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OPENSEQ.org
SBMC - DNA gyrase inhibitor
UniProt: P33012 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11892
Length: 157 (154)
Sequences: 1337
Seq/Len: 8.68
SBMC
Paralog alert: 0.53 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: SBMC YGIV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
124_E 153_Q 3.079 1.00
12_T 86_L 2.763 1.00
99_A 109_P 2.509 1.00
10_K 88_E 2.497 1.00
10_K 91_G 2.382 1.00
98_V 147_E 2.287 1.00
13_V 68_V 2.028 1.00
11_R 89_I 1.988 1.00
53_D 64_R 1.944 1.00
117_L 121_S 1.936 1.00
49_A 65_C 1.91 1.00
118_L 121_S 1.86 1.00
95_A 117_L 1.802 1.00
92_G 126_L 1.752 1.00
17_H 64_R 1.726 1.00
51_Y 65_C 1.719 1.00
97_A 113_F 1.684 1.00
110_W 148_M 1.63 1.00
16_F 29_G 1.622 1.00
93_Q 123_Y 1.592 1.00
4_E 96_V 1.555 1.00
6_K 96_V 1.54 1.00
5_I 95_A 1.495 1.00
7_Q 93_Q 1.495 1.00
29_G 33_L 1.462 0.99
12_T 88_E 1.46 0.99
49_A 67_T 1.452 0.99
128_K 151_A 1.451 0.99
36_W 84_V 1.419 0.99
6_K 149_Y 1.415 0.99
30_F 67_T 1.402 0.99
94_Y 131_F 1.401 0.99
29_G 67_T 1.396 0.99
100_R 145_D 1.375 0.99
52_Y 66_D 1.373 0.99
14_A 71_V 1.366 0.99
14_A 84_V 1.358 0.99
19_V 62_K 1.346 0.99
3_Y 97_A 1.343 0.99
133_V 147_E 1.343 0.99
28_K 31_E 1.338 0.99
131_F 149_Y 1.291 0.98
112_Q 116_S 1.27 0.98
7_Q 91_G 1.27 0.98
109_P 113_F 1.253 0.98
123_Y 152_V 1.246 0.98
108_K 148_M 1.241 0.98
15_G 66_D 1.227 0.98
136_N 144_W 1.226 0.98
90_T 128_K 1.226 0.98
51_Y 63_L 1.224 0.98
17_H 66_D 1.219 0.98
19_V 64_R 1.205 0.97
8_E 131_F 1.202 0.97
12_T 74_Y 1.202 0.97
66_D 87_T 1.2 0.97
92_G 128_K 1.19 0.97
3_Y 117_L 1.175 0.97
3_Y 112_Q 1.169 0.97
113_F 150_V 1.166 0.97
139_A 146_I 1.159 0.96
99_A 110_W 1.159 0.96
15_G 87_T 1.158 0.96
27_K 132_E 1.154 0.96
118_L 125_M 1.144 0.96
51_Y 132_E 1.111 0.95
98_V 145_D 1.086 0.94
10_K 90_T 1.08 0.94
8_E 11_R 1.072 0.94
25_T 28_K 1.059 0.93
94_Y 128_K 1.044 0.93
78_P 83_G 1.044 0.93
33_L 48_V 1.042 0.93
90_T 93_Q 1.032 0.92
20_G 54_N 1.029 0.92
49_A 134_Y 1.027 0.92
138_G 141_D 1.019 0.91
105_D 108_K 1.013 0.91
109_P 148_M 1.008 0.91
114_F 125_M 1.005 0.91
30_F 134_Y 1.001 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1jyhA111000.165Contact Map0.695
3lurA30.92991000.223Contact Map0.749
3gk6A10.89171000.239Contact Map0.68
3b49A10.968299.90.311Contact Map0.719
1d5yA40.961899.90.318Contact Map0.695
3e0hA10.929999.90.338Contact Map0.664
1r8eA10.942799.90.343Contact Map0.62
2govA10.942787.20.865Contact Map0.524
4b0yA10.980987.20.865Contact Map0.616
3r8jA20.980985.50.869Contact Map0.664
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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