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YEIR - Uncharacterized protein YeiR
UniProt: P33030 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12104
Length: 328 (324)
Sequences: 2582
Seq/Len: 7.97
YEIR
Paralog alert: 0.63 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: YEIR YJIA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
166_Q 180_H 5.587 1.00
312_W 316_Q 5.103 1.00
150_V 181_S 4.303 1.00
158_T 161_S 3.826 1.00
125_P 157_T 3.495 1.00
245_F 320_L 3.04 1.00
155_D 182_E 2.995 1.00
149_I 169_W 2.924 1.00
152_N 181_S 2.788 1.00
7_I 19_I 2.746 1.00
166_Q 170_Q 2.59 1.00
177_Q 190_L 2.478 1.00
259_W 318_A 2.373 1.00
22_L 89_L 2.368 1.00
88_L 114_I 2.225 1.00
311_D 314_A 2.223 1.00
21_H 185_K 2.181 1.00
122_I 152_N 2.062 1.00
165_L 169_W 2.061 1.00
125_P 151_A 2.044 1.00
268_V 281_I 1.989 1.00
5_N 117_R 1.982 1.00
30_E 87_R 1.966 1.00
173_G 176_R 1.95 1.00
157_T 162_E 1.905 1.00
252_D 255_G 1.872 1.00
8_T 121_C 1.862 1.00
302_I 305_I 1.848 1.00
316_Q 320_L 1.801 1.00
162_E 166_Q 1.779 1.00
161_S 164_A 1.772 1.00
154_S 162_E 1.755 1.00
303_E 306_S 1.737 1.00
21_H 25_H 1.737 1.00
38_E 43_G 1.725 1.00
181_S 184_G 1.721 1.00
256_I 274_I 1.703 1.00
118_A 148_I 1.701 1.00
243_W 315_L 1.68 1.00
154_S 180_H 1.666 1.00
76_L 88_L 1.649 1.00
22_L 188_G 1.638 1.00
33_A 79_L 1.619 1.00
18_S 184_G 1.613 1.00
43_G 46_G 1.608 1.00
159_P 163_Q 1.592 1.00
31_K 86_D 1.591 1.00
43_G 58_E 1.591 1.00
63_C 66_C 1.559 1.00
23_L 34_V 1.548 1.00
30_E 189_H 1.545 1.00
162_E 180_H 1.535 1.00
222_L 226_Q 1.529 1.00
170_Q 178_L 1.523 1.00
148_I 177_Q 1.519 1.00
77_N 81_R 1.511 1.00
163_Q 167_R 1.503 1.00
8_T 119_T 1.501 1.00
254_I 258_E 1.472 0.99
128_L 143_L 1.469 0.99
25_H 28_P 1.465 0.99
250_V 273_R 1.462 0.99
182_E 185_K 1.449 0.99
92_P 96_G 1.43 0.99
313_N 317_S 1.428 0.99
177_Q 196_R 1.423 0.99
146_A 173_G 1.382 0.99
38_E 46_G 1.373 0.99
42_V 244_I 1.371 0.99
152_N 183_H 1.364 0.99
13_S 122_I 1.362 0.99
18_S 122_I 1.362 0.99
163_Q 166_Q 1.34 0.99
93_T 96_G 1.338 0.99
125_P 162_E 1.336 0.99
12_G 15_K 1.325 0.99
121_C 146_A 1.314 0.98
194_P 197_N 1.31 0.98
78_T 82_Q 1.304 0.98
2_T 88_L 1.301 0.98
224_E 231_S 1.294 0.98
143_L 149_I 1.276 0.98
36_V 44_I 1.273 0.98
21_H 184_G 1.271 0.98
245_F 251_F 1.264 0.98
64_M 90_I 1.251 0.98
283_R 288_L 1.251 0.98
300_S 305_I 1.249 0.98
146_A 149_I 1.243 0.97
183_H 289_H 1.242 0.97
11_L 14_G 1.239 0.97
150_V 179_I 1.236 0.97
80_L 114_I 1.23 0.97
314_A 318_A 1.222 0.97
143_L 169_W 1.221 0.97
120_L 313_N 1.218 0.97
102_L 119_T 1.202 0.97
11_L 15_K 1.201 0.97
80_L 88_L 1.2 0.97
124_D 153_K 1.198 0.97
313_N 316_Q 1.181 0.96
317_S 321_K 1.174 0.96
97_H 141_D 1.169 0.96
125_P 169_W 1.164 0.96
320_L 323_R 1.157 0.96
32_W 87_R 1.155 0.96
102_L 116_L 1.153 0.96
12_G 16_T 1.139 0.95
278_L 293_Q 1.123 0.95
273_R 296_A 1.117 0.95
302_I 306_S 1.114 0.94
20_L 40_G 1.11 0.94
152_N 184_G 1.108 0.94
11_L 37_N 1.106 0.94
166_Q 178_L 1.106 0.94
5_N 87_R 1.105 0.94
253_T 257_L 1.099 0.94
257_L 261_R 1.097 0.94
150_V 180_H 1.086 0.93
6_L 105_L 1.086 0.93
155_D 183_H 1.085 0.93
272_L 300_S 1.082 0.93
9_G 12_G 1.081 0.93
148_I 179_I 1.079 0.93
22_L 32_W 1.078 0.93
251_F 323_R 1.077 0.93
43_G 60_P 1.071 0.93
157_T 165_L 1.071 0.93
14_G 17_T 1.068 0.93
167_R 171_Q 1.067 0.93
1_M 115_D 1.06 0.92
39_F 96_G 1.059 0.92
306_S 310_A 1.055 0.92
314_A 317_S 1.055 0.92
179_I 186_V 1.047 0.92
210_Q 213_V 1.039 0.91
163_Q 180_H 1.029 0.91
128_L 165_L 1.025 0.90
11_L 16_T 1.025 0.90
5_N 147_D 1.021 0.90
76_L 114_I 1.019 0.90
247_A 316_Q 1.014 0.90
70_L 74_V 1.014 0.90
151_A 166_Q 1.007 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1nijA10.91161000.403Contact Map0.545
2wsmA20.576299.90.736Contact Map0.626
2hf9A20.567199.90.747Contact Map0.645
4hi0E20.567199.80.762Contact Map0.622
1yrbA20.676899.80.774Contact Map0.509
1xjcA10.466599.80.776Contact Map0.316
2qm8A20.670799.70.801Contact Map0.454
2wwwA40.762299.50.82Contact Map0.561
2p67A10.655599.40.829Contact Map0.574
3p32A10.768399.20.849Contact Map0.548
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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