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OPENSEQ.org
POTG - Putrescine transport ATP-binding protein PotG
UniProt: P31134 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11630
Length: 377 (358)
Sequences: 8957
Seq/Len: 25.02
POTG
Paralog alert: 0.82 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
232_G 236_E 4.623 1.00
49_A 217_A 4.53 1.00
135_G 140_Q 4.209 1.00
46_E 219_R 3.955 1.00
75_Q 82_D 3.862 1.00
229_V 243_T 3.798 1.00
21_E 41_T 3.475 1.00
318_G 334_V 3.297 1.00
23_R 75_Q 3.179 1.00
127_A 131_N 3.164 1.00
122_P 125_E 3.031 1.00
24_N 37_D 2.894 1.00
321_I 335_R 2.855 1.00
134_L 143_A 2.843 1.00
36_D 227_K 2.756 1.00
142_F 145_R 2.696 1.00
109_E 144_K 2.673 1.00
109_E 113_A 2.644 1.00
24_N 39_S 2.631 1.00
129_R 167_R 2.596 1.00
194_D 198_R 2.548 1.00
109_E 131_N 2.543 1.00
133_M 165_A 2.538 1.00
221_A 228_F 2.527 1.00
79_D 169_K 2.49 1.00
48_F 221_A 2.469 1.00
233_E 236_E 2.439 1.00
78_L 83_L 2.434 1.00
109_E 130_V 2.414 1.00
64_M 76_I 2.4 1.00
109_E 127_A 2.342 1.00
319_E 362_E 2.341 1.00
35_V 64_M 2.313 1.00
317_V 362_E 2.31 1.00
81_V 169_K 2.304 1.00
20_L 170_L 2.213 1.00
65_L 204_V 2.179 1.00
33_H 36_D 2.17 1.00
221_A 231_I 2.164 1.00
92_P 169_K 2.136 1.00
224_N 229_V 2.098 1.00
21_E 77_M 2.092 1.00
43_Y 46_E 2.089 1.00
137_V 161_A 2.028 1.00
22_I 25_L 2.026 1.00
113_A 130_V 1.999 1.00
244_R 294_H 1.975 1.00
77_M 82_D 1.935 1.00
173_L 203_C 1.914 1.00
103_F 115_G 1.909 1.00
110_Q 117_K 1.908 1.00
26_T 37_D 1.904 1.00
128_S 132_E 1.898 1.00
22_I 65_L 1.885 1.00
28_S 33_H 1.877 1.00
112_I 161_A 1.875 1.00
319_E 335_R 1.863 1.00
63_R 69_E 1.858 1.00
138_H 187_R 1.847 1.00
317_V 364_R 1.831 1.00
125_E 128_S 1.825 1.00
23_R 77_M 1.816 1.00
126_I 130_V 1.814 1.00
358_T 361_D 1.81 1.00
26_T 33_H 1.798 1.00
222_I 246_S 1.795 1.00
113_A 126_I 1.78 1.00
26_T 73_A 1.763 1.00
27_K 64_M 1.751 1.00
81_V 86_V 1.703 1.00
48_F 231_I 1.693 1.00
253_V 296_A 1.69 1.00
259_V 292_P 1.67 1.00
244_R 255_V 1.654 1.00
124_A 128_S 1.652 1.00
238_Y 300_E 1.652 1.00
244_R 248_E 1.622 1.00
35_V 61_L 1.619 1.00
107_T 110_Q 1.604 1.00
27_K 69_E 1.604 1.00
22_I 40_L 1.595 1.00
121_L 125_E 1.587 1.00
64_M 71_P 1.585 1.00
248_E 255_V 1.572 1.00
121_L 126_I 1.557 1.00
112_I 134_L 1.551 1.00
83_L 86_V 1.525 1.00
255_V 294_H 1.519 1.00
132_E 167_R 1.495 1.00
56_C 223_M 1.49 1.00
115_G 166_K 1.486 1.00
27_K 72_S 1.483 1.00
48_F 219_R 1.473 1.00
87_P 90_L 1.471 1.00
257_E 292_P 1.467 1.00
133_M 164_L 1.463 1.00
131_N 143_A 1.456 1.00
77_M 80_G 1.448 1.00
236_E 240_H 1.429 1.00
38_V 61_L 1.428 1.00
107_T 146_K 1.426 1.00
129_R 132_E 1.424 1.00
125_E 129_R 1.423 1.00
132_E 135_G 1.409 1.00
196_L 201_V 1.401 0.99
43_Y 219_R 1.377 0.99
40_L 221_A 1.373 0.99
28_S 73_A 1.371 0.99
75_Q 84_S 1.355 0.99
177_M 192_V 1.35 0.99
193_V 216_M 1.349 0.99
71_P 76_I 1.345 0.99
329_L 345_Q 1.34 0.99
21_E 80_G 1.324 0.99
196_L 203_C 1.318 0.99
334_V 365_L 1.315 0.99
131_N 135_G 1.3 0.99
258_G 293_V 1.294 0.99
40_L 231_I 1.29 0.99
35_V 38_V 1.281 0.99
82_D 85_Q 1.28 0.99
71_P 84_S 1.268 0.99
235_E 239_E 1.266 0.99
22_I 61_L 1.263 0.99
323_I 332_Y 1.258 0.99
131_N 140_Q 1.249 0.99
94_N 166_K 1.246 0.98
224_N 245_Y 1.244 0.98
117_K 123_K 1.243 0.98
114_F 118_Q 1.242 0.98
47_I 216_M 1.231 0.98
177_M 205_M 1.213 0.98
301_K 371_S 1.21 0.98
123_K 127_A 1.207 0.98
167_R 198_R 1.204 0.98
47_I 196_L 1.2 0.98
50_L 221_A 1.198 0.98
26_T 36_D 1.193 0.98
320_V 332_Y 1.184 0.98
103_F 166_K 1.182 0.98
23_R 39_S 1.181 0.98
303_M 366_C 1.169 0.97
28_S 34_A 1.165 0.97
219_R 231_I 1.146 0.97
302_I 367_W 1.14 0.97
86_V 90_L 1.139 0.97
132_E 198_R 1.133 0.97
239_E 325_Y 1.13 0.97
24_N 73_A 1.129 0.97
25_L 71_P 1.129 0.97
230_Q 246_S 1.127 0.97
183_K 248_E 1.114 0.96
257_E 294_H 1.113 0.96
94_N 203_C 1.113 0.96
44_K 79_D 1.11 0.96
25_L 64_M 1.104 0.96
76_I 83_L 1.103 0.96
232_G 237_I 1.096 0.96
100_Y 179_A 1.079 0.95
297_L 302_I 1.068 0.95
110_Q 113_A 1.061 0.95
134_L 139_M 1.058 0.95
138_H 191_E 1.053 0.95
112_I 130_V 1.053 0.95
210_Q 249_F 1.051 0.94
112_I 133_M 1.047 0.94
61_L 223_M 1.043 0.94
305_C 364_R 1.03 0.94
78_L 93_I 1.015 0.93
318_G 336_L 1.01 0.93
119_D 166_K 1.008 0.93
193_V 197_E 1.004 0.93
368_E 371_S 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3d31A20.92041000.253Contact Map0.738
1v43A10.94161000.256Contact Map0.852
1oxxK10.90981000.256Contact Map0.735
2it1A20.91511000.258Contact Map0.866
3rlfA20.93371000.261Contact Map0.824
1g29120.92311000.266Contact Map0.877
2yyzA10.92571000.267Contact Map0.781
3fvqA20.91781000.268Contact Map0.751
1z47A20.9391000.295Contact Map0.838
3gd7A40.94161000.354Contact Map0.712
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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