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OPENSEQ.org
LPLA - Lipoate-protein ligase A
UniProt: P32099 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11796
Length: 338 (332)
Sequences: 687
Seq/Len: 2.07
LPLA
Paralog alert: 0.16 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
41_A 67_R 2.473 1.00
80_H 86_C 2.401 1.00
156_N 189_T 2.348 1.00
38_W 88_T 2.342 1.00
103_S 107_N 2.342 1.00
186_T 191_L 2.255 1.00
272_E 277_T 2.2 1.00
110_N 115_S 2.18 1.00
259_R 264_G 2.142 0.99
136_S 152_T 2.095 0.99
61_M 68_L 2.008 0.99
44_V 61_M 1.838 0.98
170_K 174_A 1.82 0.98
17_N 40_N 1.756 0.97
85_T 197_H 1.732 0.97
88_T 149_H 1.685 0.96
46_I 52_P 1.64 0.95
124_L 135_V 1.628 0.95
172_K 284_D 1.602 0.95
119_S 125_V 1.594 0.94
135_V 186_T 1.586 0.94
122_N 172_K 1.581 0.94
87_F 151_G 1.576 0.94
242_W 247_G 1.559 0.93
125_V 128_T 1.548 0.93
64_D 165_Y 1.547 0.93
231_N 235_T 1.544 0.93
186_T 190_E 1.539 0.93
78_V 152_T 1.535 0.93
302_L 307_M 1.535 0.93
305_A 309_Q 1.533 0.93
111_A 210_A 1.532 0.93
21_E 150_H 1.526 0.92
304_R 307_M 1.521 0.92
84_N 152_T 1.519 0.92
40_N 80_H 1.497 0.91
45_V 78_V 1.49 0.91
22_E 238_R 1.485 0.91
120_G 172_K 1.479 0.91
173_L 177_G 1.476 0.91
45_V 84_N 1.476 0.91
305_A 331_A 1.476 0.91
294_L 315_L 1.467 0.90
111_A 207_A 1.462 0.90
172_K 184_R 1.46 0.90
196_T 199_Q 1.451 0.90
14_P 18_L 1.445 0.89
301_C 311_E 1.445 0.89
17_N 21_E 1.442 0.89
79_F 175_A 1.44 0.89
58_T 62_E 1.436 0.89
80_H 157_A 1.422 0.88
60_R 64_D 1.42 0.88
60_R 165_Y 1.416 0.88
184_R 284_D 1.41 0.88
16_F 226_T 1.402 0.87
154_L 157_A 1.389 0.87
301_C 307_M 1.379 0.86
73_S 141_R 1.377 0.86
45_V 80_H 1.375 0.86
155_L 200_V 1.36 0.85
308_L 334_A 1.348 0.85
45_V 152_T 1.347 0.85
18_L 21_E 1.34 0.84
43_T 80_H 1.339 0.84
80_H 84_N 1.333 0.84
24_I 33_R 1.322 0.83
22_E 239_Q 1.322 0.83
297_R 315_L 1.315 0.83
38_W 149_H 1.31 0.82
253_S 270_D 1.295 0.81
120_G 184_R 1.293 0.81
242_W 249_A 1.29 0.81
107_N 210_A 1.283 0.80
78_V 84_N 1.263 0.79
107_N 207_A 1.256 0.78
122_N 184_R 1.255 0.78
307_M 310_Q 1.254 0.78
24_I 28_M 1.247 0.78
159_L 163_A 1.239 0.77
133_R 186_T 1.239 0.77
108_A 207_A 1.238 0.77
126_V 188_L 1.236 0.77
252_F 271_V 1.233 0.77
120_G 284_D 1.231 0.76
35_L 252_F 1.226 0.76
54_K 179_T 1.222 0.76
306_D 310_Q 1.218 0.75
122_N 263_G 1.214 0.75
22_E 26_R 1.213 0.75
14_P 86_C 1.211 0.75
37_L 88_T 1.211 0.75
224_N 227_P 1.206 0.74
117_E 128_T 1.201 0.74
252_F 303_Y 1.196 0.73
52_P 68_L 1.193 0.73
139_A 150_H 1.184 0.72
27_Q 228_D 1.183 0.72
14_P 80_H 1.179 0.72
72_S 238_R 1.177 0.72
54_K 175_A 1.175 0.72
309_Q 327_R 1.164 0.71
38_W 45_V 1.163 0.70
101_S 104_I 1.158 0.70
116_A 126_V 1.157 0.70
78_V 86_C 1.147 0.69
280_Q 295_A 1.142 0.68
261_T 328_E 1.138 0.68
12_Y 82_L 1.138 0.68
18_L 86_C 1.137 0.68
289_A 319_F 1.135 0.68
17_N 80_H 1.133 0.68
69_A 245_N 1.129 0.67
49_A 178_I 1.128 0.67
222_S 225_K 1.126 0.67
133_R 190_E 1.118 0.66
310_Q 313_E 1.117 0.66
39_R 197_H 1.117 0.66
66_V 165_Y 1.116 0.66
314_A 329_L 1.115 0.66
25_F 69_A 1.111 0.65
112_L 203_A 1.107 0.65
122_N 284_D 1.106 0.65
18_L 239_Q 1.096 0.64
172_K 263_G 1.094 0.64
120_G 263_G 1.089 0.63
14_P 40_N 1.086 0.63
277_T 300_G 1.085 0.63
115_S 127_K 1.083 0.62
121_R 181_V 1.082 0.62
309_Q 313_E 1.07 0.61
38_W 96_Y 1.07 0.61
140_Y 149_H 1.064 0.60
278_R 299_Q 1.064 0.60
135_V 170_K 1.062 0.60
49_A 141_R 1.062 0.60
83_G 187_N 1.059 0.60
297_R 311_E 1.059 0.60
65_N 108_A 1.057 0.60
220_I 248_Q 1.057 0.60
40_N 69_A 1.055 0.59
50_Q 55_E 1.05 0.59
176_K 263_G 1.049 0.59
248_Q 278_R 1.044 0.58
18_L 45_V 1.04 0.58
72_S 138_S 1.039 0.58
133_R 191_L 1.034 0.57
232_F 238_R 1.034 0.57
88_T 148_F 1.031 0.57
260_F 263_G 1.031 0.57
271_V 282_F 1.028 0.56
180_S 187_N 1.027 0.56
73_S 150_H 1.026 0.56
158_D 161_R 1.025 0.56
46_I 78_V 1.024 0.56
80_H 150_H 1.021 0.56
296_G 301_C 1.016 0.55
309_Q 326_L 1.015 0.55
99_T 103_S 1.015 0.55
306_D 313_E 1.013 0.55
17_N 150_H 1.012 0.55
228_D 231_N 1.01 0.54
172_K 176_K 1.007 0.54
60_R 66_V 1.006 0.54
85_T 200_V 1 0.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3a7rA10.9971000.203Contact Map0.495
2e5aA10.97631000.253Contact Map0.536
1vqzA10.97041000.271Contact Map0.569
2c8mA40.72781000.431Contact Map0.576
2p0lA10.73371000.535Contact Map0.379
2p5iA10.73081000.554Contact Map0.469
2qhsA10.62131000.595Contact Map0.481
1w66A10.63021000.62Contact Map0.359
3r07C10.260499.40.862Contact Map0.569
2dxuA20.636196.40.934Contact Map0.557
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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