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OPENSEQ.org
DACD - D-alanyl-D-alanine carboxypeptidase DacD
UniProt: P33013 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11893
Length: 388 (362)
Sequences: 1600
Seq/Len: 4.42
DACD
Paralog alert: 0.49 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: DACA DACC DACD PBP7
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
56_H 182_Y 4.212 1.00
41_L 278_G 3.354 1.00
118_V 137_L 3.295 1.00
91_G 139_D 3.096 1.00
254_L 278_G 2.996 1.00
52_A 55_E 2.957 1.00
188_S 231_L 2.761 1.00
73_V 137_L 2.738 1.00
87_I 115_R 2.722 1.00
124_G 130_G 2.699 1.00
229_D 253_R 2.616 1.00
117_S 120_D 2.603 1.00
145_Q 169_V 2.557 1.00
56_H 163_D 2.509 1.00
161_L 187_L 2.465 1.00
125_L 134_C 2.457 1.00
54_N 57_Q 2.454 1.00
125_L 137_L 2.441 1.00
142_A 151_M 2.432 1.00
58_Q 178_H 2.406 1.00
350_E 362_H 2.404 1.00
248_V 251_Q 2.385 1.00
338_L 348_V 2.319 1.00
71_Y 190_A 2.311 1.00
123_R 204_E 2.305 1.00
86_D 140_Y 2.267 1.00
304_K 369_E 2.214 1.00
144_G 147_Q 2.14 1.00
342_I 367_T 2.128 1.00
188_S 244_I 2.094 1.00
159_L 190_A 2.091 1.00
155_Y 158_K 2.08 1.00
87_I 117_S 2.06 1.00
41_L 254_L 2.049 1.00
92_R 112_E 2.042 1.00
310_G 368_L 2.019 1.00
343_S 370_S 1.967 1.00
67_L 244_I 1.941 1.00
85_D 119_R 1.9 1.00
286_Q 289_H 1.889 1.00
39_W 51_T 1.883 1.00
227_N 249_D 1.858 1.00
256_A 271_A 1.808 1.00
347_R 364_P 1.806 1.00
44_Y 255_I 1.791 1.00
229_D 246_S 1.787 1.00
142_A 147_Q 1.779 1.00
38_S 181_A 1.768 1.00
68_M 164_T 1.764 1.00
247_A 279_Q 1.753 1.00
245_A 271_A 1.732 0.99
147_Q 150_E 1.722 0.99
270_E 273_K 1.699 0.99
182_Y 186_V 1.678 0.99
70_G 125_L 1.675 0.99
75_R 155_Y 1.675 0.99
184_L 244_I 1.66 0.99
88_V 136_A 1.643 0.99
181_A 259_M 1.64 0.99
165_H 178_H 1.63 0.99
150_E 154_N 1.618 0.99
64_L 184_L 1.611 0.99
58_Q 163_D 1.599 0.99
73_V 125_L 1.586 0.99
43_D 252_R 1.586 0.99
348_V 367_T 1.583 0.99
89_T 115_R 1.58 0.99
88_V 140_Y 1.575 0.99
296_T 306_N 1.568 0.99
347_R 350_E 1.563 0.99
359_Q 362_H 1.55 0.98
38_S 59_R 1.527 0.98
90_V 136_A 1.524 0.98
68_M 156_A 1.522 0.98
93_D 139_D 1.515 0.98
352_E 362_H 1.513 0.98
189_R 255_I 1.499 0.98
69_T 134_C 1.496 0.98
346_Q 367_T 1.494 0.98
173_D 238_G 1.485 0.98
164_T 179_S 1.476 0.98
236_T 239_A 1.466 0.98
354_Y 359_Q 1.451 0.97
161_L 186_V 1.44 0.97
192_I 199_Y 1.433 0.97
119_R 123_R 1.424 0.97
61_P 179_S 1.422 0.97
331_Y 365_L 1.418 0.97
190_A 194_G 1.408 0.97
91_G 94_A 1.405 0.97
64_L 244_I 1.402 0.97
239_A 242_N 1.401 0.97
76_A 81_R 1.394 0.97
123_R 127_V 1.388 0.96
84_P 122_S 1.386 0.96
199_Y 246_S 1.381 0.96
124_G 133_A 1.371 0.96
83_T 86_D 1.37 0.96
40_V 182_Y 1.349 0.96
154_N 158_K 1.341 0.95
299_I 302_G 1.339 0.95
71_Y 155_Y 1.337 0.95
129_S 233_T 1.326 0.95
343_S 346_Q 1.324 0.95
84_P 119_R 1.323 0.95
352_E 359_Q 1.323 0.95
246_S 253_R 1.315 0.95
67_L 191_I 1.314 0.95
70_G 122_S 1.313 0.95
129_S 232_K 1.307 0.94
197_E 200_H 1.305 0.94
64_L 259_M 1.301 0.94
167_E 174_A 1.3 0.94
67_L 231_L 1.286 0.94
70_G 126_I 1.279 0.94
134_C 169_V 1.278 0.94
71_Y 194_G 1.271 0.93
60_N 173_D 1.263 0.93
73_V 82_I 1.263 0.93
344_A 370_S 1.262 0.93
65_T 177_Q 1.26 0.93
228_V 245_A 1.252 0.93
108_M 124_G 1.244 0.92
286_Q 316_W 1.24 0.92
205_K 222_W 1.239 0.92
40_V 55_E 1.231 0.92
288_L 311_T 1.225 0.92
38_S 54_N 1.224 0.92
82_I 140_Y 1.219 0.91
39_W 53_G 1.215 0.91
330_K 354_Y 1.213 0.91
58_Q 180_S 1.209 0.91
374_G 378_S 1.208 0.91
307_I 367_T 1.207 0.91
77_I 198_F 1.202 0.91
354_Y 357_D 1.201 0.91
299_I 340_A 1.189 0.90
92_R 96_A 1.179 0.89
303_D 372_G 1.172 0.89
62_A 239_A 1.171 0.89
78_D 197_E 1.165 0.89
243_L 271_A 1.164 0.89
167_E 176_G 1.161 0.88
290_R 314_E 1.151 0.88
297_E 309_L 1.151 0.88
60_N 238_G 1.142 0.87
90_V 110_L 1.142 0.87
323_E 326_H 1.139 0.87
130_G 133_A 1.137 0.87
162_K 182_Y 1.127 0.86
38_S 259_M 1.125 0.86
200_H 203_S 1.118 0.86
41_L 256_A 1.116 0.86
277_W 282_F 1.112 0.85
308_D 368_L 1.105 0.85
289_H 314_E 1.104 0.85
67_L 188_S 1.1 0.85
245_A 256_A 1.096 0.84
245_A 275_L 1.083 0.83
302_G 340_A 1.082 0.83
289_H 292_K 1.07 0.82
315_F 361_A 1.069 0.82
307_I 371_V 1.069 0.82
272_R 276_R 1.059 0.81
159_L 187_L 1.059 0.81
47_G 189_R 1.059 0.81
367_T 370_S 1.057 0.81
127_V 204_E 1.056 0.81
258_V 271_A 1.056 0.81
263_S 266_G 1.054 0.81
373_E 379_R 1.05 0.81
312_E 364_P 1.041 0.80
155_Y 190_A 1.039 0.80
42_M 186_V 1.025 0.78
73_V 118_V 1.022 0.78
72_V 76_A 1.01 0.77
156_A 166_F 1.01 0.77
375_S 378_S 1.008 0.77
119_R 200_H 1.004 0.76
90_V 121_L 1.002 0.76
77_I 82_I 1.001 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3mzfA10.93561000.236Contact Map0.844
4k91A20.89181000.249Contact Map0.857
3itaA40.90721000.25Contact Map0.844
3a3jA10.88141000.265Contact Map0.84
1xp4A40.89431000.269Contact Map0.852
3mfdA20.84281000.293Contact Map0.811
3hunA20.93811000.359Contact Map0.844
1tvfA20.85821000.391Contact Map0.848
2bcfA10.68561000.491Contact Map0.752
1es5A10.6341000.507Contact Map0.828
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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