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PURT - Phosphoribosylglycinamide formyltransferase 2
UniProt: P33221 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11809
Length: 392 (381)
Sequences: 10428
Seq/Len: 27.37
PURT
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: ACCC DDLA DDLB GSHB PUR2 PURK PURT RIMK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
146_A 171_A 4.638 1.00
170_S 173_Q 3.59 1.00
252_R 256_L 3.306 1.00
92_I 109_K 3.247 1.00
137_S 140_L 3.206 1.00
142_R 175_A 3.15 1.00
14_R 37_E 3.123 1.00
69_R 73_L 3.075 1.00
131_T 196_G 3.017 1.00
92_I 96_E 2.929 1.00
124_E 257_A 2.904 1.00
249_E 253_K 2.856 1.00
241_P 245_E 2.821 1.00
246_R 249_E 2.717 1.00
371_A 376_D 2.652 1.00
150_Y 171_A 2.647 1.00
13_T 77_H 2.604 1.00
373_S 376_D 2.553 1.00
63_D 66_A 2.541 1.00
133_R 147_D 2.461 1.00
15_V 101_V 2.378 1.00
240_S 243_A 2.367 1.00
271_C 274_E 2.36 1.00
72_E 97_E 2.328 1.00
246_R 274_E 2.293 1.00
169_R 173_Q 2.289 1.00
305_R 310_L 2.234 1.00
121_A 254_V 2.201 1.00
169_R 199_K 2.137 1.00
143_E 147_D 2.135 1.00
119_R 124_E 2.105 1.00
372_E 376_D 2.067 1.00
245_E 249_E 2.028 1.00
33_R 301_A 1.998 1.00
93_Q 97_E 1.985 1.00
175_A 179_K 1.985 1.00
57_H 70_V 1.879 1.00
206_L 247_A 1.845 1.00
171_A 175_A 1.84 1.00
142_R 171_A 1.823 1.00
37_E 55_R 1.813 1.00
116_G 119_R 1.808 1.00
245_E 248_Q 1.802 1.00
212_V 261_Y 1.8 1.00
68_R 97_E 1.791 1.00
182_Q 190_G 1.779 1.00
57_H 74_E 1.775 1.00
235_Q 294_S 1.77 1.00
136_D 140_L 1.755 1.00
250_I 275_V 1.749 1.00
324_A 381_A 1.739 1.00
302_L 313_G 1.724 1.00
109_K 116_G 1.709 1.00
95_E 105_A 1.696 1.00
186_R 190_G 1.695 1.00
64_G 93_Q 1.689 1.00
167_F 197_V 1.664 1.00
64_G 68_R 1.663 1.00
17_L 28_A 1.655 1.00
144_A 147_D 1.647 1.00
143_E 146_A 1.637 1.00
284_P 299_E 1.634 1.00
15_V 31_C 1.624 1.00
120_L 257_A 1.621 1.00
301_A 305_R 1.615 1.00
253_K 256_L 1.606 1.00
30_E 301_A 1.599 1.00
68_R 72_E 1.598 1.00
139_S 143_E 1.596 1.00
104_C 107_A 1.582 1.00
32_Q 54_H 1.574 1.00
14_R 39_I 1.558 1.00
65_D 93_Q 1.545 1.00
79_I 99_L 1.535 1.00
243_A 246_R 1.512 1.00
140_L 143_E 1.512 1.00
208_T 251_A 1.502 1.00
15_V 36_V 1.492 1.00
94_L 99_L 1.492 1.00
31_C 38_V 1.491 1.00
327_L 362_R 1.486 1.00
16_M 41_V 1.474 1.00
104_C 261_Y 1.472 1.00
196_G 276_I 1.472 1.00
111_T 280_V 1.465 1.00
144_A 148_I 1.461 1.00
119_R 123_E 1.46 1.00
138_E 142_R 1.46 1.00
120_L 125_L 1.458 1.00
71_V 99_L 1.452 1.00
157_V 191_R 1.449 1.00
66_A 69_R 1.444 1.00
71_V 79_I 1.441 1.00
209_V 306_A 1.44 1.00
348_L 369_A 1.435 1.00
121_A 277_F 1.431 1.00
93_Q 96_E 1.426 1.00
14_R 55_R 1.423 1.00
248_Q 252_R 1.42 1.00
115_E 119_R 1.419 1.00
94_L 100_N 1.406 0.99
40_A 49_A 1.388 0.99
110_L 120_L 1.382 0.99
142_R 146_A 1.361 0.99
215_V 256_L 1.359 0.99
69_R 72_E 1.35 0.99
135_A 144_A 1.344 0.99
242_L 246_R 1.34 0.99
127_L 277_F 1.338 0.99
50_M 56_S 1.335 0.99
375_V 379_E 1.331 0.99
92_I 106_R 1.329 0.99
152_C 194_V 1.324 0.99
115_E 134_F 1.295 0.99
209_V 302_L 1.293 0.99
243_A 270_V 1.291 0.99
145_V 150_Y 1.29 0.99
217_F 314_G 1.289 0.99
139_S 142_R 1.287 0.99
150_Y 170_S 1.284 0.99
210_S 216_H 1.283 0.99
138_E 175_A 1.28 0.99
209_V 263_L 1.277 0.99
131_T 147_D 1.26 0.99
383_H 387_Q 1.259 0.99
55_R 74_E 1.259 0.99
70_V 74_E 1.255 0.99
239_M 243_A 1.253 0.99
133_R 144_A 1.248 0.99
296_D 316_R 1.244 0.98
16_M 71_V 1.241 0.98
36_V 308_L 1.225 0.98
106_R 110_L 1.224 0.98
206_L 251_A 1.22 0.98
125_L 257_A 1.22 0.98
176_Q 180_Y 1.214 0.98
138_E 179_K 1.213 0.98
119_R 132_Y 1.2 0.98
150_Y 174_L 1.188 0.98
113_N 157_V 1.186 0.98
138_E 178_W 1.185 0.98
79_I 94_L 1.181 0.98
340_V 357_E 1.181 0.98
208_T 255_V 1.179 0.98
371_A 380_R 1.173 0.98
120_L 124_E 1.169 0.97
30_E 33_R 1.168 0.97
199_K 272_G 1.163 0.97
15_V 304_V 1.159 0.97
145_V 174_L 1.152 0.97
141_F 178_W 1.147 0.97
128_P 250_I 1.145 0.97
123_E 131_T 1.145 0.97
95_E 104_C 1.143 0.97
154_V 192_V 1.142 0.97
41_V 59_I 1.133 0.97
324_A 365_G 1.131 0.97
296_D 318_Y 1.129 0.97
367_A 388_V 1.127 0.97
27_V 80_V 1.124 0.97
40_A 53_A 1.121 0.97
28_A 52_V 1.12 0.96
172_E 176_Q 1.115 0.96
293_I 368_L 1.115 0.96
117_I 121_A 1.114 0.96
110_L 116_G 1.109 0.96
292_L 368_L 1.109 0.96
70_V 76_P 1.108 0.96
254_V 280_V 1.105 0.96
168_I 177_A 1.097 0.96
204_I 270_V 1.097 0.96
92_I 105_A 1.097 0.96
95_E 261_Y 1.092 0.96
153_I 167_F 1.092 0.96
71_V 94_L 1.088 0.96
134_F 191_R 1.085 0.96
251_A 266_V 1.083 0.96
376_D 380_R 1.075 0.95
123_E 129_T 1.073 0.95
106_R 109_K 1.062 0.95
176_Q 179_K 1.062 0.95
25_K 52_V 1.059 0.95
136_D 191_R 1.058 0.95
42_D 56_S 1.053 0.95
166_T 184_G 1.053 0.95
240_S 273_D 1.044 0.94
178_W 192_V 1.043 0.94
322_A 377_A 1.041 0.94
242_L 245_E 1.038 0.94
118_R 195_E 1.038 0.94
140_L 144_A 1.037 0.94
293_I 370_T 1.035 0.94
118_R 129_T 1.029 0.94
101_V 304_V 1.027 0.94
104_C 259_G 1.026 0.94
220_P 317_Q 1.017 0.93
341_Q 352_L 1.015 0.93
353_F 356_P 1.013 0.93
141_F 174_L 1.01 0.93
311_P 314_G 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1kjqA20.99491000.215Contact Map0.766
2dwcA20.99491000.246Contact Map0.763
4e4tA20.96941000.28Contact Map0.614
3ax6A40.92861000.284Contact Map0.799
4mamA20.91331000.291Contact Map0.681
3q2oA20.95661000.293Contact Map0.657
3aw8A20.91841000.293Contact Map0.692
3orqA20.93621000.305Contact Map0.675
4dimA10.96171000.306Contact Map0.639
3k5iA40.96171000.316Contact Map0.719
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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