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OPENSEQ.org
YJCE - Uncharacterized Na(+)/H(+) exchanger YjcE
UniProt: P32703 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11940
Length: 549 (539)
Sequences: 891
Seq/Len: 1.65
YJCE
Paralog alert: 0.24 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
374_T 401_A 3.772 1.00
320_I 403_G 2.938 1.00
324_Y 407_F 2.465 1.00
163_L 380_S 2.364 1.00
226_F 278_L 2.247 0.99
128_A 148_L 2.175 0.99
366_F 415_M 2.135 0.99
78_F 85_I 2.062 0.99
191_G 241_V 2.046 0.99
126_T 372_A 1.994 0.98
167_V 381_I 1.987 0.98
251_G 286_V 1.978 0.98
515_E 518_H 1.945 0.98
332_F 365_S 1.941 0.98
103_L 326_A 1.896 0.98
160_L 377_G 1.889 0.97
79_L 82_G 1.814 0.97
36_A 40_L 1.803 0.96
290_L 372_A 1.767 0.96
176_F 181_A 1.74 0.95
182_T 186_M 1.735 0.95
126_T 290_L 1.721 0.95
126_T 131_L 1.72 0.95
366_F 413_V 1.691 0.94
102_F 113_L 1.665 0.94
97_V 162_S 1.647 0.93
316_L 400_L 1.643 0.93
63_P 225_L 1.629 0.93
17_S 37_I 1.608 0.92
407_F 411_V 1.599 0.92
321_I 407_F 1.597 0.92
173_T 176_F 1.589 0.91
131_L 369_V 1.588 0.91
442_T 516_L 1.582 0.91
374_T 508_A 1.577 0.91
46_F 408_S 1.56 0.90
378_V 397_L 1.556 0.90
101_G 113_L 1.553 0.90
232_S 250_A 1.542 0.90
73_T 78_F 1.535 0.89
131_L 372_A 1.522 0.89
519_L 525_I 1.512 0.89
366_F 369_V 1.496 0.88
388_G 391_F 1.494 0.88
91_A 95_V 1.489 0.87
105_Y 113_L 1.486 0.87
7_I 239_I 1.445 0.85
373_I 541_E 1.443 0.85
190_I 193_I 1.44 0.85
95_V 330_V 1.439 0.85
518_H 522_T 1.437 0.85
513_R 541_E 1.434 0.85
286_V 372_A 1.432 0.85
187_K 241_V 1.431 0.85
157_A 374_T 1.424 0.84
64_P 157_A 1.405 0.83
165_F 405_I 1.4 0.83
449_A 452_K 1.399 0.83
154_M 245_L 1.396 0.82
89_A 222_I 1.394 0.82
384_L 388_G 1.392 0.82
124_S 370_R 1.391 0.82
30_L 67_F 1.369 0.81
419_L 423_I 1.366 0.81
118_A 167_V 1.363 0.80
516_L 530_L 1.361 0.80
186_M 198_V 1.359 0.80
236_A 241_V 1.349 0.79
520_R 530_L 1.349 0.79
118_A 381_I 1.343 0.79
61_F 71_W 1.343 0.79
152_A 519_L 1.339 0.79
220_T 381_I 1.329 0.78
91_A 334_W 1.323 0.78
131_L 163_L 1.321 0.77
61_F 370_R 1.311 0.77
31_P 293_Q 1.301 0.76
92_L 229_P 1.3 0.76
147_I 150_G 1.295 0.75
359_R 363_I 1.291 0.75
123_L 134_I 1.29 0.75
171_M 392_P 1.287 0.75
99_G 330_V 1.286 0.75
418_I 422_H 1.282 0.74
442_T 512_E 1.274 0.74
100_I 327_L 1.273 0.74
128_A 131_L 1.27 0.73
237_E 240_G 1.269 0.73
28_I 134_I 1.267 0.73
119_L 401_A 1.26 0.73
194_L 329_L 1.257 0.72
92_L 334_W 1.249 0.72
36_A 479_G 1.235 0.70
89_A 409_L 1.232 0.70
65_L 233_Y 1.232 0.70
30_L 283_N 1.229 0.70
100_I 323_I 1.227 0.70
438_A 525_I 1.227 0.70
125_P 148_L 1.226 0.70
161_V 379_L 1.223 0.69
377_G 544_L 1.221 0.69
527_N 531_Q 1.221 0.69
123_L 133_G 1.219 0.69
125_P 166_A 1.209 0.68
229_P 284_G 1.206 0.68
265_L 445_V 1.205 0.68
125_P 128_A 1.205 0.68
21_T 317_F 1.203 0.67
88_L 335_L 1.198 0.67
165_F 173_T 1.196 0.67
140_I 334_W 1.195 0.67
41_L 297_I 1.194 0.67
525_I 529_T 1.192 0.66
109_P 170_A 1.191 0.66
21_T 537_L 1.189 0.66
449_A 507_A 1.185 0.66
394_R 398_V 1.184 0.66
446_A 511_S 1.18 0.65
123_L 126_T 1.179 0.65
181_A 399_F 1.174 0.65
4_F 56_L 1.172 0.65
152_A 192_G 1.169 0.64
34_Q 57_F 1.166 0.64
96_T 100_I 1.166 0.64
85_I 405_I 1.164 0.64
229_P 250_A 1.163 0.64
98_V 329_L 1.163 0.64
68_A 279_E 1.162 0.64
226_F 233_Y 1.158 0.63
245_L 249_A 1.157 0.63
385_L 388_G 1.156 0.63
509_L 537_L 1.153 0.63
200_S 378_V 1.153 0.63
321_I 325_A 1.15 0.62
74_P 124_S 1.146 0.62
122_V 377_G 1.134 0.61
441_A 515_E 1.133 0.61
248_V 373_I 1.132 0.61
120_A 408_S 1.131 0.60
105_Y 112_P 1.131 0.60
97_V 438_A 1.13 0.60
66_L 93_V 1.128 0.60
233_Y 243_G 1.127 0.60
176_F 251_G 1.125 0.60
8_L 181_A 1.123 0.60
64_P 233_Y 1.121 0.59
7_I 61_F 1.12 0.59
116_A 230_F 1.119 0.59
165_F 188_V 1.116 0.59
32_L 410_F 1.115 0.59
59_V 286_V 1.114 0.59
104_I 116_A 1.114 0.59
317_F 411_V 1.114 0.59
92_L 284_G 1.113 0.59
128_A 378_V 1.111 0.58
144_I 364_A 1.11 0.58
163_L 381_I 1.108 0.58
149_Q 225_L 1.108 0.58
374_T 399_F 1.105 0.58
59_V 405_I 1.105 0.58
439_R 533_L 1.099 0.57
60_L 406_L 1.098 0.57
31_P 369_V 1.092 0.56
163_L 362_L 1.091 0.56
67_F 229_P 1.09 0.56
63_P 232_S 1.089 0.56
325_A 419_L 1.088 0.56
370_R 538_D 1.087 0.56
31_P 132_S 1.087 0.56
513_R 538_D 1.086 0.56
235_I 240_G 1.085 0.56
11_T 178_V 1.085 0.56
541_E 545_I 1.085 0.56
9_I 202_L 1.084 0.56
78_F 154_M 1.083 0.55
372_A 402_A 1.082 0.55
357_T 360_E 1.081 0.55
103_L 526_S 1.081 0.55
34_Q 412_G 1.081 0.55
244_I 247_A 1.08 0.55
114_I 171_M 1.08 0.55
526_S 529_T 1.079 0.55
144_I 222_I 1.079 0.55
170_A 176_F 1.077 0.55
118_A 171_M 1.073 0.54
14_V 92_L 1.071 0.54
66_L 247_A 1.07 0.54
363_I 486_D 1.069 0.54
112_P 115_P 1.069 0.54
229_P 417_P 1.068 0.54
324_Y 408_S 1.068 0.54
148_L 375_L 1.067 0.54
61_F 372_A 1.067 0.54
229_P 232_S 1.067 0.54
118_A 166_A 1.064 0.53
167_V 398_V 1.063 0.53
29_P 414_V 1.063 0.53
73_T 125_P 1.059 0.53
69_D 120_A 1.059 0.53
31_P 128_A 1.057 0.53
111_I 115_P 1.055 0.53
245_L 274_T 1.055 0.53
96_T 160_L 1.054 0.52
58_L 124_S 1.054 0.52
104_I 323_I 1.052 0.52
237_E 248_V 1.048 0.52
510_R 541_E 1.046 0.52
24_M 421_Q 1.043 0.51
159_G 405_I 1.043 0.51
128_A 530_L 1.039 0.51
137_E 167_V 1.039 0.51
125_P 230_F 1.037 0.51
223_V 366_F 1.037 0.51
240_G 476_R 1.036 0.51
122_V 204_G 1.036 0.51
113_L 286_V 1.036 0.51
34_Q 366_F 1.036 0.51
280_F 443_A 1.035 0.50
103_L 106_W 1.035 0.50
190_I 333_G 1.035 0.50
22_R 31_P 1.034 0.50
122_V 381_I 1.033 0.50
58_L 120_A 1.033 0.50
57_F 63_P 1.032 0.50
115_P 397_L 1.031 0.50
121_A 166_A 1.029 0.50
40_L 110_G 1.028 0.50
91_A 117_F 1.028 0.50
382_P 391_F 1.028 0.50
161_V 398_V 1.028 0.50
128_A 152_A 1.026 0.49
408_S 427_D 1.025 0.49
72_K 149_Q 1.024 0.49
130_A 133_G 1.024 0.49
59_V 234_L 1.023 0.49
13_V 288_L 1.023 0.49
160_L 188_V 1.022 0.49
230_F 417_P 1.02 0.49
202_L 249_A 1.019 0.49
199_V 235_I 1.019 0.49
128_A 282_F 1.017 0.49
110_G 481_L 1.017 0.49
18_G 22_R 1.014 0.48
100_I 104_I 1.014 0.48
200_S 204_G 1.014 0.48
284_G 399_F 1.014 0.48
320_I 399_F 1.014 0.48
50_V 376_A 1.013 0.48
8_L 117_F 1.013 0.48
67_F 220_T 1.012 0.48
225_L 275_W 1.011 0.48
369_V 372_A 1.009 0.48
382_P 394_R 1.009 0.48
78_F 335_L 1.009 0.48
159_G 413_V 1.008 0.48
370_R 408_S 1.008 0.48
131_L 134_I 1.007 0.47
65_L 251_G 1.006 0.47
30_L 140_I 1.003 0.47
66_L 237_E 1.003 0.47
31_P 370_R 1.002 0.47
62_I 244_I 1 0.47
4_F 59_V 1 0.47
75_T 78_F 1 0.47
71_W 247_A 1 0.47
236_A 335_L 1 0.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4bwzA10.70671000.701Contact Map0.301
2l0eA10.060198.70.926Contact Map0.471
2htgA10.05198.50.929Contact Map0
2k3cA10.060198.50.93Contact Map0.198
2m7xA10.0546980.939Contact Map0.219
1zcdA20.661297.60.944Contact Map0.153
2kbvA10.05197.10.948Contact Map0.687
1y4eA10.049280.70.969Contact Map0
1nvpD10.091136.20.977Contact Map0.642
3zuxA10.582933.60.977Contact Map0.17
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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