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OPENSEQ.org
EPTA - Phosphoethanolamine transferase EptA
UniProt: P30845 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11613
Length: 547 (538)
Sequences: 663
Seq/Len: 1.23
EPTA
Paralog alert: 0.58 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: EPTA EPTB EPTC YBIP YHBX YJGX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
241_I 432_V 4.576 1.00
520_T 539_L 4.037 1.00
384_S 424_T 4.006 1.00
254_N 271_Y 3.818 1.00
252_S 261_N 3.665 1.00
309_V 521_L 3.582 1.00
329_C 333_C 3.363 1.00
365_E 438_L 2.822 1.00
399_K 426_V 2.732 1.00
435_A 450_L 2.708 1.00
453_L 514_Q 2.671 1.00
394_P 427_Y 2.519 1.00
437_N 440_K 2.495 1.00
246_S 425_L 2.372 0.99
519_S 536_D 2.335 0.99
104_M 107_N 2.258 0.99
532_Y 537_D 2.205 0.99
263_R 430_Y 2.188 0.99
502_C 542_C 2.15 0.98
523_G 537_D 2.108 0.98
398_R 403_T 2.108 0.98
275_T 512_Y 2.09 0.98
246_S 428_V 2.044 0.97
313_I 525_T 2.002 0.97
278_C 288_C 1.951 0.96
132_G 136_A 1.944 0.96
238_T 376_V 1.886 0.95
249_E 478_S 1.817 0.94
218_R 221_E 1.799 0.94
320_V 336_V 1.782 0.93
246_S 384_S 1.777 0.93
358_E 427_Y 1.767 0.93
397_F 430_Y 1.761 0.93
246_S 251_F 1.735 0.92
523_G 532_Y 1.723 0.92
220_G 223_A 1.71 0.91
522_L 529_T 1.709 0.91
267_D 433_D 1.683 0.90
251_F 381_T 1.681 0.90
492_Y 520_T 1.67 0.90
431_I 435_A 1.665 0.90
350_C 355_C 1.659 0.89
246_S 454_S 1.617 0.88
238_T 449_S 1.614 0.88
240_L 376_V 1.591 0.87
237_L 446_F 1.581 0.86
23_Y 28_L 1.579 0.86
21_A 28_L 1.574 0.86
63_N 164_S 1.539 0.84
252_S 259_E 1.531 0.84
259_E 426_V 1.529 0.84
263_R 433_D 1.52 0.83
403_T 420_T 1.515 0.83
130_F 137_L 1.484 0.81
285_S 467_L 1.474 0.80
252_S 265_A 1.474 0.80
453_L 517_L 1.47 0.80
361_F 365_E 1.469 0.80
250_N 478_S 1.461 0.80
311_D 335_R 1.449 0.79
32_F 36_V 1.448 0.79
240_L 453_L 1.44 0.78
69_S 78_L 1.431 0.78
88_A 128_L 1.421 0.77
276_A 480_K 1.416 0.76
298_Y 425_L 1.413 0.76
175_F 179_Y 1.413 0.76
248_A 481_Q 1.4 0.75
234_R 447_T 1.395 0.75
356_Y 394_P 1.394 0.75
256_Y 422_D 1.392 0.75
404_C 412_C 1.391 0.75
431_I 538_I 1.39 0.75
289_M 453_L 1.39 0.75
398_R 401_T 1.379 0.74
458_E 479_Q 1.375 0.73
250_N 422_D 1.374 0.73
394_P 431_I 1.373 0.73
405_D 420_T 1.361 0.72
53_S 179_Y 1.36 0.72
80_C 140_C 1.356 0.72
465_I 470_L 1.352 0.72
459_S 479_Q 1.342 0.71
389_Y 458_E 1.338 0.71
316_A 525_T 1.334 0.70
289_M 517_L 1.332 0.70
216_L 307_E 1.33 0.70
247_R 439_L 1.319 0.69
449_S 492_Y 1.318 0.69
512_Y 538_I 1.315 0.69
422_D 487_W 1.311 0.68
259_E 265_A 1.307 0.68
413_T 416_Q 1.304 0.68
197_N 329_C 1.301 0.67
292_D 306_Q 1.295 0.67
365_E 369_N 1.294 0.67
240_L 378_V 1.293 0.67
313_I 521_L 1.293 0.67
258_R 422_D 1.291 0.67
250_N 418_V 1.283 0.66
486_L 520_T 1.277 0.65
365_E 442_H 1.276 0.65
361_F 438_L 1.265 0.64
237_L 368_I 1.262 0.64
83_I 139_A 1.261 0.64
222_D 529_T 1.252 0.63
216_L 335_R 1.252 0.63
118_A 388_T 1.252 0.63
313_I 322_W 1.249 0.63
60_S 167_L 1.243 0.62
80_C 139_A 1.24 0.62
247_R 467_L 1.229 0.61
248_A 271_Y 1.229 0.61
477_D 480_K 1.222 0.60
358_E 394_P 1.219 0.60
260_T 422_D 1.212 0.59
280_T 322_W 1.21 0.59
25_S 58_A 1.202 0.58
93_I 100_I 1.193 0.58
258_R 419_N 1.182 0.57
92_F 119_L 1.174 0.56
395_P 398_R 1.168 0.55
240_L 517_L 1.164 0.55
245_T 285_S 1.161 0.54
245_T 467_L 1.16 0.54
459_S 476_P 1.159 0.54
197_N 333_C 1.159 0.54
471_P 479_Q 1.154 0.54
80_C 136_A 1.151 0.53
486_L 539_L 1.148 0.53
24_I 66_L 1.147 0.53
239_I 379_L 1.146 0.53
397_F 427_Y 1.142 0.53
238_T 521_L 1.141 0.53
388_T 420_T 1.141 0.53
20_A 23_Y 1.137 0.52
246_S 261_N 1.127 0.51
311_D 515_D 1.126 0.51
239_I 435_A 1.126 0.51
468_H 522_L 1.121 0.51
98_I 470_L 1.121 0.51
476_P 479_Q 1.115 0.50
310_L 336_V 1.113 0.50
364_L 368_I 1.113 0.50
247_R 285_S 1.113 0.50
294_P 536_D 1.11 0.49
308_G 334_D 1.11 0.49
105_I 177_K 1.106 0.49
247_R 402_P 1.105 0.49
247_R 518_F 1.105 0.49
17_L 39_A 1.103 0.49
222_D 315_R 1.101 0.49
323_N 339_Q 1.1 0.49
112_T 140_C 1.1 0.49
253_L 269_V 1.099 0.48
393_Y 424_T 1.096 0.48
238_T 318_I 1.095 0.48
439_L 450_L 1.095 0.48
92_F 100_I 1.094 0.48
333_C 338_H 1.09 0.48
251_F 261_N 1.088 0.47
46_H 49_L 1.086 0.47
63_N 160_N 1.085 0.47
247_R 479_Q 1.082 0.47
110_D 327_G 1.082 0.47
328_G 469_G 1.082 0.47
33_F 36_V 1.078 0.46
50_V 179_Y 1.073 0.46
295_R 331_G 1.072 0.46
253_L 261_N 1.071 0.46
335_R 481_Q 1.069 0.45
422_D 458_E 1.069 0.45
314_Q 337_P 1.069 0.45
119_L 381_T 1.065 0.45
379_L 435_A 1.065 0.45
287_P 291_S 1.062 0.45
394_P 397_F 1.062 0.45
251_F 424_T 1.061 0.45
267_D 437_N 1.06 0.45
276_A 477_D 1.059 0.45
220_G 529_T 1.058 0.44
376_V 521_L 1.056 0.44
427_Y 430_Y 1.055 0.44
364_L 379_L 1.055 0.44
393_Y 398_R 1.054 0.44
288_C 404_C 1.054 0.44
267_D 440_K 1.05 0.44
459_S 475_A 1.049 0.44
393_Y 403_T 1.047 0.43
247_R 412_C 1.046 0.43
279_G 287_P 1.046 0.43
288_C 475_A 1.046 0.43
251_F 264_L 1.044 0.43
329_C 338_H 1.044 0.43
92_F 307_E 1.043 0.43
133_V 166_L 1.04 0.43
416_Q 420_T 1.038 0.42
286_V 481_Q 1.036 0.42
21_A 25_S 1.033 0.42
100_I 119_L 1.032 0.42
44_S 47_N 1.031 0.42
92_F 216_L 1.031 0.42
279_G 290_F 1.03 0.42
394_P 430_Y 1.029 0.42
153_S 157_R 1.028 0.42
288_C 476_P 1.023 0.41
56_V 170_L 1.023 0.41
500_Q 504_Q 1.022 0.41
88_A 120_M 1.021 0.41
468_H 479_Q 1.021 0.41
197_N 264_L 1.02 0.41
11_L 19_L 1.019 0.41
265_A 426_V 1.018 0.41
118_A 382_I 1.018 0.41
292_D 518_F 1.016 0.40
22_F 59_F 1.015 0.40
404_C 459_S 1.015 0.40
48_V 56_V 1.015 0.40
92_F 124_M 1.013 0.40
221_E 315_R 1.013 0.40
263_R 381_T 1.012 0.40
486_L 526_G 1.012 0.40
419_N 471_P 1.01 0.40
190_V 200_V 1.007 0.40
127_T 131_S 1.006 0.39
241_I 450_L 1.006 0.39
432_V 450_L 1.005 0.39
49_L 52_L 1.004 0.39
278_C 459_S 1.004 0.39
12_N 15_A 1.002 0.39
307_E 315_R 1.002 0.39
76_R 80_C 1.002 0.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4kavA10.60691000.687Contact Map0.695
3b5qA20.57221000.81Contact Map0.521
2qzuA10.58871000.814Contact Map0.489
2vqrA10.60511000.817Contact Map0.557
2w8dA20.57041000.822Contact Map0.501
3ed4A40.59051000.824Contact Map0.523
2w5qA10.57591000.826Contact Map0.526
3lxqA20.63991000.827Contact Map0.557
1aukA10.51371000.831Contact Map0.508
4fdiA20.51921000.835Contact Map0.568
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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