A 1.878 1.00
22_D 161_R 1.852 1.00
107_E 111_A 1.847 1.00
38_P 167_Y 1.836 1.00
320_S 324_R 1.834 1.00
230_A 337_D 1.833 1.00
174_L 196_L 1.806 1.00
14_M 155_A 1.801 1.00
9_G 31_L 1.788 1.00
119_L 123_E 1.782 1.00
103_R 118_W 1.757 1.00
175_N 182_V 1.747 1.00
18_M 22_D 1.736 1.00
195_T 369_I 1.736 1.00
107_E 110_A 1.721 1.00
195_T 393_V 1.716 1.00
157_I 160_S 1.712 1.00
371_T 385_I 1.707 1.00
369_I 389_I 1.705 1.00
38_P 155_A 1.705 1.00
19_Q 386_G 1.697 1.00
122_D 126_E 1.677 1.00
171_V 183_I 1.676 1.00
185_T 188_G 1.673 1.00
73_T 150_V 1.65 1.00
166_I 169_A 1.637 1.00
198_S 204_A 1.637 1.00
15_S 19_Q 1.624 1.00
21_I 158_F 1.615 1.00
386_G 390_V 1.606 1.00
2_Y 5_V 1.606 1.00
30_A 191_Y 1.601 1.00
371_T 389_I 1.599 1.00
5_V 30_A 1.597 1.00
115_E 141_S 1.59 1.00
369_I 393_V 1.587 1.00
106_W 110_A 1.579 1.00
14_M 158_F 1.572 1.00
155_A 165_I 1.564 1.00
182_V 192_E 1.553 1.00
6_I 17_A 1.553 1.00
103_R 107_E 1.549 1.00
32_L 171_V 1.547 1.00
123_E 127_R 1.541 1.00
35_E 40_C 1.521 1.00
19_Q 23_V 1.52 1.00
157_I 161_R 1.51 1.00
193_A 196_L 1.505 1.00
72_A 387_A 1.5 1.00
204_A 372_C 1.5 1.00
68_A 71_R 1.499 1.00
17_A 29_I 1.495 1.00
83_R 149_D 1.466 1.00
23_V 394_Q 1.465 1.00
7_I 200_S 1.445 1.00
96_D 100_E 1.441 1.00
12_I 371_T 1.436 1.00
14_M 31_L 1.435 1.00
36_S 168_N 1.433 1.00
16_T 199_C 1.432 1.00
15_S 386_G 1.405 0.99
32_L 166_I 1.404 0.99
12_I 374_A 1.404 0.99
3_D 27_A 1.399 0.99
200_S 207_L 1.377 0.99
100_E 103_R 1.375 0.99
104_A 107_E 1.374 0.99
93_A 102_M 1.367 0.99
23_V 390_V 1.365 0.99
173_G 210_M 1.363 0.99
198_S 370_H 1.357 0.99
23_V 391_S 1.357 0.99
31_L 165_I 1.348 0.99
388_H 391_S 1.343 0.99
119_L 127_R 1.342 0.99
39_A 151_T 1.338 0.99
175_N 190_E 1.326 0.99
15_S 382_A 1.317 0.99
88_G 140_P 1.313 0.99
146_S 149_D 1.305 0.99
6_I 16_T 1.301 0.99
169_A 185_T 1.296 0.99
35_E 41_H 1.295 0.99
72_A 75_A 1.284 0.99
20_L 390_V 1.265 0.99
11_I 382_A 1.26 0.99
45_H 342_P 1.257 0.99
3_D 30_A 1.254 0.99
11_I 43_T 1.247 0.99
323_L 327_Q 1.246 0.98
158_F 162_G 1.245 0.98
177_H 192_E 1.239 0.98
117_E 138_F 1.238 0.98
4_F 195_T 1.231 0.98
198_S 368_T 1.23 0.98
266_V 326_V 1.221 0.98
30_A 164_E 1.218 0.98
156_K 160_S 1.214 0.98
155_A 159_Q 1.211 0.98
99_M 103_R 1.207 0.98
172_S 186_R 1.206 0.98
324_R 328_K 1.201 0.98
207_L 210_M 1.192 0.98
68_A 72_A 1.19 0.98
198_S 208_V 1.179 0.98
32_L 193_A 1.178 0.98
16_T 371_T 1.167 0.97
18_M 161_R 1.161 0.97
15_S 154_M 1.159 0.97
7_I 171_V 1.151 0.97
106_W 118_W 1.15 0.97
17_A 163_G 1.149 0.97
106_W 137_I 1.148 0.97
88_G 138_F 1.146 0.97
263_S 339_Q 1.14 0.97
19_Q 22_D 1.132 0.97
206_R 209_K 1.13 0.97
2_Y 28_R 1.128 0.97
176_E 181_V 1.123 0.97
174_L 183_I 1.12 0.96
117_E 127_R 1.119 0.96
177_H 180_G 1.112 0.96
80_N 157_I 1.11 0.96
75_A 78_D 1.107 0.96
169_A 191_Y 1.104 0.96
16_T 386_G 1.101 0.96
69_G 384_P 1.095 0.96
95_S 98_E 1.08 0.95
145_V 150_V 1.074 0.95
99_M 118_W 1.066 0.95
100_E 104_A 1.066 0.95
325_L 328_K 1.063 0.95
387_A 391_S 1.062 0.95
93_A 99_M 1.059 0.95
17_A 31_L 1.059 0.95
185_T 191_Y 1.047 0.94
29_I 163_G 1.046 0.94
7_I 196_L 1.04 0.94
36_S 167_Y 1.037 0.94
84_Y 143_G 1.032 0.94
127_R 138_F 1.032 0.94
316_S 320_S 1.026 0.94
199_C 371_T 1.025 0.93
181_V 196_L 1.025 0.93
229_L 266_V 1.022 0.93
68_A 384_P 1.019 0.93
73_T 382_A 1.016 0.93
38_P 165_I 1.012 0.93
7_I 207_L 1.01 0.93
71_R 75_A 1.007 0.93
74_K 78_D 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nycA10.83651000.38Contact Map0.724
3axbA10.86261000.409Contact Map0.716
1ryiA40.82941000.414Contact Map0.818
3dmeA20.83181000.417Contact Map0.74
1y56B10.86491000.421Contact Map0.813
2gagB10.86021000.424Contact Map0.761
1pj5A10.91231000.429Contact Map0.74
3pvcA10.86261000.44Contact Map0.724
3ps9A10.85311000.442Contact Map0.751
2uzzA40.84361000.448Contact Map0.767
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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