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OPENSEQ.org
YEHB - Uncharacterized outer membrane usher protein YehB
UniProt: P33341 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11988
Length: 826 (786)
Sequences: 1341
Seq/Len: 1.71
YEHB
Paralog alert: 0.81 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ELFC FIMD HTRE SFMD YAGX YBGQ YEHB YFCU YHCD YQIG YRAJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
82_C 104_C 4.25 1.00
265_V 277_I 4.009 1.00
273_A 314_E 3.746 1.00
672_A 703_M 3.74 1.00
634_N 649_S 3.691 1.00
229_D 243_R 3.163 1.00
664_A 699_I 3.103 1.00
338_S 365_Y 3.026 1.00
242_F 358_F 2.922 1.00
751_W 791_N 2.898 1.00
769_V 797_V 2.786 1.00
274_L 313_K 2.785 1.00
662_N 693_N 2.76 1.00
311_S 319_V 2.744 1.00
795_P 813_F 2.718 1.00
636_S 647_G 2.699 1.00
500_G 525_Y 2.648 1.00
675_N 742_N 2.634 1.00
656_A 661_V 2.629 1.00
270_Q 318_S 2.573 1.00
313_K 319_V 2.545 1.00
338_S 363_Y 2.538 1.00
654_I 663_L 2.522 1.00
606_G 623_N 2.462 1.00
767_Y 799_V 2.427 1.00
769_V 786_L 2.42 1.00
608_N 621_G 2.387 1.00
657_W 662_N 2.383 1.00
270_Q 320_T 2.369 1.00
312_V 320_T 2.335 1.00
408_S 454_H 2.286 1.00
278_E 283_V 2.281 1.00
309_D 321_T 2.271 1.00
527_N 534_Y 2.229 0.99
755_A 811_I 2.221 0.99
160_L 178_V 2.206 0.99
673_V 697_V 2.2 0.99
188_G 216_R 2.189 0.99
61_Y 124_R 2.155 0.99
653_G 664_A 2.152 0.99
277_I 296_I 2.123 0.99
183_G 192_H 2.097 0.99
191_L 214_L 2.049 0.99
675_N 740_L 2.01 0.99
153_A 738_V 1.984 0.98
58_I 74_V 1.979 0.98
374_Y 402_D 1.977 0.98
151_I 673_V 1.951 0.98
342_L 361_A 1.945 0.98
577_N 589_N 1.929 0.98
141_Y 144_P 1.924 0.98
58_I 118_W 1.919 0.98
278_E 311_S 1.918 0.98
106_T 109_Q 1.904 0.98
503_S 524_S 1.903 0.98
402_D 422_Q 1.895 0.98
276_T 283_V 1.844 0.97
797_V 811_I 1.83 0.97
659_G 675_N 1.82 0.97
671_F 738_V 1.817 0.97
237_F 376_G 1.793 0.96
709_N 733_P 1.789 0.96
191_L 212_L 1.789 0.96
195_A 207_W 1.785 0.96
749_K 793_V 1.783 0.96
653_G 667_L 1.78 0.96
631_A 650_V 1.757 0.96
60_I 72_I 1.745 0.96
246_R 341_D 1.732 0.95
676_A 745_T 1.723 0.95
420_S 444_S 1.719 0.95
657_W 697_V 1.714 0.95
669_E 735_R 1.708 0.95
215_E 224_T 1.708 0.95
128_S 290_P 1.696 0.95
676_A 679_I 1.685 0.94
654_I 661_V 1.676 0.94
184_L 191_L 1.675 0.94
420_S 442_R 1.668 0.94
40_Q 44_I 1.661 0.94
633_V 650_V 1.661 0.94
94_N 97_N 1.659 0.94
117_T 126_D 1.625 0.93
312_V 322_Y 1.623 0.93
50_Q 81_T 1.619 0.93
276_T 313_K 1.615 0.93
755_A 786_L 1.586 0.92
226_R 248_F 1.583 0.92
658_S 740_L 1.573 0.91
667_L 671_F 1.569 0.91
537_A 553_N 1.568 0.91
252_Q 735_R 1.562 0.91
324_V 332_M 1.557 0.91
265_V 308_L 1.552 0.91
230_M 242_F 1.551 0.91
755_A 799_V 1.545 0.90
230_M 343_A 1.541 0.90
269_A 289_V 1.541 0.90
139_S 300_Q 1.531 0.90
763_L 799_V 1.528 0.90
420_S 512_W 1.513 0.89
251_M 339_K 1.512 0.89
540_Q 550_K 1.51 0.89
116_Y 127_F 1.507 0.89
251_M 337_V 1.499 0.89
653_G 699_I 1.498 0.89
733_P 739_V 1.496 0.88
218_F 221_L 1.495 0.88
190_Q 734_Y 1.495 0.88
82_C 332_M 1.489 0.88
672_A 711_L 1.488 0.88
152_N 184_L 1.484 0.88
55_Q 71_E 1.479 0.88
495_L 500_G 1.477 0.88
721_E 749_K 1.473 0.87
266_Q 295_A 1.458 0.87
149_R 219_A 1.448 0.86
217_G 224_T 1.445 0.86
405_K 419_Q 1.442 0.86
309_D 323_L 1.439 0.86
769_V 799_V 1.439 0.86
104_C 332_M 1.436 0.86
155_Y 671_F 1.43 0.85
628_A 631_A 1.424 0.85
653_G 671_F 1.416 0.84
486_S 509_R 1.414 0.84
434_T 443_Y 1.414 0.84
419_Q 445_S 1.412 0.84
57_D 71_E 1.412 0.84
757_R 763_L 1.41 0.84
526_S 535_T 1.4 0.84
366_G 397_G 1.398 0.83
262_T 334_Q 1.398 0.83
330_P 358_F 1.391 0.83
751_W 815_K 1.387 0.83
679_I 745_T 1.386 0.83
193_S 209_S 1.38 0.82
764_T 767_Y 1.377 0.82
152_N 738_V 1.377 0.82
242_F 343_A 1.376 0.82
160_L 176_T 1.375 0.82
385_A 404_T 1.374 0.82
655_V 671_F 1.368 0.82
84_S 87_V 1.368 0.82
238_D 450_T 1.36 0.81
576_S 592_G 1.359 0.81
698_V 701_D 1.358 0.81
755_A 763_L 1.357 0.81
152_N 658_S 1.351 0.80
708_E 730_I 1.35 0.80
529_L 534_Y 1.336 0.79
61_Y 66_W 1.33 0.79
256_N 707_R 1.329 0.79
156_T 182_S 1.324 0.79
162_Q 648_A 1.321 0.78
582_D 585_G 1.319 0.78
674_M 799_V 1.318 0.78
217_G 734_Y 1.317 0.78
276_T 286_Q 1.314 0.78
272_N 314_E 1.313 0.78
87_V 91_L 1.31 0.78
371_L 392_W 1.306 0.77
504_L 523_L 1.301 0.77
677_P 692_T 1.292 0.76
724_L 727_N 1.292 0.76
278_E 309_D 1.289 0.76
565_D 568_T 1.289 0.76
263_P 366_G 1.283 0.75
489_A 504_L 1.282 0.75
312_V 324_V 1.275 0.75
82_C 324_V 1.275 0.75
748_R 790_T 1.274 0.75
753_I 788_I 1.274 0.75
757_R 761_Q 1.273 0.75
185_N 192_H 1.27 0.74
508_W 519_K 1.262 0.74
243_R 348_H 1.26 0.74
682_A 692_T 1.26 0.74
216_R 225_L 1.258 0.73
119_D 126_D 1.255 0.73
367_F 752_F 1.252 0.73
684_V 700_Y 1.247 0.72
242_F 246_R 1.244 0.72
676_A 682_A 1.24 0.72
501_S 786_L 1.24 0.72
48_D 81_T 1.234 0.71
659_G 740_L 1.232 0.71
657_W 660_G 1.231 0.71
485_N 510_D 1.228 0.71
436_F 490_N 1.224 0.70
581_F 586_F 1.22 0.70
88_I 93_I 1.217 0.70
53_P 619_T 1.217 0.70
158_Y 652_G 1.211 0.69
655_V 738_V 1.211 0.69
692_T 750_P 1.21 0.69
226_R 230_M 1.209 0.69
432_T 493_Q 1.208 0.69
335_P 369_N 1.207 0.69
628_A 633_V 1.202 0.68
662_N 695_N 1.199 0.68
274_L 286_Q 1.194 0.68
159_Y 684_V 1.194 0.68
181_N 194_D 1.191 0.67
579_T 587_A 1.189 0.67
310_V 324_V 1.189 0.67
675_N 697_V 1.188 0.67
378_M 451_F 1.188 0.67
151_I 738_V 1.187 0.67
59_D 69_K 1.187 0.67
62_V 134_V 1.182 0.67
764_T 801_I 1.181 0.66
134_V 245_V 1.18 0.66
346_R 357_D 1.179 0.66
366_G 372_T 1.176 0.66
61_Y 126_D 1.174 0.66
655_V 673_V 1.173 0.66
151_I 658_S 1.171 0.66
273_A 316_D 1.17 0.65
129_V 277_I 1.169 0.65
193_S 212_L 1.168 0.65
665_N 689_Y 1.167 0.65
432_T 506_T 1.166 0.65
118_W 123_F 1.166 0.65
397_G 425_Y 1.165 0.65
88_I 448_Y 1.161 0.65
327_A 332_M 1.16 0.64
129_V 573_I 1.16 0.64
700_Y 711_L 1.158 0.64
311_S 321_T 1.158 0.64
755_A 780_V 1.157 0.64
508_W 517_S 1.156 0.64
677_P 695_N 1.156 0.64
693_N 699_I 1.148 0.63
796_S 810_T 1.144 0.63
374_Y 422_Q 1.142 0.63
734_Y 737_A 1.14 0.62
49_N 81_T 1.133 0.62
389_G 397_G 1.133 0.62
402_D 420_S 1.132 0.62
335_P 368_N 1.132 0.62
802_D 805_Q 1.127 0.61
771_D 775_H 1.126 0.61
217_G 706_Y 1.124 0.61
662_N 673_V 1.122 0.61
217_G 324_V 1.117 0.60
539_S 551_R 1.113 0.60
218_F 247_L 1.107 0.59
494_S 582_D 1.107 0.59
104_C 324_V 1.107 0.59
271_S 385_A 1.105 0.59
155_Y 738_V 1.103 0.59
294_F 314_E 1.101 0.58
111_V 114_G 1.101 0.58
490_N 555_F 1.096 0.58
127_F 173_N 1.096 0.58
154_F 184_L 1.094 0.58
624_L 635_G 1.09 0.57
291_P 585_G 1.089 0.57
408_S 535_T 1.088 0.57
154_F 656_A 1.085 0.57
667_L 738_V 1.081 0.56
223_G 340_Y 1.076 0.56
227_V 245_V 1.075 0.56
255_P 366_G 1.074 0.56
750_P 789_R 1.074 0.56
767_Y 801_I 1.071 0.55
55_Q 73_I 1.07 0.55
330_P 426_N 1.066 0.55
347_S 455_V 1.066 0.55
82_C 451_F 1.066 0.55
656_A 673_V 1.063 0.54
437_G 441_W 1.061 0.54
263_P 397_G 1.061 0.54
428_F 433_S 1.059 0.54
245_V 385_A 1.058 0.54
321_T 552_F 1.057 0.54
668_S 705_P 1.057 0.54
209_S 672_A 1.057 0.54
159_Y 207_W 1.056 0.54
111_V 133_W 1.055 0.54
133_W 293_P 1.055 0.54
136_E 297_T 1.055 0.54
484_K 512_W 1.054 0.53
657_W 673_V 1.054 0.53
446_R 711_L 1.053 0.53
420_S 439_A 1.052 0.53
64_K 630_V 1.052 0.53
404_T 420_S 1.051 0.53
610_S 619_T 1.051 0.53
232_T 640_S 1.049 0.53
748_R 787_F 1.048 0.53
207_W 788_I 1.046 0.53
662_N 697_V 1.045 0.53
250_D 735_R 1.045 0.53
59_D 62_V 1.044 0.52
149_R 188_G 1.044 0.52
81_T 394_T 1.043 0.52
394_T 682_A 1.042 0.52
223_G 249_R 1.041 0.52
238_D 374_Y 1.037 0.52
432_T 439_A 1.037 0.52
240_V 378_M 1.036 0.52
782_Q 789_R 1.034 0.51
123_F 333_L 1.032 0.51
795_P 815_K 1.031 0.51
674_M 684_V 1.031 0.51
82_C 670_T 1.03 0.51
182_S 193_S 1.03 0.51
420_S 441_W 1.029 0.51
439_A 489_A 1.028 0.51
147_W 732_A 1.027 0.51
209_S 229_D 1.025 0.50
424_A 437_G 1.023 0.50
535_T 555_F 1.023 0.50
364_Q 750_P 1.023 0.50
769_V 788_I 1.021 0.50
147_W 765_F 1.019 0.50
676_A 692_T 1.015 0.49
259_Q 358_F 1.015 0.49
597_V 605_Y 1.013 0.49
155_Y 653_G 1.012 0.49
768_E 776_N 1.012 0.49
627_N 665_N 1.012 0.49
796_S 812_T 1.012 0.49
134_V 290_P 1.011 0.49
175_S 227_V 1.011 0.49
98_F 133_W 1.01 0.49
156_T 661_V 1.009 0.49
794_P 814_G 1.008 0.49
802_D 807_L 1.005 0.48
243_R 360_Q 1.005 0.48
367_F 373_L 1.005 0.48
657_W 693_N 1.004 0.48
534_Y 554_I 1.002 0.48
150_G 279_Q 1.002 0.48
104_C 451_F 1.001 0.48
217_G 320_T 1 0.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rfzB20.95641000.104Contact Map0.7
3fipA20.57381000.47Contact Map0.726
3fcgA20.1091000.838Contact Map0.783
4b0mA10.148999.90.862Contact Map0.829
3bwuD10.139299.90.879Contact Map0.853
2xetA20.095699.60.908Contact Map0.856
3l48A50.098199.60.91Contact Map0.94
3e8vA10.088467.30.978Contact Map0.421
4kdwA10.13865.10.978Contact Map0.493
2pz4A10.214336.30.981Contact Map0.234
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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