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OPENSEQ.org
PEPB - Peptidase B
UniProt: P37095 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12310
Length: 427 (386)
Sequences: 1195
Seq/Len: 3.10
PEPB
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: AMPA PEPB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
321_F 374_A 3.647 1.00
265_Y 271_V 3.479 1.00
197_I 248_A 3.427 1.00
325_D 344_R 3.354 1.00
246_C 283_V 3.243 1.00
246_C 287_G 3.088 1.00
321_F 378_A 3.018 1.00
174_L 247_C 2.856 1.00
159_G 271_V 2.684 1.00
130_A 226_T 2.628 1.00
288_L 381_L 2.569 1.00
353_S 356_P 2.545 1.00
309_A 319_A 2.49 1.00
145_R 177_D 2.408 1.00
148_K 151_D 2.387 1.00
232_A 237_L 2.379 1.00
192_L 225_V 2.334 1.00
114_I 220_G 2.314 1.00
269_K 383_H 2.289 1.00
301_D 392_W 2.256 1.00
164_G 171_P 2.244 1.00
262_I 359_F 2.225 1.00
148_K 172_V 2.192 1.00
126_L 247_C 2.165 1.00
168_E 255_N 2.165 1.00
122_G 169_R 2.131 1.00
206_I 252_I 2.11 1.00
106_I 227_G 2.1 1.00
159_G 265_Y 2.057 1.00
126_L 222_A 2.05 1.00
232_A 241_V 2.018 1.00
352_R 383_H 1.999 1.00
317_Y 348_A 1.982 1.00
302_A 421_I 1.979 1.00
201_S 251_L 1.972 1.00
321_F 345_L 1.96 1.00
318_H 416_L 1.957 1.00
322_S 328_A 1.93 1.00
357_S 360_A 1.882 0.99
345_L 374_A 1.871 0.99
164_G 248_A 1.87 0.99
331_L 393_L 1.859 0.99
244_F 291_A 1.846 0.99
112_D 115_N 1.844 0.99
148_K 170_S 1.837 0.99
291_A 299_I 1.813 0.99
318_H 400_T 1.801 0.99
204_Y 252_I 1.773 0.99
358_N 411_A 1.767 0.99
264_T 270_K 1.759 0.99
159_G 263_I 1.754 0.99
174_L 245_L 1.719 0.99
328_A 344_R 1.712 0.99
136_N 230_A 1.705 0.99
274_M 365_T 1.703 0.98
157_Y 290_D 1.7 0.98
235_R 422_A 1.691 0.98
308_A 373_G 1.69 0.98
151_D 154_E 1.687 0.98
131_V 135_S 1.643 0.98
152_L 160_L 1.629 0.98
205_S 209_T 1.628 0.98
110_V 227_G 1.621 0.98
320_L 328_A 1.598 0.97
51_I 59_V 1.595 0.97
126_L 174_L 1.588 0.97
123_P 198_T 1.573 0.97
332_L 342_F 1.569 0.97
162_T 263_I 1.56 0.97
162_T 257_F 1.544 0.97
219_M 223_A 1.543 0.97
143_T 177_D 1.537 0.97
311_T 371_P 1.534 0.97
166_G 204_Y 1.531 0.96
168_E 253_S 1.531 0.96
311_T 370_Y 1.527 0.96
152_L 173_L 1.517 0.96
134_I 144_Y 1.504 0.96
355_L 365_T 1.501 0.96
173_L 287_G 1.473 0.95
149_G 171_P 1.471 0.95
320_L 395_I 1.452 0.95
196_G 222_A 1.45 0.95
274_M 363_N 1.447 0.95
318_H 395_I 1.413 0.94
124_S 169_R 1.408 0.94
129_R 132_D 1.407 0.94
180_P 240_R 1.396 0.93
415_G 418_V 1.389 0.93
105_M 234_T 1.381 0.93
165_R 255_N 1.362 0.92
121_L 125_Q 1.358 0.92
160_L 248_A 1.339 0.91
257_F 263_I 1.339 0.91
197_I 246_C 1.336 0.91
320_L 393_L 1.326 0.91
351_H 372_A 1.322 0.91
122_G 258_K 1.318 0.90
197_I 283_V 1.317 0.90
118_A 260_G 1.313 0.90
153_R 165_R 1.293 0.89
226_T 245_L 1.271 0.88
157_Y 266_R 1.264 0.88
232_A 425_L 1.263 0.88
175_A 242_K 1.262 0.88
269_K 362_L 1.258 0.87
225_V 243_L 1.246 0.87
208_Q 211_F 1.246 0.87
130_A 174_L 1.243 0.87
161_H 165_R 1.239 0.86
122_G 125_Q 1.239 0.86
205_S 212_M 1.233 0.86
213_D 274_M 1.218 0.85
263_I 273_V 1.208 0.84
110_V 224_T 1.205 0.84
229_L 232_A 1.205 0.84
175_A 290_D 1.204 0.84
149_G 164_G 1.201 0.84
332_L 344_R 1.197 0.84
243_L 302_A 1.194 0.83
134_I 176_L 1.194 0.83
116_A 121_L 1.193 0.83
230_A 234_T 1.191 0.83
160_L 173_L 1.187 0.83
310_K 371_P 1.185 0.83
156_G 266_R 1.184 0.83
362_L 383_H 1.183 0.83
153_R 161_H 1.176 0.82
127_A 146_I 1.174 0.82
107_I 419_R 1.173 0.82
309_A 345_L 1.155 0.81
205_S 274_M 1.137 0.79
164_G 249_D 1.135 0.79
248_A 283_V 1.135 0.79
169_R 258_K 1.134 0.79
257_F 273_V 1.131 0.79
224_T 418_V 1.129 0.78
206_I 209_T 1.127 0.78
123_P 249_D 1.125 0.78
373_G 376_T 1.116 0.77
191_C 299_I 1.11 0.77
127_A 131_V 1.107 0.77
266_R 289_I 1.106 0.76
137_V 230_A 1.102 0.76
166_G 252_I 1.102 0.76
327_L 393_L 1.102 0.76
225_V 302_A 1.102 0.76
106_I 110_V 1.099 0.76
126_L 144_Y 1.087 0.75
320_L 420_T 1.084 0.74
124_S 172_V 1.083 0.74
265_Y 380_F 1.075 0.74
351_H 375_S 1.074 0.73
176_L 226_T 1.073 0.73
292_S 386_E 1.071 0.73
251_L 258_K 1.07 0.73
342_F 420_T 1.07 0.73
334_S 423_N 1.061 0.72
222_A 245_L 1.059 0.72
147_T 155_Q 1.058 0.72
149_G 170_S 1.057 0.72
128_Q 132_D 1.057 0.72
324_D 389_Q 1.051 0.71
340_E 416_L 1.046 0.71
177_D 240_R 1.044 0.70
341_P 348_A 1.043 0.70
125_Q 129_R 1.042 0.70
310_K 374_A 1.029 0.69
114_I 399_A 1.029 0.69
176_L 229_L 1.026 0.69
265_Y 289_I 1.026 0.69
165_R 257_F 1.025 0.68
300_I 425_L 1.024 0.68
159_G 285_A 1.021 0.68
173_L 283_V 1.016 0.67
192_L 228_A 1.012 0.67
158_M 264_T 1.011 0.67
329_G 332_L 1.007 0.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3peiA10.96721000.15Contact Map0.77
3h8gF60.97191000.15Contact Map0.82
1gytA120.97191000.151Contact Map0.817
3jruB20.96961000.151Contact Map0.77
1lamA10.97661000.155Contact Map0.733
3kzwA120.97661000.161Contact Map0.774
4ksiA10.97191000.175Contact Map0.753
3kr4A120.96961000.183Contact Map0.81
3ij3A10.96251000.184Contact Map0.733
4efdA60.96491000.206Contact Map0.706
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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