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OPENSEQ.org

MOAD - Molybdopterin synthase sulfur carrier subunit
UniProt: P30748 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11597
Length: 81 (81)
Sequences: 1155
Seq/Len: 14.26

MOAD
Paralog alert: 0.10 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
56_N 70_D 4.46 1.00
6_F 19_T 3.629 1.00
57_Q 71_E 2.644 1.00
3_K 18_A 2.629 1.00
55_V 64_H 2.155 1.00
7_F 73_A 2.114 1.00
27_T 30_A 1.987 1.00
31_L 66_L 1.953 1.00
75_F 79_T 1.881 1.00
39_S 42_W 1.755 1.00
60_V 64_H 1.704 1.00
31_L 72_V 1.692 1.00
9_Q 13_L 1.692 1.00
25_F 34_H 1.675 1.00
28_V 53_A 1.663 1.00
2_I 69_G 1.662 1.00
32_R 74_F 1.655 1.00
75_F 78_V 1.614 1.00
22_A 25_F 1.566 1.00
54_A 73_A 1.481 1.00
54_A 59_L 1.474 1.00
67_T 70_D 1.406 0.99
26_P 30_A 1.365 0.99
6_F 16_T 1.242 0.98
54_A 57_Q 1.234 0.98
6_F 14_V 1.201 0.98
11_R 17_D 1.185 0.98
6_F 74_F 1.181 0.98
32_R 62_F 1.178 0.98
59_L 75_F 1.174 0.98
16_T 19_T 1.153 0.97
30_A 33_Q 1.006 0.93
71_E 79_T 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vjkA1199.80.121Contact Map0.753
1fm0D1199.80.133Contact Map0.853
2k9xA10.987799.80.143Contact Map0.47
1wgkA1199.80.143Contact Map0.513
3po0A1199.70.145Contact Map0.714
4hroA2199.70.151Contact Map0.725
2qjlA1199.70.152Contact Map0.603
2q5wD10.938399.70.186Contact Map0.772
2m19A1199.70.186Contact Map0.625
2g1eA10.987799.70.193Contact Map0.61

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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