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OPENSEQ.org

ZAPD - Cell division protein ZapD
UniProt: P36680 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12313
Length: 247 (247)
Sequences: 261
Seq/Len: 1.06

ZAPD
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
18_W 66_E 2.428 0.99
203_L 215_I 1.884 0.94
63_L 171_V 1.675 0.87
110_Q 230_D 1.622 0.85
17_T 53_V 1.578 0.83
7_F 21_I 1.577 0.83
48_S 118_I 1.556 0.82
1_M 4_Q 1.542 0.81
221_R 246_C 1.54 0.81
217_G 227_M 1.529 0.80
219_K 226_F 1.529 0.80
127_I 161_L 1.497 0.78
204_N 243_E 1.489 0.78
203_L 243_E 1.468 0.76
127_I 132_C 1.463 0.76
65_K 217_G 1.462 0.76
10_P 13_E 1.454 0.75
66_E 69_R 1.448 0.75
18_W 168_L 1.436 0.74
9_H 215_I 1.406 0.72
65_K 113_R 1.405 0.72
6_L 52_D 1.399 0.71
140_H 143_L 1.397 0.71
68_D 79_G 1.382 0.70
168_L 201_L 1.38 0.70
92_I 219_K 1.378 0.69
14_K 18_W 1.371 0.69
94_Q 173_D 1.368 0.69
68_D 174_L 1.362 0.68
18_W 125_L 1.333 0.66
74_L 81_P 1.33 0.65
54_F 59_V 1.327 0.65
127_I 136_L 1.31 0.64
109_G 112_L 1.307 0.63
226_F 242_F 1.288 0.62
61_T 96_K 1.288 0.62
14_K 50_L 1.286 0.62
8_E 13_E 1.285 0.62
181_F 245_A 1.267 0.60
191_Y 240_L 1.265 0.60
13_E 16_R 1.264 0.60
214_Q 232_E 1.262 0.59
48_S 119_A 1.256 0.59
190_F 221_R 1.252 0.59
127_I 178_S 1.247 0.58
12_N 17_T 1.247 0.58
36_D 191_Y 1.244 0.58
188_N 208_D 1.242 0.58
217_G 222_F 1.24 0.57
51_L 113_R 1.238 0.57
35_V 152_S 1.23 0.57
5_V 8_E 1.215 0.55
86_S 89_E 1.213 0.55
113_R 224_I 1.212 0.55
65_K 132_C 1.196 0.53
123_Q 221_R 1.192 0.53
62_E 175_I 1.177 0.52
64_L 99_G 1.172 0.51
95_L 170_M 1.171 0.51
199_D 214_Q 1.17 0.51
141_I 164_L 1.168 0.51
66_E 219_K 1.164 0.50
36_D 47_V 1.164 0.50
62_E 136_L 1.16 0.50
155_E 159_A 1.157 0.50
19_L 118_I 1.147 0.49
42_H 219_K 1.147 0.49
65_K 131_C 1.139 0.48
115_D 139_L 1.137 0.48
63_L 244_L 1.133 0.47
139_L 245_A 1.125 0.47
40_A 48_S 1.118 0.46
66_E 125_L 1.116 0.46
219_K 237_P 1.109 0.45
202_R 245_A 1.107 0.45
115_D 119_A 1.107 0.45
149_Q 152_S 1.105 0.45
161_L 166_Q 1.103 0.45
70_Q 217_G 1.101 0.44
41_L 44_F 1.1 0.44
190_F 212_Y 1.092 0.44
43_F 214_Q 1.089 0.43
21_I 75_Q 1.088 0.43
7_F 15_M 1.087 0.43
155_E 208_D 1.087 0.43
48_S 218_H 1.085 0.43
87_R 95_L 1.084 0.43
17_T 60_R 1.083 0.43
62_E 134_F 1.079 0.42
40_A 117_L 1.078 0.42
185_T 191_Y 1.077 0.42
67_L 73_K 1.076 0.42
39_G 146_P 1.073 0.42
10_P 16_R 1.071 0.42
59_V 138_T 1.071 0.42
94_Q 238_E 1.07 0.42
171_V 206_S 1.069 0.41
33_P 149_Q 1.067 0.41
27_Q 143_L 1.067 0.41
198_A 201_L 1.066 0.41
205_L 240_L 1.065 0.41
88_I 177_Q 1.06 0.41
135_D 192_Q 1.06 0.41
12_N 15_M 1.059 0.41
68_D 83_V 1.052 0.40
40_A 71_Q 1.051 0.40
26_Q 67_L 1.048 0.40
139_L 214_Q 1.046 0.39
75_Q 83_V 1.045 0.39
7_F 240_L 1.045 0.39
123_Q 143_L 1.045 0.39
185_T 241_D 1.043 0.39
16_R 20_R 1.04 0.39
114_E 155_E 1.039 0.39
160_S 217_G 1.039 0.39
86_S 104_S 1.038 0.39
60_R 239_R 1.034 0.38
84_D 221_R 1.034 0.38
33_P 90_A 1.031 0.38
58_E 99_G 1.029 0.38
49_E 82_G 1.028 0.38
44_F 116_R 1.025 0.37
18_W 55_E 1.021 0.37
62_E 124_R 1.021 0.37
162_N 241_D 1.02 0.37
78_I 145_L 1.019 0.37
47_V 120_L 1.018 0.37
43_F 196_G 1.018 0.37
17_T 23_F 1.014 0.37
19_L 161_L 1.013 0.36
206_S 209_S 1.01 0.36
21_I 58_E 1.009 0.36
143_L 226_F 1.005 0.36
41_L 71_Q 1.005 0.36
17_T 132_C 1.004 0.36
156_T 191_Y 1.002 0.35
174_L 202_R 1.001 0.35
201_L 215_I 1 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2oezA20.99191000.035Contact Map0.248
3gqbA20.408911.60.972Contact Map0.16
3o39A20.36449.10.973Contact Map0.142
1kbhB10.23087.90.974Contact Map0.506
3us6A10.53857.20.974Contact Map0.175
2lnmA10.23897.10.974Contact Map0.36
1zoqC20.18227.10.974Contact Map0.507
3vr4A30.433270.974Contact Map0.212
3atrA10.42516.60.975Contact Map0.029
1nafA10.43726.50.975Contact Map0.222

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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