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OPENSEQ.org
YIDK - Uncharacterized symporter YidK
UniProt: P31448 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11706
Length: 571 (483)
Sequences: 3963
Seq/Len: 8.20
YIDK
Paralog alert: 0.70 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: ACTP PANF PUTP YIDK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
442_I 474_V 6.103 1.00
442_I 470_I 4.488 1.00
370_E 373_Q 4.004 1.00
476_L 480_F 3.872 1.00
431_I 475_M 3.755 1.00
366_N 373_Q 3.582 1.00
274_S 277_E 3.442 1.00
435_A 479_G 3.337 1.00
478_I 482_K 3.288 1.00
446_S 470_I 3.282 1.00
438_V 478_I 3.217 1.00
474_V 478_I 3.068 1.00
432_P 482_K 3.025 1.00
361_Y 369_A 2.981 1.00
175_I 386_A 2.681 1.00
434_L 482_K 2.628 1.00
18_V 22_W 2.589 1.00
387_I 391_L 2.47 1.00
428_F 476_L 2.426 1.00
439_A 475_M 2.415 1.00
424_M 475_M 2.406 1.00
208_G 302_I 2.403 1.00
171_G 390_V 2.389 1.00
206_V 210_I 2.375 1.00
438_V 474_V 2.27 1.00
376_T 380_K 2.248 1.00
428_F 480_F 2.223 1.00
113_Y 431_I 2.212 1.00
432_P 479_G 2.211 1.00
219_Q 222_E 2.206 1.00
183_L 271_A 2.185 1.00
168_I 172_L 2.176 1.00
430_R 480_F 2.17 1.00
380_K 384_F 2.133 1.00
428_F 431_I 2.107 1.00
11_G 15_L 2.092 1.00
432_P 435_A 2.08 1.00
108_F 425_G 2.057 1.00
303_A 316_A 2.051 1.00
445_I 449_T 2.037 1.00
369_A 373_Q 1.979 1.00
434_L 438_V 1.977 1.00
33_Q 40_R 1.974 1.00
366_N 369_A 1.935 1.00
473_V 477_V 1.908 1.00
361_Y 366_N 1.886 1.00
19_I 192_I 1.88 1.00
42_L 187_A 1.878 1.00
14_L 18_V 1.87 1.00
421_I 436_A 1.867 1.00
372_Q 376_T 1.836 1.00
424_M 472_V 1.823 1.00
66_G 314_D 1.817 1.00
356_F 360_I 1.816 1.00
435_A 478_I 1.815 1.00
365_I 369_A 1.808 1.00
356_F 381_F 1.792 1.00
273_K 277_E 1.771 1.00
162_A 165_L 1.731 1.00
430_R 483_P 1.729 1.00
200_G 336_V 1.718 1.00
34_G 39_G 1.711 1.00
110_E 118_R 1.709 1.00
223_Q 226_T 1.699 1.00
3_S 7_L 1.681 1.00
99_K 275_L 1.68 1.00
361_Y 377_V 1.67 1.00
181_G 185_A 1.656 1.00
37_L 40_R 1.647 1.00
381_F 384_F 1.637 1.00
219_Q 223_Q 1.637 1.00
435_A 439_A 1.619 1.00
58_T 140_S 1.612 1.00
438_V 442_I 1.608 1.00
477_V 480_F 1.607 1.00
349_L 386_A 1.595 1.00
15_L 192_I 1.583 1.00
190_D 268_R 1.58 1.00
331_G 335_A 1.58 1.00
102_I 111_E 1.575 1.00
361_Y 365_I 1.558 1.00
432_P 478_I 1.55 1.00
358_M 362_R 1.544 1.00
479_G 482_K 1.529 1.00
174_G 345_F 1.516 1.00
428_F 479_G 1.511 1.00
6_I 10_V 1.498 1.00
276_A 279_Q 1.494 1.00
361_Y 373_Q 1.494 1.00
38_A 183_L 1.492 1.00
441_G 445_I 1.486 1.00
46_V 191_S 1.48 0.99
94_L 98_L 1.475 0.99
202_L 206_V 1.459 0.99
352_A 385_I 1.458 0.99
430_R 484_R 1.458 0.99
276_A 280_K 1.449 0.99
110_E 363_R 1.441 0.99
113_Y 424_M 1.44 0.99
469_C 473_V 1.428 0.99
428_F 435_A 1.428 0.99
70_K 313_A 1.425 0.99
174_G 342_I 1.422 0.99
16_V 192_I 1.413 0.99
277_E 280_K 1.404 0.99
357_S 378_G 1.403 0.99
431_I 435_A 1.392 0.99
434_L 481_I 1.391 0.99
369_A 377_V 1.385 0.99
27_T 34_G 1.371 0.99
435_A 438_V 1.368 0.99
7_L 11_G 1.367 0.99
437_K 441_G 1.365 0.99
369_A 374_L 1.333 0.99
431_I 479_G 1.33 0.99
218_M 222_E 1.328 0.99
54_T 347_G 1.321 0.99
112_R 428_F 1.29 0.98
104_T 354_T 1.29 0.98
425_G 436_A 1.285 0.98
171_G 386_A 1.279 0.98
434_L 478_I 1.275 0.98
35_Y 382_G 1.274 0.98
442_I 446_S 1.271 0.98
132_C 135_P 1.27 0.98
470_I 474_V 1.26 0.98
424_M 476_L 1.255 0.98
362_R 374_L 1.249 0.98
113_Y 475_M 1.247 0.98
321_V 333_F 1.239 0.98
319_T 323_N 1.238 0.98
263_Q 267_Q 1.235 0.98
442_I 478_I 1.225 0.97
15_L 19_I 1.223 0.97
47_I 272_S 1.216 0.97
439_A 471_N 1.214 0.97
5_Q 8_S 1.212 0.97
96_R 99_K 1.21 0.97
174_G 346_N 1.21 0.97
186_M 189_A 1.208 0.97
54_T 190_D 1.207 0.97
107_D 359_G 1.198 0.97
108_F 112_R 1.196 0.97
446_S 474_V 1.192 0.97
307_Y 323_N 1.192 0.97
36_F 378_G 1.188 0.97
50_S 347_G 1.186 0.97
44_A 277_E 1.173 0.96
373_Q 377_V 1.165 0.96
472_V 476_L 1.161 0.96
57_S 61_L 1.159 0.96
474_V 477_V 1.154 0.96
373_Q 376_T 1.152 0.96
164_W 394_P 1.15 0.96
430_R 485_A 1.15 0.96
120_I 437_K 1.148 0.96
428_F 432_P 1.147 0.96
164_W 168_I 1.144 0.96
112_R 425_G 1.14 0.95
213_G 216_S 1.138 0.95
133_F 137_V 1.135 0.95
190_D 347_G 1.132 0.95
133_F 136_I 1.122 0.95
143_L 146_N 1.119 0.95
18_V 21_W 1.117 0.95
478_I 481_I 1.115 0.95
7_L 10_V 1.112 0.95
68_A 75_V 1.111 0.95
22_W 26_K 1.095 0.94
417_P 471_N 1.095 0.94
61_L 262_N 1.093 0.94
11_G 195_I 1.091 0.94
421_I 471_N 1.088 0.94
190_D 346_N 1.088 0.94
189_A 346_N 1.086 0.94
203_M 207_F 1.079 0.93
5_Q 328_P 1.077 0.93
476_L 479_G 1.072 0.93
141_G 170_L 1.071 0.93
433_A 437_K 1.069 0.93
125_F 418_L 1.069 0.93
17_A 20_T 1.063 0.93
9_F 338_F 1.057 0.92
205_P 295_V 1.057 0.92
420_T 472_V 1.052 0.92
380_K 383_F 1.047 0.92
142_A 167_V 1.047 0.92
17_A 21_W 1.043 0.92
177_Y 185_A 1.042 0.92
430_R 433_A 1.04 0.92
12_F 342_I 1.038 0.92
403_L 406_W 1.035 0.91
94_L 97_Y 1.034 0.91
365_I 368_N 1.034 0.91
168_I 387_I 1.032 0.91
10_V 14_L 1.029 0.91
179_V 383_F 1.024 0.91
371_P 374_L 1.022 0.91
107_D 358_M 1.021 0.91
50_S 268_R 1.021 0.91
189_A 193_N 1.021 0.91
387_I 390_V 1.02 0.91
212_M 220_G 1.019 0.91
193_N 346_N 1.019 0.91
50_S 54_T 1.019 0.91
68_A 286_A 1.017 0.90
376_T 379_R 1.016 0.90
43_K 47_I 1.015 0.90
357_S 374_L 1.015 0.90
257_F 419_V 1.013 0.90
110_E 115_K 1.012 0.90
8_S 328_P 1.012 0.90
118_R 359_G 1.011 0.90
193_N 342_I 1.009 0.90
49_A 191_S 1.005 0.90
344_T 348_F 1.002 0.90
356_F 361_Y 1.001 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2xq2A10.97021000.276Contact Map0.642
3dh4A40.88091000.33Contact Map0.589
3l1lA10.754898.90.915Contact Map0.422
3giaA10.742698.30.93Contact Map0.407
2jlnA10.789898.10.934Contact Map0.434
4djkA20.837197.70.94Contact Map0.386
2wswA10.705896.80.948Contact Map0.373
4ainA30.754895.60.954Contact Map0.462
4c7rA30.784693.10.959Contact Map0.391
3j1zP20.3468200.978Contact Map0.246
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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