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OPENSEQ.org
NUDC - NADH pyrophosphatase
UniProt: P32664 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11702
Length: 257 (247)
Sequences: 759
Seq/Len: 3.07
NUDC
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
154_H 222_E 5.707 1.00
242_R 246_E 3.321 1.00
176_M 182_K 3.141 1.00
137_R 140_S 2.996 1.00
185_N 207_E 2.804 1.00
172_A 186_L 2.636 1.00
101_C 119_C 2.605 1.00
167_L 202_T 2.554 1.00
101_C 116_C 2.457 1.00
98_C 101_C 2.37 1.00
134_A 141_I 2.369 1.00
98_C 116_C 2.333 1.00
130_C 239_T 2.243 1.00
103_H 117_S 2.214 1.00
182_K 209_D 2.2 1.00
141_I 245_I 2.165 1.00
135_I 206_A 2.138 1.00
203_A 240_V 2.08 1.00
116_C 119_C 2.041 1.00
179_S 220_L 2.028 1.00
169_Q 172_A 2.025 1.00
184_K 209_D 1.96 1.00
98_C 119_C 1.946 1.00
144_A 157_L 1.94 1.00
105_M 114_M 1.928 0.99
139_D 229_D 1.915 0.99
234_L 242_R 1.877 0.99
145_Q 221_L 1.854 0.99
184_K 207_E 1.812 0.99
132_I 240_V 1.706 0.98
147_T 221_L 1.698 0.98
84_R 112_W 1.673 0.98
92_Y 114_M 1.661 0.98
140_S 227_R 1.658 0.98
142_L 181_I 1.628 0.98
161_V 167_L 1.621 0.98
189_V 247_D 1.619 0.98
146_H 155_T 1.617 0.98
171_V 183_V 1.596 0.97
146_H 149_H 1.58 0.97
172_A 184_K 1.544 0.97
213_I 223_A 1.538 0.97
167_L 200_L 1.536 0.97
167_L 204_F 1.521 0.96
94_S 100_Y 1.453 0.95
75_D 78_L 1.416 0.94
217_P 220_L 1.413 0.94
136_R 207_E 1.403 0.93
187_R 207_E 1.384 0.93
151_N 221_L 1.346 0.91
106_Y 117_S 1.341 0.91
208_Y 211_G 1.325 0.91
149_H 155_T 1.315 0.90
132_I 203_A 1.312 0.90
130_C 204_F 1.311 0.90
133_V 157_L 1.299 0.89
164_G 191_S 1.29 0.89
153_V 226_Y 1.288 0.89
135_I 175_V 1.279 0.88
141_I 156_V 1.277 0.88
161_V 188_Y 1.276 0.88
95_H 123_Y 1.274 0.88
32_E 35_N 1.265 0.88
130_C 199_S 1.258 0.87
56_L 89_A 1.232 0.86
147_T 215_I 1.231 0.86
133_V 175_V 1.225 0.85
33_A 37_D 1.22 0.85
144_A 179_S 1.216 0.85
160_F 197_P 1.212 0.84
168_E 191_S 1.208 0.84
132_I 241_A 1.206 0.84
145_Q 150_R 1.199 0.84
95_H 199_S 1.195 0.83
227_R 230_D 1.192 0.83
157_L 179_S 1.191 0.83
144_A 220_L 1.188 0.83
95_H 105_M 1.181 0.82
164_G 183_V 1.173 0.82
11_G 53_P 1.169 0.81
126_Q 162_E 1.167 0.81
235_P 241_A 1.16 0.81
167_L 191_S 1.151 0.80
115_L 122_R 1.148 0.80
215_I 218_K 1.135 0.79
143_L 231_L 1.132 0.79
130_C 156_V 1.126 0.78
154_H 226_Y 1.117 0.77
87_Q 198_Q 1.08 0.74
136_R 202_T 1.072 0.73
156_V 244_L 1.064 0.72
166_T 193_P 1.062 0.72
228_Y 248_T 1.057 0.71
99_G 161_V 1.056 0.71
166_T 207_E 1.053 0.71
130_C 236_P 1.052 0.71
87_Q 114_M 1.046 0.70
143_L 226_Y 1.046 0.70
97_Y 104_E 1.041 0.70
28_L 31_G 1.037 0.69
56_L 59_Q 1.028 0.68
14_V 54_V 1.02 0.68
183_V 186_L 1.015 0.67
112_W 241_A 1.001 0.65
82_A 156_V 1 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vk6A111000.365Contact Map0.682
3cngA40.63041000.711Contact Map0.64
2qjtB20.972899.90.73Contact Map0.42
2a6tA20.797799.90.761Contact Map0.49
3q1pA20.708299.90.767Contact Map0.495
4hfqA20.712199.90.773Contact Map0.517
2qjoA30.953399.80.793Contact Map0.371
2b0vA10.533199.80.793Contact Map0.468
3fjyA20.548699.80.796Contact Map0.393
3shdA120.521499.70.806Contact Map0.531
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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