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OPENSEQ.org
FLIH - Flagellar assembly protein FliH
UniProt: P31068 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11656
Length: 228 (227)
Sequences: 289
Seq/Len: 1.27
FLIH
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
51_A 55_G 3.102 1.00
74_E 78_Q 2.18 0.99
55_G 59_G 2.162 0.98
59_G 63_G 2.071 0.98
154_E 206_G 1.852 0.95
117_A 135_T 1.851 0.95
44_L 51_A 1.795 0.94
40_L 51_A 1.759 0.93
113_D 116_I 1.738 0.92
72_Y 76_L 1.727 0.92
47_L 51_A 1.697 0.91
40_L 47_L 1.636 0.89
129_R 151_L 1.622 0.89
7_W 11_T 1.583 0.87
62_E 66_Q 1.562 0.86
171_Q 175_D 1.542 0.85
135_T 138_V 1.529 0.84
134_Q 142_A 1.504 0.83
139_D 142_A 1.483 0.82
108_T 117_A 1.482 0.82
130_Q 133_G 1.466 0.81
64_R 68_H 1.466 0.81
70_Q 74_E 1.427 0.78
55_G 63_G 1.419 0.78
164_R 200_K 1.404 0.76
173_V 186_W 1.38 0.75
31_T 35_E 1.361 0.73
124_A 128_A 1.354 0.73
66_Q 70_Q 1.354 0.73
198_G 211_S 1.353 0.73
76_L 80_L 1.352 0.73
22_F 25_I 1.334 0.71
39_S 43_Q 1.309 0.69
136_P 139_D 1.306 0.69
150_L 206_G 1.3 0.68
198_G 203_A 1.293 0.68
67_G 71_G 1.276 0.66
113_D 186_W 1.271 0.66
163_L 173_V 1.271 0.66
79_G 83_G 1.265 0.65
108_T 135_T 1.259 0.65
194_L 198_G 1.256 0.64
48_Q 51_A 1.255 0.64
49_M 52_H 1.239 0.63
45_A 49_M 1.235 0.63
182_S 201_V 1.228 0.62
117_A 216_W 1.225 0.62
142_A 165_V 1.213 0.60
23_V 27_E 1.197 0.59
8_K 11_T 1.197 0.59
27_E 33_I 1.194 0.59
108_T 207_D 1.191 0.58
28_P 31_T 1.187 0.58
19_Q 22_F 1.182 0.57
24_P 28_P 1.174 0.57
98_M 162_Q 1.169 0.56
41_E 50_Q 1.166 0.56
75_G 79_G 1.155 0.55
82_Q 85_A 1.139 0.53
165_V 173_V 1.137 0.53
123_M 166_H 1.136 0.53
122_Q 194_L 1.134 0.53
60_I 64_R 1.126 0.52
163_L 219_L 1.117 0.51
150_L 154_E 1.106 0.50
30_E 33_I 1.101 0.50
127_A 164_R 1.097 0.49
159_G 163_L 1.093 0.49
108_T 154_E 1.092 0.49
32_I 37_E 1.092 0.49
20_A 25_I 1.091 0.49
166_H 212_V 1.088 0.48
69_K 73_Q 1.084 0.48
105_F 154_E 1.084 0.48
61_A 87_A 1.082 0.48
93_P 165_V 1.077 0.47
195_H 213_A 1.077 0.47
65_Q 81_E 1.069 0.46
48_Q 55_G 1.066 0.46
199_C 214_T 1.066 0.46
190_G 212_V 1.066 0.46
83_G 91_Q 1.065 0.46
186_W 199_C 1.061 0.46
45_A 54_Q 1.06 0.45
86_E 90_Q 1.06 0.45
125_L 144_I 1.059 0.45
117_A 206_G 1.058 0.45
31_T 34_E 1.056 0.45
98_M 105_F 1.056 0.45
109_L 144_I 1.055 0.45
125_L 216_W 1.054 0.45
40_L 45_A 1.054 0.45
19_Q 23_V 1.053 0.45
40_L 55_G 1.048 0.44
115_V 202_S 1.047 0.44
65_Q 69_K 1.046 0.44
8_K 12_P 1.043 0.44
52_H 56_Y 1.039 0.43
131_V 151_L 1.037 0.43
73_Q 80_L 1.035 0.43
138_V 147_I 1.033 0.43
21_E 25_I 1.029 0.42
207_D 216_W 1.029 0.42
94_I 216_W 1.024 0.42
96_A 100_Q 1.022 0.42
168_D 196_P 1.022 0.42
64_R 130_Q 1.02 0.42
178_G 185_G 1.013 0.41
56_Y 60_I 1.012 0.41
49_M 53_E 1.011 0.41
130_Q 151_L 1.008 0.40
161_P 206_G 1.006 0.40
25_I 30_E 1.004 0.40
23_V 28_P 1.004 0.40
20_A 26_V 1.002 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2dm9A20.815899.60.745Contact Map0.257
3v6iA20.780799.30.785Contact Map0.231
4efaE10.881698.40.848Contact Map0.287
3lg8A20.403597.30.882Contact Map0.026
2lc0A10.460581.60.93Contact Map0.186
2wssS20.758827.40.951Contact Map0.032
1jy2N20.219323.40.953Contact Map0.126
3tu8A10.39048.50.961Contact Map0.054
1gtmA30.42547.50.962Contact Map0.02
3ehhA20.57026.90.963Contact Map0.098
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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