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OPENSEQ.org
LLDP - L-lactate permease
UniProt: P33231 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11961
Length: 551 (547)
Sequences: 765
Seq/Len: 1.40
LLDP
Paralog alert: 0.34 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: GLCA LLDP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
516_K 519_D 3.205 1.00
442_F 446_S 3.059 1.00
541_L 545_V 2.624 1.00
180_A 468_A 2.422 1.00
403_K 406_A 2.397 1.00
52_A 56_L 2.35 0.99
488_A 539_T 2.333 0.99
27_F 49_I 2.332 0.99
264_L 268_R 2.314 0.99
237_A 257_V 2.283 0.99
537_V 541_L 2.182 0.99
532_T 536_G 2.177 0.99
55_L 65_A 2.167 0.99
448_F 532_T 2.159 0.99
30_F 35_L 2.139 0.99
124_C 258_S 1.948 0.97
51_L 65_A 1.94 0.97
229_V 265_F 1.936 0.97
533_C 537_V 1.891 0.96
177_I 195_V 1.891 0.96
381_L 385_V 1.861 0.96
73_F 413_G 1.856 0.96
399_G 403_K 1.825 0.95
51_L 421_I 1.818 0.95
384_I 394_A 1.805 0.95
10_P 17_S 1.797 0.95
97_T 389_M 1.795 0.95
383_S 387_L 1.776 0.94
260_L 264_L 1.725 0.93
378_F 382_L 1.723 0.93
390_K 393_D 1.709 0.93
96_K 400_S 1.707 0.93
395_I 399_G 1.704 0.93
111_T 116_L 1.697 0.93
241_S 253_I 1.672 0.92
180_A 486_V 1.67 0.92
30_F 34_K 1.668 0.92
27_F 31_A 1.656 0.91
468_A 486_V 1.602 0.89
300_L 304_T 1.595 0.89
53_V 57_F 1.594 0.89
92_K 404_E 1.593 0.89
11_A 57_F 1.591 0.89
312_T 378_F 1.586 0.89
448_F 536_G 1.584 0.89
321_F 324_L 1.578 0.88
338_I 366_F 1.577 0.88
451_W 528_S 1.54 0.87
37_L 41_V 1.536 0.87
379_A 383_S 1.525 0.86
62_V 66_L 1.507 0.85
391_P 395_I 1.488 0.84
165_T 498_M 1.481 0.84
48_A 381_L 1.481 0.84
529_L 533_C 1.474 0.83
4_W 8_Y 1.458 0.82
97_T 387_L 1.456 0.82
42_A 128_F 1.454 0.82
472_A 486_V 1.452 0.82
225_P 269_W 1.448 0.82
195_V 491_T 1.439 0.81
461_T 496_G 1.432 0.81
480_V 485_L 1.432 0.81
199_L 238_Q 1.431 0.81
47_V 69_V 1.42 0.80
56_L 62_V 1.415 0.80
215_D 219_G 1.412 0.80
222_E 273_R 1.404 0.79
205_I 530_I 1.395 0.78
122_G 163_V 1.394 0.78
157_A 470_L 1.394 0.78
206_V 531_F 1.386 0.78
158_G 523_F 1.386 0.78
197_R 243_N 1.385 0.78
180_A 191_I 1.38 0.77
227_V 232_G 1.379 0.77
117_Q 151_F 1.375 0.77
122_G 195_V 1.371 0.77
204_I 235_A 1.368 0.77
240_L 244_F 1.367 0.76
49_I 53_V 1.361 0.76
233_S 258_S 1.359 0.76
129_L 137_A 1.358 0.76
101_D 104_R 1.357 0.76
118_M 159_L 1.357 0.76
167_P 460_D 1.354 0.75
455_F 524_T 1.353 0.75
122_G 210_I 1.349 0.75
20_I 57_F 1.348 0.75
181_G 186_I 1.319 0.73
421_I 456_L 1.314 0.72
307_L 359_A 1.313 0.72
168_V 460_D 1.309 0.72
96_K 393_D 1.304 0.72
147_V 511_V 1.292 0.71
211_M 223_T 1.291 0.70
441_A 444_F 1.291 0.70
19_L 221_K 1.289 0.70
321_F 479_G 1.288 0.70
321_F 325_F 1.27 0.69
110_I 265_F 1.263 0.68
233_S 257_V 1.26 0.68
162_I 213_I 1.259 0.68
127_A 454_V 1.254 0.67
106_S 303_W 1.244 0.66
311_A 378_F 1.243 0.66
253_I 257_V 1.24 0.66
412_I 503_S 1.238 0.66
122_G 126_G 1.238 0.66
381_L 421_I 1.237 0.66
419_A 501_P 1.236 0.66
491_T 542_Q 1.231 0.65
198_Q 542_Q 1.231 0.65
27_F 46_T 1.229 0.65
497_K 503_S 1.229 0.65
422_S 428_S 1.227 0.65
460_D 493_G 1.226 0.65
165_T 460_D 1.226 0.65
392_S 395_I 1.226 0.65
10_P 21_A 1.225 0.65
500_S 505_A 1.222 0.64
226_A 265_F 1.22 0.64
116_L 226_A 1.212 0.63
26_L 228_V 1.208 0.63
20_I 23_L 1.208 0.63
137_A 518_S 1.208 0.63
29_F 521_F 1.204 0.63
18_S 434_A 1.204 0.63
75_Y 420_F 1.202 0.62
325_F 331_L 1.202 0.62
208_F 227_V 1.19 0.61
265_F 269_W 1.189 0.61
228_V 385_V 1.178 0.60
392_S 396_S 1.177 0.60
90_V 380_A 1.177 0.60
48_A 51_L 1.175 0.60
504_I 521_F 1.175 0.60
498_M 513_L 1.173 0.60
96_K 396_S 1.171 0.59
501_P 505_A 1.171 0.59
83_I 90_V 1.169 0.59
169_A 195_V 1.162 0.59
236_I 240_L 1.161 0.58
191_I 486_V 1.159 0.58
460_D 491_T 1.157 0.58
204_I 231_G 1.156 0.58
506_I 527_H 1.151 0.57
157_A 507_A 1.149 0.57
297_G 301_R 1.148 0.57
237_A 254_S 1.148 0.57
104_R 145_L 1.146 0.57
103_I 303_W 1.145 0.57
468_A 472_A 1.142 0.57
304_T 386_W 1.137 0.56
227_V 231_G 1.137 0.56
126_G 163_V 1.136 0.56
206_V 550_I 1.133 0.56
225_P 271_P 1.132 0.56
122_G 231_G 1.129 0.55
184_T 255_S 1.125 0.55
93_I 438_T 1.124 0.55
53_V 56_L 1.124 0.55
166_A 251_D 1.123 0.55
411_S 432_A 1.121 0.54
438_T 441_A 1.12 0.54
49_I 154_L 1.12 0.54
423_N 462_S 1.119 0.54
233_S 237_A 1.118 0.54
542_Q 549_M 1.114 0.54
238_Q 494_V 1.112 0.54
388_K 393_D 1.111 0.53
209_W 445_F 1.11 0.53
69_V 421_I 1.11 0.53
44_S 414_M 1.109 0.53
197_R 200_P 1.109 0.53
81_A 409_I 1.109 0.53
82_W 177_I 1.108 0.53
475_A 498_M 1.107 0.53
279_D 282_A 1.107 0.53
117_Q 149_L 1.106 0.53
62_V 537_V 1.104 0.53
169_A 460_D 1.104 0.53
44_S 410_Y 1.103 0.53
495_T 531_F 1.103 0.53
23_L 49_I 1.101 0.52
93_I 129_L 1.1 0.52
29_F 421_I 1.098 0.52
26_L 445_F 1.098 0.52
205_I 366_F 1.096 0.52
28_F 145_L 1.095 0.52
215_D 220_I 1.095 0.52
36_K 519_D 1.094 0.52
26_L 336_I 1.092 0.51
58_Y 303_W 1.088 0.51
526_K 530_I 1.085 0.51
126_G 165_T 1.084 0.51
475_A 480_V 1.083 0.51
205_I 208_F 1.08 0.50
47_V 133_A 1.078 0.50
25_I 131_G 1.078 0.50
238_Q 460_D 1.078 0.50
350_M 357_A 1.073 0.50
188_S 192_G 1.07 0.49
47_V 421_I 1.069 0.49
110_I 120_I 1.065 0.49
197_R 239_Y 1.065 0.49
169_A 238_Q 1.064 0.49
497_K 502_Q 1.062 0.48
174_G 246_G 1.062 0.48
62_V 410_Y 1.062 0.48
494_V 502_Q 1.061 0.48
301_R 304_T 1.059 0.48
489_N 497_K 1.058 0.48
358_T 361_A 1.056 0.48
261_C 401_T 1.056 0.48
172_A 177_I 1.056 0.48
70_V 385_V 1.052 0.47
447_P 501_P 1.052 0.47
95_V 101_D 1.051 0.47
61_P 224_W 1.05 0.47
128_F 160_C 1.05 0.47
48_A 190_E 1.05 0.47
193_Q 243_N 1.05 0.47
295_T 298_Q 1.046 0.47
194_M 483_L 1.044 0.47
128_F 376_I 1.042 0.46
186_I 486_V 1.042 0.46
40_Y 407_L 1.04 0.46
56_L 381_L 1.039 0.46
316_W 375_A 1.036 0.46
497_K 506_I 1.034 0.46
83_I 135_F 1.034 0.46
9_D 13_N 1.032 0.45
16_L 22_S 1.032 0.45
46_T 84_I 1.031 0.45
128_F 132_A 1.031 0.45
83_I 172_A 1.029 0.45
225_P 229_V 1.022 0.44
119_L 262_L 1.022 0.44
218_R 240_L 1.021 0.44
201_F 240_L 1.02 0.44
339_P 344_D 1.02 0.44
294_Y 298_Q 1.02 0.44
177_I 464_N 1.02 0.44
45_W 469_A 1.018 0.44
449_L 470_L 1.015 0.44
343_L 432_A 1.013 0.44
163_V 210_I 1.012 0.43
30_F 291_H 1.012 0.43
179_V 431_L 1.012 0.43
120_I 263_T 1.011 0.43
114_Q 151_F 1.011 0.43
216_G 219_G 1.011 0.43
529_L 540_T 1.01 0.43
26_L 386_W 1.01 0.43
184_T 486_V 1.009 0.43
316_W 428_S 1.008 0.43
196_G 251_D 1.008 0.43
304_T 307_L 1.008 0.43
25_I 455_F 1.005 0.43
131_G 492_G 1.005 0.43
26_L 284_Q 1.003 0.43
128_F 247_P 1.002 0.42
31_A 37_L 1.002 0.42
159_L 529_L 1.002 0.42
110_I 301_R 1.001 0.42
442_F 500_S 1 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.744199.40.907Contact Map0.326
1v76A20.08536.50.985Contact Map0.084
2loqA10.17424.10.986Contact Map0.053
2l6wA20.05632.20.988Contact Map0.017
3aqpA20.30492.10.988Contact Map0.19
4jc9S140.08711.80.988Contact Map0.749
2lbgA10.0491.70.988Contact Map1
1jb0B10.17421.70.989Contact Map0.171
4g1uA20.43381.50.989Contact Map0.116
2lzlA20.0781.20.989Contact Map0.64
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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