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OPENSEQ.org
FRVR - Putative frv operon regulatory protein
UniProt: P32152 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11861
Length: 582 (579)
Sequences: 995
Seq/Len: 1.72
FRVR
Paralog alert: 0.44 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
5_R 37_D 4.426 1.00
103_L 108_V 3.641 1.00
123_C 137_E 3.375 1.00
29_V 34_I 3.344 1.00
38_I 42_N 3.282 1.00
269_D 343_R 2.967 1.00
103_L 107_W 2.641 1.00
139_E 143_V 2.621 1.00
571_G 574_A 2.605 1.00
302_K 329_D 2.59 1.00
103_L 111_R 2.537 1.00
521_L 524_P 2.417 1.00
33_T 37_D 2.309 1.00
533_N 567_A 2.249 0.99
23_L 34_I 2.213 0.99
302_K 309_F 2.211 0.99
286_A 290_I 2.147 0.99
116_K 127_S 2.121 0.99
489_R 495_N 2.111 0.99
362_T 365_Q 2.105 0.99
139_E 199_R 2.104 0.99
490_E 495_N 2.102 0.99
461_W 527_V 2.025 0.99
350_P 376_R 2.018 0.99
286_A 289_W 2.013 0.99
466_R 483_A 1.997 0.99
31_G 35_L 1.977 0.98
312_S 334_G 1.932 0.98
5_R 33_T 1.923 0.98
460_S 463_H 1.901 0.98
123_C 135_I 1.853 0.97
495_N 527_V 1.834 0.97
286_A 295_Q 1.833 0.97
272_L 276_I 1.807 0.97
269_D 340_A 1.802 0.97
354_L 357_Q 1.778 0.96
468_I 519_I 1.778 0.96
502_A 532_I 1.763 0.96
570_T 574_A 1.754 0.96
30_S 33_T 1.753 0.96
462_Q 491_G 1.747 0.96
469_C 483_A 1.728 0.95
126_A 136_D 1.725 0.95
12_L 27_T 1.68 0.94
364_N 401_N 1.666 0.94
81_R 111_R 1.653 0.94
267_I 337_F 1.637 0.93
118_R 145_L 1.637 0.93
365_Q 369_E 1.625 0.93
403_H 415_T 1.601 0.92
12_L 23_L 1.585 0.92
457_R 522_A 1.584 0.92
29_V 33_T 1.581 0.92
486_I 495_N 1.564 0.91
468_I 537_I 1.55 0.91
5_R 9_I 1.546 0.91
260_P 266_N 1.543 0.90
102_N 527_V 1.538 0.90
3_N 6_Q 1.532 0.90
276_I 333_I 1.531 0.90
193_L 197_A 1.525 0.90
450_S 575_F 1.524 0.90
137_E 142_R 1.513 0.89
93_P 132_G 1.503 0.89
123_C 142_R 1.503 0.89
94_R 105_E 1.495 0.88
24_A 31_G 1.488 0.88
495_N 504_P 1.479 0.88
469_C 537_I 1.47 0.87
316_I 333_I 1.468 0.87
464_I 519_I 1.466 0.87
12_L 18_R 1.458 0.87
399_I 416_V 1.457 0.87
524_P 533_N 1.457 0.87
336_Y 339_C 1.456 0.87
272_L 343_R 1.453 0.87
472_L 478_I 1.442 0.86
263_A 311_M 1.433 0.85
486_I 537_I 1.424 0.85
138_T 141_K 1.419 0.85
122_T 141_K 1.416 0.85
190_S 194_A 1.415 0.85
258_R 261_G 1.409 0.84
290_I 296_S 1.405 0.84
137_E 143_V 1.4 0.84
399_I 412_N 1.377 0.82
473_V 480_A 1.373 0.82
445_F 450_S 1.372 0.82
469_C 486_I 1.371 0.82
308_A 312_S 1.37 0.82
461_W 490_E 1.368 0.82
95_A 105_E 1.367 0.82
279_H 336_Y 1.363 0.81
478_I 539_C 1.362 0.81
490_E 527_V 1.362 0.81
496_L 527_V 1.362 0.81
42_N 53_A 1.362 0.81
107_W 111_R 1.352 0.81
272_L 340_A 1.348 0.80
382_S 385_E 1.347 0.80
229_A 232_T 1.344 0.80
105_E 132_G 1.338 0.80
63_I 69_F 1.337 0.80
572_Y 575_F 1.336 0.80
353_L 368_I 1.332 0.79
252_V 256_L 1.332 0.79
340_A 343_R 1.332 0.79
290_I 295_Q 1.33 0.79
477_H 513_R 1.322 0.79
368_I 372_V 1.318 0.78
115_L 119_Y 1.316 0.78
38_I 59_Y 1.315 0.78
458_G 467_Q 1.314 0.78
128_R 131_L 1.312 0.78
473_V 478_I 1.304 0.77
184_Q 187_Y 1.304 0.77
450_S 572_Y 1.295 0.77
367_A 371_D 1.294 0.76
351_I 375_C 1.293 0.76
13_L 357_Q 1.288 0.76
77_D 81_R 1.282 0.76
465_T 483_A 1.282 0.76
399_I 414_I 1.281 0.75
91_F 134_F 1.274 0.75
184_Q 190_S 1.267 0.74
424_G 427_Q 1.266 0.74
470_A 474_A 1.264 0.74
364_N 367_A 1.258 0.74
279_H 505_H 1.252 0.73
500_R 533_N 1.251 0.73
572_Y 576_M 1.25 0.73
267_I 331_D 1.249 0.73
287_P 290_I 1.247 0.73
49_A 63_I 1.246 0.73
339_C 343_R 1.246 0.73
482_E 486_I 1.245 0.72
263_A 267_I 1.245 0.72
367_A 419_I 1.243 0.72
490_E 496_L 1.241 0.72
320_R 326_P 1.238 0.72
98_A 103_L 1.238 0.72
259_V 337_F 1.237 0.72
196_Y 199_R 1.233 0.71
482_E 539_C 1.23 0.71
29_V 37_D 1.227 0.71
286_A 293_H 1.223 0.71
190_S 193_L 1.223 0.71
486_I 490_E 1.22 0.70
300_N 304_A 1.219 0.70
298_M 329_D 1.218 0.70
9_I 23_L 1.217 0.70
569_L 574_A 1.212 0.70
486_I 496_L 1.209 0.69
489_R 527_V 1.208 0.69
32_R 36_R 1.203 0.69
414_I 424_G 1.201 0.69
230_V 331_D 1.2 0.68
32_R 338_A 1.196 0.68
490_E 504_P 1.188 0.67
253_Q 273_V 1.188 0.67
461_W 487_I 1.184 0.67
129_P 132_G 1.184 0.67
563_A 567_A 1.182 0.67
506_C 519_I 1.177 0.66
478_I 482_E 1.17 0.66
521_L 525_V 1.158 0.64
328_F 331_D 1.157 0.64
287_P 295_Q 1.156 0.64
275_N 362_T 1.156 0.64
254_G 322_Q 1.155 0.64
33_T 36_R 1.153 0.64
357_Q 360_I 1.152 0.64
252_V 280_L 1.152 0.64
511_E 515_R 1.151 0.64
495_N 514_F 1.15 0.64
191_L 225_L 1.149 0.64
283_C 287_P 1.147 0.63
486_I 516_G 1.143 0.63
296_S 332_L 1.142 0.63
465_T 469_C 1.14 0.63
38_I 51_I 1.138 0.62
327_L 331_D 1.138 0.62
38_I 53_A 1.137 0.62
521_L 533_N 1.129 0.62
127_S 133_H 1.121 0.61
112_L 125_L 1.12 0.61
339_C 342_E 1.119 0.60
105_E 536_L 1.118 0.60
82_L 363_I 1.116 0.60
482_E 504_P 1.11 0.60
551_F 555_A 1.109 0.59
356_D 359_A 1.109 0.59
84_A 100_A 1.108 0.59
516_G 536_L 1.106 0.59
35_L 269_D 1.105 0.59
273_V 368_I 1.103 0.59
19_T 335_L 1.102 0.59
105_E 109_A 1.102 0.59
352_I 381_R 1.101 0.59
428_I 432_L 1.1 0.59
98_A 108_V 1.095 0.58
272_L 275_N 1.095 0.58
418_N 421_T 1.095 0.58
482_E 495_N 1.094 0.58
129_P 308_A 1.09 0.57
189_S 444_F 1.089 0.57
357_Q 402_S 1.088 0.57
93_P 109_A 1.086 0.57
308_A 334_G 1.084 0.57
336_Y 359_A 1.083 0.57
32_R 35_L 1.081 0.57
255_L 318_L 1.077 0.56
275_N 343_R 1.075 0.56
58_G 527_V 1.073 0.56
24_A 29_V 1.071 0.55
461_W 495_N 1.07 0.55
2_L 6_Q 1.069 0.55
59_Y 572_Y 1.068 0.55
489_R 504_P 1.068 0.55
286_A 291_A 1.068 0.55
302_K 338_A 1.066 0.55
53_A 59_Y 1.066 0.55
469_C 473_V 1.066 0.55
93_P 129_P 1.064 0.55
36_R 482_E 1.064 0.55
286_A 296_S 1.063 0.55
416_V 420_I 1.062 0.55
17_P 58_G 1.062 0.55
115_L 125_L 1.06 0.54
184_Q 188_L 1.059 0.54
6_Q 37_D 1.058 0.54
517_F 537_I 1.052 0.53
108_V 115_L 1.052 0.53
296_S 330_S 1.051 0.53
10_V 19_T 1.05 0.53
276_I 336_Y 1.05 0.53
20_P 59_Y 1.049 0.53
495_N 540_A 1.046 0.53
32_R 37_D 1.045 0.53
296_S 402_S 1.042 0.52
417_K 424_G 1.041 0.52
269_D 342_E 1.041 0.52
95_A 131_L 1.04 0.52
489_R 537_I 1.039 0.52
280_L 298_M 1.039 0.52
33_T 58_G 1.038 0.52
464_I 535_V 1.038 0.52
118_R 501_L 1.038 0.52
282_R 336_Y 1.037 0.52
520_T 534_H 1.036 0.52
540_A 551_F 1.031 0.51
507_W 540_A 1.027 0.51
3_N 37_D 1.024 0.50
256_L 312_S 1.023 0.50
447_A 573_E 1.022 0.50
283_C 575_F 1.021 0.50
302_K 493_G 1.02 0.50
6_Q 40_Y 1.02 0.50
26_Q 124_C 1.019 0.50
13_L 24_A 1.016 0.50
135_I 399_I 1.012 0.49
336_Y 343_R 1.011 0.49
473_V 483_A 1.01 0.49
519_I 535_V 1.009 0.49
495_N 547_E 1.008 0.49
351_I 377_V 1.006 0.49
221_S 226_G 1.004 0.48
189_S 193_L 1.004 0.48
495_N 516_G 1.003 0.48
357_Q 361_A 1.002 0.48
331_D 354_L 1.002 0.48
357_Q 404_Y 1 0.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3sqnA20.7321000.504Contact Map0.548
1a6jA20.25699.90.783Contact Map0.6
3oxpA20.245799.90.785Contact Map0.65
3bjvA10.24499.90.787Contact Map0.683
2oq3A10.247499.90.788Contact Map0.601
1a3aA40.240599.90.788Contact Map0.634
2oqtA40.24499.90.789Contact Map0.734
2a0jA10.245799.90.793Contact Map0.563
3urrA20.249199.90.794Contact Map0.596
3lf6A20.254399.90.795Contact Map0.641
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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